Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties.

Influenza virus M2 protein has ion channel activity

1992 • 1,205 citations

Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced

1988 • 972 citations

Federal Republic of Germany

1985 • 938 citations

NMDA Antagonist Neurotoxicity: Mechanism and Prevention

1991 • 837 citations

Antiviral Activity of 1-Adamantanamine (Amantadine)

1964 • 805 citations

Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia

1980 • 703 citations

Secretion of Neurotoxins by Mononuclear Phagocytes Infected with HIV-1

1990 • 628 citations

Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

1992 • 626 citations

Amantadine in the Treatment of Parkinson's Disease

1969 • 599 citations

Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists

1991 • 554 citations

Role for Excitatory Amino Acids in Methamphetamine-Induced Nigrostriatal Dopaminergic Toxicity

1989 • 495 citations

Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channels

1989 • 347 citations

Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor-gated ion channel: a human postmortem brain study

1991 • 303 citations

Patch clamp studies on the kinetics and selectivity of N-methyl-d-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan)

1993 • 278 citations

(3H]MK-801 binding sites in postmortem brain regions of schizophrenic patients

1989 • 250 citations

MK‐801 and ketamine induce heat shock protein HSP72 in injured neurons in posterior cingulate and retrosplenial cortex

1991 • 233 citations

NMDA receptors and in vivo dopamine release in the nucleus accumbens and caudatus

1990 • 221 citations

Catatonic Reactions to High-Potency Neuroleptic Drugs

1977 • 213 citations

Presynaptic dopaminergic modulation of cortical input to the striatum

1986 • 184 citations

gp120 of HIV-1 induces apoptosis in rat cortical cell cultures: prevention by memantine

1992 • 174 citations

Absorption, distribution and excretion of amantadine hydrochloride.

1965 • 164 citations

Neuroprotective effect of memantine demonstrated in vivo and in vitro

1990 • 157 citations

MK‐801 Prevents 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine‐Induced Parkinsonism in Primates

1992 • 155 citations

Efficacy and tolerability of memantine in patients with dementia syndrome. A double-blind, placebo controlled trial.

1991 • 124 citations

A Controlled Trial of Amantadine in Drug-Induced Extrapyramidal Disorders

1976 • 121 citations

Memantine in the treatment of mild to moderate dementia syndrome. A double-blind placebo-controlled study.

1992 • 121 citations

MK‐801 Fails to Protect Against the Dopaminergic Neuropathology Produced by Systemic 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine in Mice or Intranigral 1‐Methyl‐4‐Phenylpyridinium in Rats

1992 • 120 citations

Memantine is highly potent in protecting cortical cultures against excitotoxic cell death evoked by glutamate and N-methyl-D-aspartate

1991 • 106 citations

Pharmacological changes in dopaminergic systems induced by long-term administration of amantadine

1985 • 99 citations

Antipsychotic drugs block phencyclidine receptor-mediated neurotoxicity

1993 • 98 citations

The anti-parkinsonian drug amantadine inhibits the N-methyl-D-aspartic acid-evoked release of acetylcholine from rat neostriatum in a non-competitive way

1992 • 94 citations

Phencyclidine: an overview.

1978 • 93 citations

NMDA receptor-mediated glutamate toxicity of cultured cerebellar, cortical and mesencephalic neurons: neuroprotective properties of amantadine and memantine

1993 • 78 citations

Inhibitory effects of the antiparkinsonian drugs memantine and amantadine on N-methyl-D-aspartate-evoked acetylcholine release in the rabbit caudate nucleus in vitro.

