Evidence for age-dependent impairment of antiviral 2′,5′-oligoadenylate synthetase/ribonuclease l-system in tissues of rat

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The Fluorometric Measurement of Deoxyribonucleic Acid in Animal Tissues with Special Reference to the Central Nervous System

1958 • 1,786 citations

Nuclei from Rat Liver: Isolation Method That Combines Purity with High Yield

1966 • 1,687 citations

Biochemistry of Interferons and Their Actions

1982 • 868 citations

Interferon action—sequence specificity of the ppp(A2′p)nA-dependent ribonuclease

1981 • 321 citations

RECOMBINANT HUMAN INTERFERON ALFA-A SUPPRESSES HTLV-III REPLICATION IN VITRO

1985 • 306 citations

Constitutive expression of (2′–5′) oligo A synthetase confers resistance to picornavirus infection

1987 • 277 citations

Four different forms of interferon-induced 2',5'-oligo(A) synthetase identified by immunoblotting in human cells.

1987 • 229 citations

Pre-mRNA splicing and the nuclear matrix.

1987 • 220 citations

Cordycepin analogs of 2',5'-oligoadenylate inhibit human immunodeficiency virus infection via inhibition of reverse transcriptase

1991 • 137 citations

Activation of the ppp(A2'p)nA system in interferon-treated, Herpes simplex virus-infected cells and evidence for novel inhibitors of the ppp(A2'p)nA-dependent RNase

1984 • 127 citations

Anti‐mitogenic Function of Interferon‐Induced (2′‐5′)Oligo(adenylate) and Growth‐Related Variations in Enzymes that Synthesize and Degrade This Oligonucleotide

1981 • 122 citations

Interferon action: Two (2′-5′) (A)n synthetases specified by distinct mRNAs in Ehrlich ascites tumor cells treated with interferon

1983 • 118 citations

Purification and analysis of murine 2-5A-dependent RNase.

1988 • 83 citations

Modulation of Nuclear Matrix-associated 2′,5′-Oligoadenylate Metabolism and Ribonuclease L Activity in H9 Cells by Human Immunodeficiency Virus

1989 • 82 citations

Regulation of ppp(A2'p)nA-dependent RNase levels during interferon treatment and cell differentiation

1985 • 79 citations

Induction of ppp(A2'p)nA-dependent RNase in murine JLS-V9R cells during growth inhibition.

1983 • 79 citations

Synthesis, Characterization and Properties of ppp(A2′p)nApCp and Related High-Specific-Activity 32P-Labelled Derivatives of ppp(A2′p)nA

2005 • 79 citations

Affinity Labelling and Characterization of the ppp(A2′p)_nA‐Dependent Endoribonuclease from Different Mammalian Sources

1982 • 78 citations

Expression of the 2-5A system druing the cell cycle

1985 • 77 citations

Continuous Production of Interferon in Normal Mice: Effect of Anti-interferon Globulin, Sex, Age, Strain and Environment on the Levels of 2-5A Synthetase and p67K Kinase

1985 • 72 citations

Purification and characterization of a poly(A)-specific exoribonuclease from calf thymus.

1980 • 71 citations

Binding of Tat Protein to TAR Region of Human Immunodeficiency Virus Type 1 Blocks TAR-Mediated Activation of (2′-5′)Oligoadenylate Synthetase

1990 • 69 citations

Double-stranded RNA causes synthesis of 2‘,5‘-oligo(A) and degradation of messenger RNA in interferon-treated cells.

1981 • 66 citations

Presence of 2',5'-oligo(A) and of enzymes that synthesize, bind, and degrade 2',5'-oligo(A) in HeLa cell nuclei.

1982 • 64 citations

2′5′ Obgoadenylate synthetase, an interferon induced enzyme: direct assay methods for the products, 2′5′ ohgoadenylates and 2′5′ co-oligonucleotides

1980 • 63 citations

Functional characterization of Tat protein from human immunodeficiency virus. Evidence that Tat links viral RNAs to nuclear matrix.

1990 • 61 citations

(2'-5')Oligoadenylate in rat liver: modulation after partial hepatectomy.

1983 • 59 citations

Studies on protein kinases involved in regulation of nucleocytoplasmic mRNA transport

1988 • 56 citations

Interferon action. Covalent linkage of (2'-5')pppApApA(32P)pCp to (2'-5')(A)n-dependent ribonucleases in cell extracts by ultraviolet irradiation.

1982 • 53 citations

Purification and characterization of a 2′-phosphodiesterase from bovine spleen.

1987 • 50 citations

(2′-5′)Oligoadenylate and intracellular immunity against retrovirus infection

1992 • 49 citations

Heterogeneous nuclear RNA promotes synthesis of (2',5')oligoadenylate and is cleaved by the (2',5')oligoadenylate-activated endoribonuclease.

1982 • 48 citations

Loss of (2'-5')oligoadenylate synthetase activity by production of antisense RNA results in lack of protection by interferon from viral infections.

1987 • 45 citations

Immunological evidence for the in vivo occurrence of (2'-5')adenylyladenosine oligonucleotides in eukaryotes and prokaryotes.

1984 • 37 citations

Protection of HeLa‐T4 ⁺ cells against human immunodeficiency virus (HIV) infection after stable transfection with HIV LTR‐2‘,5‘‐oligoadenylate synthetase hybrid gene ¹

1990 • 36 citations

Adenoviral Heterogeneous Nuclear RNA Is Associated with Host Cell Proteins

1981 • 32 citations

Regulation of endogenous murine leukemia virus-related nuclear and cytoplasmic RNA complexity in C57BL/6J mice of increasing age.

1980 • 29 citations

Alteration of Nuclear (2´-5´) Oligoriboadenylate Synthetase and Nuclease Activities Preceding Replication of Human Immunodeficiency Virus in H9 Cells

1988 • 28 citations

Selective inhibition of formation of suppressor glutamine tRNA in moloney murine leukemia virus-infected NIH-3T3 cells by Avarol

1988 • 25 citations

Association of Tat protein and viral mRNA with nuclear matrix from HIV-1-infected H9 cells

1989 • 21 citations

Occurrence of 2-5A and RNA degradation in the chick oviduct during rapid estrogen withdrawal

1988 • 19 citations

Age-Dependent Changes Are Observed in the Levels of an Enzyme Mediator of Interferon Action: A (2'-5')An-Dependent Endoribonuclease

1988 • 10 citations

Interferons: direct effects upon viral replication

1985 • 8 citations

Age-related differences in the induction of 2–5A synthetase and 2–5A dependent binding protein activities by interferon in guinea pig peritoneal macrophages

1986 • 5 citations

Double stranded RNA and the nuclear matrix--implications for the 2-5A system.

1985 • 3 citations

Deleted Work

1955 • 0 citations