Different binding affinities of NMDA receptor channel blockers in various brain regions—Indication of NMDA receptor heterogeneity

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Cloned Glutamate Receptors

1994 • 3,989 citations

Molecular Diversity of Glutamate Receptors and Implications for Brain Function

1992 • 2,535 citations

Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes

1992 • 2,527 citations

Excitatory amino acid neurotoxicity and neurodegenerative disease

1990 • 1,781 citations

Molecular cloning and characterization of the rat NMDA receptor

1991 • 1,780 citations

Molecular diversity of the NMDA receptor channel

1992 • 1,354 citations

Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs

1992 • 805 citations

Cooperative Modulation of [³H]MK‐801 Binding to the N‐Methyl‐d‐Aspartate Receptor‐Ion Channel Complex by l‐Glutamate, Glycine, and Polyamines

1988 • 755 citations

Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

1992 • 626 citations

Zinc potentiates agonist-lnduced currents at certain splice variants of the NMDA receptor

1993 • 605 citations

Amantadine in the Treatment of Parkinson's Disease

1969 • 599 citations

Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing

1992 • 521 citations

[³H]MK‐801 Labels a Site on the N‐Methyl‐D‐Aspartate Receptor Channel Complex in Rat Brain Membranes

1988 • 453 citations

The novel anticonvulsant MK‐801 binds to the activated state of the N‐methyl‐<scp>d</scp>‐aspartate receptor in rat brain

1987 • 452 citations

Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channels

1989 • 347 citations

Splice variants of the N-methyl-D-aspartate receptor NR1 identify domains involved in regulation by polyamines and protein kinase C.

1993 • 347 citations

Distinct distributions of five N‐methyl‐<scp>D</scp>‐aspartate receptor channel subunit mRNAs in the forebrain

1993 • 316 citations

Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor-gated ion channel: a human postmortem brain study

1991 • 303 citations

Cloning and expression of the ε4 subunit of the NMDA receptor channel

1992 • 296 citations

Patch clamp studies on the kinetics and selectivity of N-methyl-d-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan)

1993 • 278 citations

Memantine displaces [3H]MK-801 at therapeutic concentrations in postmortem human frontal cortex

1989 • 251 citations

Calculating receptor number from binding experiments using same compound as radioligand and competitor

1989 • 250 citations

Glutamate antagonists have different effects on spontaneous locomotor activity in rats

1994 • 186 citations

Different sensitivities of NMDA receptor channel subtypes to non-competitive antagonists

1993 • 185 citations

Efficacy of memantine, an NMDA receptor antagonist, in the treatment of Parkinson's disease

1992 • 137 citations

Regional Variations in the Pharmacology of NMDA Receptor Channel Blockers: Implications for Therapeutic Potential

1995 • 137 citations

Amantadine in the treatment of Parkinson's disease

1969 • 117 citations

Regional distribution and properties of [3H]MK-801 binding sites determined by quantitative autoradiography in rat brain

1991 • 107 citations

Memantine is highly potent in protecting cortical cultures against excitotoxic cell death evoked by glutamate and N-methyl-D-aspartate

1991 • 106 citations

Wirkungen oraler Memantin-Gaben auf die Parkinson-Symptomatik: Ergebnisse einer placebo-kontrollierten Multicenter-Studie

2008 • 95 citations

Delayed administration of memantine prevents N‐methyl‐<scp>D</scp>‐aspartate receptor‐mediated neurotoxicity

1993 • 86 citations

Differential stimulation of [3H]MK-801 binding to subpopulations of NMDA receptors

1991 • 79 citations

NMDA receptor-mediated glutamate toxicity of cultured cerebellar, cortical and mesencephalic neurons: neuroprotective properties of amantadine and memantine

1993 • 78 citations

Regional Variations in [³H]MK801 Binding to Rat Brain N‐Methyl‐D‐Aspartate Receptors

1991 • 77 citations

Identification of a novel NMDA receptor in rat cerebellum

1991 • 70 citations

Identification of a Novel N‐Methyl‐D‐Aspartate Receptor Population in the Rat Medial Thalamus

1992 • 67 citations

Heterogeneity of the N-methyl-D-aspartate receptor ionophore complex in rat brain, as revealed by ligand binding techniques.

1991 • 66 citations

Memantine inhibits [3H]MK-801 binding to human hippocampal NMDA receptors

1994 • 16 citations

Inhibition of autoradiographic MK-801 binding by an endogenous factor

1994 • 8 citations