The NMDA antagonist memantine blocks the expression and maintenance of morphine dependence
Data up to Jan 2025
Total Citations Per Year
Abstract
References (55)
Goodman and Gilman's the Pharmacological Basis of Therapeutics
1986 • 6,964 citations
Magnesium gates glutamate-activated channels in mouse central neurones
1984 • 3,999 citations
[Drug addiction and drug abuse].
1969 • 1,466 citations
Requirement for Glycine in Activation of NMDA-Receptors Expressed in Xenopus Oocytes
1988 • 1,415 citations
Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801
1991 • 1,212 citations
Functional antagonists at the NMDA receptor complex exhibit antidepressant actions
1990 • 754 citations
Evidence from rats that morphine tolerance is a learned response.
1975 • 655 citations
Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity
1992 • 626 citations
Marked inhibition of mesolimbic dopamine release: a common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats
1992 • 525 citations
Excitatory amino acids and Alzheimer's disease
1989 • 485 citations
Electrophysiological studies of NMDA receptors
1987 • 483 citations
Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channels
1989 • 347 citations
Morphine Analgesic Tolerance: Its Situation Specificity Supports a Pavlovian Conditioning Model
1976 • 320 citations
Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor-gated ion channel: a human postmortem brain study
1991 • 303 citations
The NMDA Receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids
1994 • 279 citations
Opiate withdrawal-induced hyperactivity of locus coeruleus neurons is substantially mediated by augmented excitatory amino acid input
1991 • 269 citations
Sigma and phencyclidine-like compounds as molecular probes in biology
1988 • 251 citations
Memantine displaces [3H]MK-801 at therapeutic concentrations in postmortem human frontal cortex
1989 • 251 citations
Glycine enhances NMDA-receptor mediated synaptic potentials in neocortical slices
1989 • 234 citations
Intra-ventricular infusion of the NMDA antagonist AP5 impairs performance on a non-spatial operant DRL task in the rat
1988 • 225 citations
Learning impairment in rats by N-methyl-D-aspartate receptor antagonists
1988 • 222 citations
N-Methyl-d-Aspartate Antagonists in the Treatment of Parkinson's Disease
1991 • 221 citations
Attenuation and reversal of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist, LY274614.
1993 • 214 citations
Comparison of the behavioral and biochemical effects of the NMDA receptor antagonists, MK-801 and phencyclidine
1989 • 205 citations
The excitatory amino acid antagonist d-CPP-ene (SDZ EAA-494) in patients with epilepsy
1993 • 194 citations
NMDA antagonist MK-801 impairs acquisition but not performance of spatial working and reference memory
1990 • 170 citations
A preliminary investigation of ibogaine: Case reports and recommendations for further study
1994 • 156 citations
The NMDA receptor antagonist MK-801 prevents long-lasting non-associative morphine tolerance in the rat
1992 • 155 citations
Potential Antidepressive Properties of Amantadine, Memantine and Bifemelane
1993 • 155 citations
NMDA receptor antagonists suppress behaviors but not norepinephrine turnover or locus coeruleus unit activity induced by opiate withdrawal
1991 • 147 citations
Differential behavioural and neurochemical effects of competitive and non-competitive NMDA receptor antagonists in rats
1992 • 140 citations
Biexponential kinetics of [3H]MK-801 binding: evidence for access to closed and open N-methyl-D-aspartate receptor channels.
1989 • 131 citations
Efficacy and tolerability of memantine in patients with dementia syndrome. A double-blind, placebo controlled trial.
1991 • 124 citations
D-serine antagonized phencyclidine- and MK-801-induced stereotyped behavior and ataxia
1990 • 120 citations
Glutamate antagonists prevent morphine withdrawal in mice and guinea pigs
1991 • 116 citations
Modulation of NMDA receptor-mediated responses by glycine and d-serine in the rat thalamus in vivo
1989 • 105 citations
Blockade of morphine-induced analgesia and tolerance in mice by MK-801
1993 • 99 citations
Antagonism of phencyclidine-induced hyperactivity by glycine in mice
1986 • 94 citations
Modulation of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist LY274614: assessment of opioid receptor changes.
1994 • 88 citations
The NMDA antagonist dizocilpine (MK801) attenuates motivational as well as somatic aspects of naloxone precipitated opioid withdrawal
1992 • 87 citations
Sensitive and rapid behavioral differentiation ofN-methyl-d-aspartate receptor antagonists
1994 • 83 citations
Opiate tolerance and dependence: recent findings and synthesis.
1991 • 82 citations
Selective memory impairment by phencyclidine in rats
1987 • 77 citations
A new computer program for detailed off-line analysis of swimming navigation in the Morris water maze
1992 • 75 citations
The mouse jumping test--a simple screening method to estimate the physical dependence capacity of analgesics.
1971 • 71 citations
The treatment of heroin addicts with dextromethorphan: a double-blind comparison of dextromethorphan with chlorpromazine.
1990 • 67 citations
The NMDA receptor antagonist MK-801 increases morphine catalepsy and lethality
1991 • 65 citations
Excitatory amino acid receptor antagonists and naloxone-precipitated withdrawal syndrome in morphine-dependent mice
1993 • 55 citations
1-aminocyclopropane carboxylic acid (ACPC) prevents mu and delta opioid tolerance
1994 • 54 citations
Pharmacological effects of the non-competitive NMDA antagonist CNS 1102 in normal volunteers.
1994 • 54 citations
Pharmacological profile of NPC 17742 [2R,4R,5S-(2-amino-4,5-(1, 2-cyclohexyl)-7-phosphonoheptanoic acid)], a potent, selective and competitive N-methyl-D-aspartate receptor antagonist.
1993 • 30 citations
Time-Dependent Disruption of Morphine Tolerance by Electroconvulsive Shock and Frontal Cortical Stimulation
1976 • 29 citations
Memantine has phencyclidine-like but not cocaine-like discriminative stimulus effects in rats
1992 • 28 citations
A rapid method for evaluating the behavioral effects of phencyclidine-like dissociative anesthetics in mice
1991 • 26 citations
Dextrorphan blocks long- but not short-term memory in a passive avoidance task in rats
1991 • 22 citations