Behavioral effects and anticonvulsant efficacies of low-affinity, uncompetitive NMDA antagonists in mice

Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans

1994 • 3,182 citations

Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

1992 • 626 citations

Clinical Experience With Excitatory Amino Acid Antagonist Drugs

1995 • 499 citations

[³H]MK‐801 Labels a Site on the N‐Methyl‐D‐Aspartate Receptor Channel Complex in Rat Brain Membranes

1988 • 453 citations

The behavioural effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor

1989 • 434 citations

Glutamate in CNS disorders as a target for drug development: an update

1998 • 423 citations

The behavioral pharmacology of NMDA receptor antagonists

1990 • 331 citations

Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines

1993 • 318 citations

Aminoadamantanes as NMDA receptor antagonists and antiparkinsonian agents — preclinical studies

1997 • 317 citations

Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo

1995 • 300 citations

Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties.

1994 • 283 citations

Memantine displaces [3H]MK-801 at therapeutic concentrations in postmortem human frontal cortex

1989 • 251 citations

Effects and aftereffects of ibogaine on morphine self-administration in rats

1991 • 194 citations

Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum

1994 • 183 citations

Cerebrospinal fluid and serum concentrations of the N-methyl-d-aspartate (NMDA) receptor antagonist memantine in man

1995 • 155 citations

Efficacy of memantine, an NMDA receptor antagonist, in the treatment of Parkinson's disease

1992 • 137 citations

Regional Variations in the Pharmacology of NMDA Receptor Channel Blockers: Implications for Therapeutic Potential

1995 • 137 citations

Effects of ibogaine on acute signs of morphine withdrawal in rats: Independence from tremor

1992 • 119 citations

Medication development of ibogaine as a pharmacotherapy for drug dependence.

1998 • 117 citations

Different binding affinities of NMDA receptor channel blockers in various brain regions—Indication of NMDA receptor heterogeneity

1995 • 115 citations

Therapeutic brain concentration of the NMDA receptor antagonist amantadine

1995 • 109 citations

The NMDA antagonist memantine blocks the expression and maintenance of morphine dependence

1996 • 105 citations

Inhibition of reinforcing effects of morphine and motivational aspects of naloxone-precipitated opioid withdrawal by N-methyl-D-aspartate receptor antagonist, memantine.

1997 • 102 citations

N-Methyl-d-aspartic acid-induced lethality in mice: selective antagonism by phencylidine-like drugs

1988 • 97 citations

NMDA antagonist properties of the putative antiaddictive drug, ibogaine.

1995 • 93 citations

Many agents that antagonize the NMDA receptor-channel complex in vivo also cause disturbances of motor coordination.

1994 • 92 citations

The putative anti-addictive drug ibogaine is a competitive inhibitor of [3H]MK-801 binding to the NMDA receptor complex

1994 • 92 citations

Mechanisms of antiaddictive actions of ibogaine.

1998 • 88 citations

Comparison of the effects of the uncompetitive N-methyl-D-aspartate antagonist (+-)-5-aminocarbonyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine (ADCI) with its structural analogs dizocilpine (MK-801) and carbamazepine on ethanol withdrawal seizures.

1992 • 85 citations

Sensitive and rapid behavioral differentiation ofN-methyl-d-aspartate receptor antagonists

1994 • 83 citations

Anticonvulsant activity of the low-affinity uncompetitive N-methyl-D- aspartate antagonist (+-)-5-aminocarbonyl-10,11-dihydro-5H- dibenzo[a,d]cyclohepten-5,10-imine (ADCI): comparison with the structural analogs dizocilpine (MK-801) and carbamazepine.

1991 • 59 citations

Dizocilpine-like Discriminative Stimulus Effects of Low-affinity Uncompetitive NMDA Antagonists

1996 • 59 citations

Ibogaine block of the NMDA receptor: In vitro and in vivo studies

1996 • 53 citations

Amantadine and the glutamate hypothesis of schizophrenia Experiences in the treatment of neuroleptic malignant syndrome

1993 • 44 citations

Anticonvulsant efficacy of N-methyl-D-aspartate antagonists against convulsions induced by cocaine.

1999 • 40 citations

Evaluation of the reinforcing and discriminative stimulus properties of the low-affinity N-methyl-D-aspartate channel blocker memantine.

1998 • 36 citations

Synthesis and structure-activity relationship of C5-substituted analogs of (.+-.)-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5, 10-imine [(.+-.)-desmethyl-MK801]: ligands for the NMDA receptor-coupled phencyclidine binding site

1990 • 35 citations

Receptor Mediation of the Discriminative Stimulus Properties of Phencyclidine and Sigma-Opioid Agonists

1988 • 34 citations

Memantine has phencyclidine-like but not cocaine-like discriminative stimulus effects in rats

1992 • 28 citations

The discriminative stimulus effects of MK-801: Generalization to other N-methyl-D-aspartate receptor antagonists

1989 • 23 citations

Effect of ibogaine on the various sites of the NMDA receptor complex and sigma binding sites in rat brain.

1998 • 22 citations

Evaluation of ADCI against convulsant and locomotor stimulant effects of cocaine: Comparison with structural analogs dizocilpine and carbamazepine

1994 • 19 citations

The Effects of Sigma, PCP, and Opiate Receptor Ligands in Rats Trained With Ibogaine as a Discriminative Stimulus

1998 • 16 citations

Ibogaine attenuates morphine-induced conditioned place preference.

1995 • 15 citations

Ibogaine fails to interrupt the expression of a previously established one-trial morphine place preference

1996 • 12 citations

Failure of Ibogaine to Produce Phencyclidine-Like Discriminative Stimulus Effects in Rats and Monkeys

1998 • 11 citations

Neurochemical and neuroendocrine effects of ibogaine in rats: comparison to MK-801.

1998 • 10 citations