Nicotine enhances the learning and memory of aged rats

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

Psychopharmacology: The third generation of progress

1988 • 3,403 citations

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

1983 • 3,028 citations

Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.

1978 • 2,036 citations

Psychopharmacology: The Third Generation of Progress.

1988 • 1,973 citations

Spatial memory and hippocampal function

1979 • 940 citations

Nicotinic systems and cognitive function

1992 • 519 citations

The Effects of Nicotine on Attention, Information Processing, and Short-Term Memory in Patients with Dementia of the Alzheimer Type

1989 • 491 citations

Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in alzheimer's disease

1992 • 478 citations

Neuronal loss in different parts of the nucleus basalis is related to neuritic plaque formation in cortical target areas in alzheimer's disease

1985 • 407 citations

An evaluation of spatial information processing in aged rats.

1987 • 353 citations

Differential Alteration of Various Cholinergic Markers in Cortical and Subcortical Regions of Human Brain in Alzheimer's Disease

1988 • 334 citations

The effects of aging on hippocampal and cortical projections of the forebrain cholinergic system

1987 • 318 citations

Progressive decline in spatial learning and integrity of forebrain cholinergic neurons in rats during aging

1992 • 294 citations

In Vivo Regulation of [³H]Acetylcholine Recognition Sites in Brain by Nicotinic Cholinergic Drugs

1985 • 283 citations

Time course study of the effects of chronic nicotine infusion on drug response and brain receptors.

1985 • 271 citations

Spatial learning deficits in old rats: A model for memory decline in the aged

1988 • 255 citations

Animal Models of Declining Memory in the Aged: Short-term and Spatial Memory in the Aged Rat

1980 • 227 citations

Age and neurochemical correlates of radial maze performance in rats

1981 • 217 citations

Aging Decreases Oxidative Metabolism and the Release and Synthesis of Acetylcholine

1981 • 215 citations

Chapter 15 Presynaptic modulation of transmitter release by nicotinic receptors

1989 • 200 citations

A postmortem study of brain nicotinic receptors in Parkinson's and Alzheimer's disease

1991 • 191 citations

Nicotine as a cognitive enhancer

1992 • 175 citations

Cholinergic modulation of memory in rats

1985 • 166 citations

Beneficial effects of nicotine administered prior to a delayed matching-to-sample task in young and aged monkeys

1991 • 163 citations

Nicotinic cholinoceptive neurons of the frontal cortex are reduced in Alzheimer's disease

1991 • 149 citations

Effects of nicotine on spatial memory deficits in rats with septal lesions

1992 • 142 citations

Complex maze learning in rodents as a model of age-related memory impairment

1988 • 139 citations

Chronic nicotine and withdrawal effects on radial-arm maze performance in rats

1990 • 133 citations

Rapid forgetting in aged rats

1982 • 130 citations

Chronic nicotine reverses working memory deficits caused by lesions of the fimbria or medial basalocortical projection

1993 • 112 citations

Analysis of Age‐Related Impairments in Learning and Memory in Rodent Models

1985 • 103 citations

Learning by Mature-young and Aged Wistar Albino Rats As a Function of Test Complexity

1972 • 102 citations

Cholinergic receptors in human brain: Effects of aging and alzheimer disease

1990 • 100 citations

Chronic nicotinic stimulation and blockade effects on working memory

1993 • 95 citations

Nicotinic and muscarinic interactions and choice accuracy in the radial-arm maze

1991 • 92 citations

Radial-arm maze deficits produced by colchicine administered into the area of the nucleus basalis are ameliorated by cholinergic agents

1988 • 81 citations

Aging Decreases the Sensitivity of Rat Cortical Synaptosomes to Calcium Ionophore‐Induced Acetylcholine Release

1986 • 74 citations

Age dependent changes in retention in rats I

1982 • 74 citations

Novel Approaches to the Treatment of Alzheimer’s Disease

1989 • 60 citations

Effect of Amphetamine, Nicotine and Hexamethonium on Performance of a Conditioned Response During Acquisition and Retention Trials

1970 • 57 citations

Active and passive avoidance in rats as a function of age

1977 • 56 citations

The biology of nicotine, current research issues

1993 • 49 citations

Studies on the mechanism of avoidance facilitation by nicotine

1971 • 44 citations

The effect of pre- and post-trial application of nicotine on the 12 problems of the Hebb-Williams-test in the rat

1970 • 43 citations

Sertraline attenuates hyperphagia in rats following nicotine withdrawal

1993 • 33 citations

The Biology of Nicotine: Current Research Issues

1992 • 31 citations

Basal forebrain cholinergic neurons in aged rat brain are more susceptible to ibotenate-induced degeneration than neurons in young adult brain

1992 • 23 citations

Nucleus basalis lesions in neonate rats induce a selective cortical cholinergic hypofunction and cognitive deficits during adulthood

1992 • 21 citations

Acquisition and retention of different learning tasks in old rats

1982 • 15 citations