Syk-dependent and -independent Signaling Cascades in B Cells Elicited by Osmotic and Oxidative Stress

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Signal transduction via the MAP kinases: proceed at your own RSK.

1993 • 1,262 citations

Activation of Mitogen-activated Protein Kinase by H2O2

1996 • 1,202 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

1992 • 1,037 citations

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1992 • 980 citations

Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

1995 • 935 citations

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

1991 • 800 citations

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1995 • 726 citations

Cytokine Signaling Through Nonreceptor Protein Tyrosine Kinases

1995 • 713 citations

Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways.

1994 • 664 citations

Syk tyrosine kinase required for mouse viability and B-cell development

1995 • 632 citations

An Osmosensing Signal Transduction Pathway in Mammalian Cells

1994 • 584 citations

Increased ratio of targeted to random integration after transfection of chicken B cell lines

1991 • 534 citations

The Role of Protein Tyrosine Kinases and Protein Tyrosine Phosphatases in T Cell Antigen Receptor Signal Transduction

1994 • 519 citations

Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents

1995 • 486 citations

Involvement of growth factor receptors in the mammalian UVC response

1994 • 456 citations

Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis

1991 • 449 citations

Extracellular signals and reversible protein phosphorylation: What to Mek of it all

1993 • 426 citations

Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling.

1994 • 299 citations

Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor.

1992 • 298 citations

Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase

1994 • 294 citations

Tyrosine kinases in activation of the MAP kinase cascade by G-protein-coupled receptors

1996 • 275 citations

Reactive oxygen intermediates activate NF-kappa B in a tyrosine kinase- dependent mechanism and in combination with vanadate activate the p56lck and p59fyn tyrosine kinases in human lymphocytes

1993 • 260 citations

Activation of the mitogen-activated protein kinase signaling pathway in neutrophils. Role of oxidants.

1994 • 212 citations

Cellular Stresses Differentially Activate c-Jun N-terminal Protein Kinases and Extracellular Signal-regulated Protein Kinases in Cultured Ventricular Myocytes

1995 • 212 citations

Transforming G Protein-coupled Receptors Potently Activate JNK (SAPK)

1995 • 211 citations

Cell Cycle—Regulated Binding of c-Abl Tyrosine Kinase to DNA

1992 • 202 citations

SOS Phosphorylation and Disassociation of the Grb2-SOS Complex by the ERK and JNK Signaling Pathways

1996 • 180 citations

Activation of the Lck tyrosine protein kinase by hydrogen peroxide requires the phosphorylation of Tyr-394.

1995 • 179 citations

p72syk tyrosine kinase is activated by oxidizing conditions that induce lymphocyte tyrosine phosphorylation and Ca2+ signals

1993 • 167 citations

Activation of Protein Kinase Cascades by Osmotic Shock

1995 • 154 citations

ZAP-70 tyrosine kinase, CD45, and T cell receptor involvement in UV- and H2O2-induced T cell signal transduction.

1994 • 150 citations

Endogenous Reactive Oxygen Intermediates Activate Tyrosine Kinases in Human Neutrophils

1996 • 142 citations

A Requirement for Syk in the Activation of the Microtubule-associated Protein Kinase/Phospholipase A2 Pathway by FcεR1 Is Not Shared by a G Protein-coupled Receptor

1995 • 142 citations

Protein-tyrosine kinase p72syk is activated by thrombin and is negatively regulated through Ca2+ mobilization in platelets.

1993 • 127 citations

c-Abl Activation Regulates Induction of the SEK1/Stress-activated Protein Kinase Pathway in the Cellular Response to 1-β-D-Arabinofuranosylcytosine

1995 • 125 citations

Association with B‐cell‐antigen receptor with protein‐tyrosine kinase p72^syk and activation by engagement of membrane IgM

1993 • 110 citations

Activation of Src-like p56/p53lyn tyrosine kinase by ionizing radiation.

1994 • 95 citations

Cooperation of Tyrosine Kinases P72^syk and P53/56^lyn Regulates Calcium Mobilization in Chicken B Cell Oxidant Stress Signaling

1996 • 59 citations

Activation and tyrosine phosphorylation of p72syk as well as calcium mobilization after hydrogen peroxide stimulation in peripheral blood lymphocytes

1995 • 49 citations

Effects of epidermal growth factor on the tyrosine phosphorylation of mitogen-activated protein kinases in monolayer cultures of porcine granulosa cells.

1995 • 43 citations

p56/p53lyn tyrosine kinase activation in mammalian cells treated with mitomycin C.

1994 • 33 citations

Hypotonically Induced Calcium Release from Intracellular Calcium Stores

1996 • 31 citations