1992 • 74 citations

[3H]MK-801 binding sites in post-mortem human frontal cortex

1989 • 61 citations

Possible abuse potential of the NMDA antagonist MK-801

1989 • 59 citations

Evaluation of amantadine as a releasing agent or uptake blocker for H3-dopamine in rat brain slices

1972 • 58 citations

Autoradiographic assessment of the effects of N-methyl-d-aspartate (NMDA) receptor antagonists in vivo

1991 • 56 citations

Amantadine kinetics in healthy young subjects after long‐term dosing

1979 • 56 citations

Memantine prevents quinolinic acid-induced hippocampal damage

1992 • 55 citations

The effect of amantadine on motor activity and catalepsy in rats

1972 • 53 citations

A rationale for NMDA receptor antagonist therapy of the neuroleptic malignant syndrome

1992 • 49 citations

Transport of amantadine and rimantadine through the blood-brain barrier.

1988 • 49 citations

Chronic administration of NMDA antagonists induces D2 receptor synthesis in rat striatum

1992 • 47 citations

Effects of memantine on the frog neuromuscular junction

1986 • 46 citations

Amantadine and the glutamate hypothesis of schizophrenia Experiences in the treatment of neuroleptic malignant syndrome

1993 • 44 citations

Discriminative stimulus properties of phencyclidine

1979 • 44 citations

Effect of amantadine on drug‐induced parkisonism: relationship between plasma levels and effect.

1976 • 44 citations

3-nitropropionic acid is an indirect excitotoxin to cultured cerebellar granule neurons

1993 • 44 citations

Anticataleptic potencies of glutamate-antagonists

1991 • 41 citations

Distribution and Metabolism of the Potential Anti-Parkinson Drng Memantine in the Human

1980 • 38 citations

Memantine stimulates inositol phosphates production in neurones and nullifies N- destruction of retinal neurones

1992 • 35 citations

Amantadine may stimulate dopamine and noradrenaline receptors

1974 • 35 citations

The clinically available NMDA receptor antagonist memantine is antinociceptive on rat spinal neurones

1993 • 35 citations

Fatal Overdose with Amantadine

1986 • 31 citations

Structure-activity relationships of amantadine. I. Interaction of the N-alkyl analogues with the ionic channels of the nicotinic acetylcholine receptor and electrically excitable membrane.

1982 • 30 citations

Distribution of memantine in brain, liver, and blood of the rat.

1982 • 30 citations

Animal models of intravenous phencyclinoid self-administration

1987 • 29 citations

Memantine has phencyclidine-like but not cocaine-like discriminative stimulus effects in rats

1992 • 28 citations

Antiparkinsonian drugs and in vitro excitotoxicity

1992 • 23 citations

In vitro studies on the possible effects of 1-aminoadamantanes on the serotonergic system in M. Parkinson

1979 • 22 citations

The effect of memantine on various neurobiological processes.

1982 • 20 citations

Amantadine: evaluation of reinforcing properties and effect on cocaine self-injection in baboons

1988 • 19 citations

Memantine inhibits serotonin-induced rise of cytosolic Ca2+ activity and of cyclic GMP level in a neuronal cell line

1989 • 19 citations

MK-801 and memantine protect cultured neurons from glutamate toxicity induced by glutamate carboxypeptidase-mediated cleavage of methotrexate

1993 • 18 citations

(NMDA)-mediated muscle relaxant action of memantine in rats

1992 • 17 citations

Amantadine and D-145, an amantadine derivative, do not effect dopamine sensitive adenylate cyclase from the caudate-putamen of the rat brain

1974 • 14 citations

In Reply: Phencyclidine, Dizocilpine, and Cerebrocortical Neurons

1990 • 9 citations

Modulation of glycine-activated membrane current by adamantane derivatives

1991 • 9 citations

Phencyclidin und das glutamaterge System

1986 • 9 citations

Partially protective effect of amantadine in the MPTP model of Parkinson's disease.

1992 • 7 citations

Effect of Amantadine on Prolactin Secretion, Pituitary DNA Synthesis and <sup>3</sup>H-Spiperone Binding in Male Estrogen-Treated Rats

1990 • 3 citations

Memantine: Suppression of High Frequency Action Potentials is caused by Prolongation of the Sodium Current Refractory Period

1991 • 2 citations

Protection by CPP from MPTP-induced neurodegeneration in marmosets

1992 • 1 citations