[3H]MK‐801 Labels a Site on the N‐Methyl‐D‐Aspartate Receptor Channel Complex in Rat Brain Membranes

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Magnesium gates glutamate-activated channels in mouse central neurones

1984 • 3,999 citations

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

1976 • 2,883 citations

Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

1984 • 2,822 citations

Excitatory Amino Acid Transmitters

1981 • 2,488 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

The physiology of excitatory amino acids in the vertebrate central nervous system

1987 • 1,718 citations

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1984 • 1,689 citations

The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate

1983 • 1,400 citations

Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain

1985 • 1,294 citations

Zinc Selectively Blocks the Action of N -Methyl-D-Aspartate on Cortical Neurons

1987 • 678 citations

Hypoglycemia-Induced Neuronal Damage Prevented by an N -Methyl-D-Aspartate Antagonist

1985 • 673 citations

Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil

1987 • 647 citations

Possible Therapeutic Applications of Antagonists of Excitatory Amino acid Neurotransmitters

1985 • 558 citations

Anticonvulsant activity of (+)‐5‐methyl‐10, 11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

1982 • 496 citations

Quantitative studies on some antagonists of N‐methyl D‐aspartate in slices of rat cerebral cortex

1985 • 487 citations

The novel anticonvulsant MK‐801 binds to the activated state of the N‐methyl‐<scp>d</scp>‐aspartate receptor in rat brain

1987 • 452 citations

Selective depression of excitatory amino acid induced depolarizations by magnesium ions in isolated spinal cord preparations.

1980 • 398 citations

Specific [3H]phencyclidine binding in rat central nervous system.

1979 • 382 citations

1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs.

1986 • 379 citations

Pharmacological and autoradiographic discrimination of sigma and phencyclidine receptor binding sites in brain with (+)-[3H]SKF 10,047, (+)-[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine and [3H]-1-[1-(2-thienyl)cyclohexyl]piperidine.

1986 • 339 citations

L-Glutamate has higher affinity than other amino acids for [3H]-D-AP5 binding sites in rat brain membranes

1984 • 293 citations

Receptors for the excitatory amino acids in the mammalian central nervous system

1983 • 292 citations

Interaction of phencyclidine ("angel dust") with a specific receptor in rat brain membranes.

1979 • 263 citations

Ketamine and phencyclidine cause a voltage-dependent block of responses to l-aspartic acid

1985 • 261 citations

Effects of phencyclidine on [3H]catecholamine and [3H]serotonin uptake in synaptosomal preparations from rat brain

1977 • 214 citations

Naloxone-inaccessible sigma receptor in rat central nervous system.

1983 • 214 citations

Binding of [3H]3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid to rat brain membranes: a selective, high-affinity ligand for N-methyl-D-aspartate receptors.

1987 • 203 citations

Psychotomimetic opiate receptors labeled and visualized with (+)-[3H]3-(3-hydroxyphenyl)-N-(1-propyl)piperidine.

1984 • 199 citations

Radioligand binding to central phencyclidine recognition sites is dependent on excitatory amino acid receptor agonists

1986 • 182 citations

Ketamine acts as a non-competitive N-methyl-d-aspartate antagonist on frog spinal cord in vitro

1985 • 180 citations

Phencyclidine and related drugs bind to the activated receptor-channel complex in rat brain membranes

1987 • 170 citations

Stereoisomers of N -Allylnormetazocine: Phencyclidine-Like Behavioral Effects in Squirrel Monkeys and Rats

1982 • 165 citations

[3H]TCP: a new tool with high affinity for the PCP receptor in rat brain

1983 • 156 citations

Differential effects of dextrorphan and levorphanol on the excitation of rat spinal neurons by amino acids

1985 • 153 citations

High correlation between the localization of [3H]TCP binding and NMDA receptors

1986 • 128 citations

Phencyclidine and σ opiate receptors in brain: Biochemical and autoradiographical differentiation

1985 • 124 citations

Subjective effects of narcotic antagonists cyclazocine and nalorphine on the Addiction Research Center Inventory (ARCI)

1970 • 124 citations

[3H]CPP, a new competitive ligand for NMDA receptors

1986 • 108 citations

Biochemical properties of the brain phencyclidine receptor

1982 • 86 citations

Autoradiography of d-2-[3H]amino-5-phosphonopentanoate binding sites in rat brain

1984 • 83 citations

Stereotyped behavior correlates better than ataxia with phencyclidine-receptor interactions

1986 • 79 citations

Anticonvulsant properties of phencyclidine-like drugs in mice

1985 • 76 citations

Stereoisomers of [3H]-N-allylnormetazocine bind to different sites in mouse brain.

1984 • 71 citations

Quantitative localization of [3H]TCP binding in rat brain by light microscopy autoradiography

1985 • 53 citations

Autoradiographic distribution of phencyclidine receptors in the rat brain using [3H]1-(1-(2-thienyl)cyclohexyl)piperidine ([3H]TCP)

1986 • 50 citations

Phencyclidine (PCP) receptors: autoradiographic localization in brain with the selective ligand, [3H]TCP

1986 • 49 citations

Effects of phencyclidine (PCP)-like drugs on turning behavior, 3H-dopamine uptake, and 3H-PCP binding

1985 • 49 citations

Characterization of specific binding sites for [3H](d)-N-allylnormetazocine in rat brain membranes.

1985 • 46 citations

Actions of phencyclidine on rat locus coeruleus neurones in vitro

1986 • 33 citations

The effect of the dioxolanes on amino acid induced excitation in the mammalian spinal cord

1984 • 28 citations

HR 375: A potential antipsychotic drug that interacts with dopamine D2 receptors and σ-receptors in the brain

1986 • 24 citations

Autoradiographic distribution of [3H]dexoxadrol (a phencyclidine-related ligand) binding sites in rat and human brain

1985 • 16 citations

Pharmacological effects of HR 375: A new potential antipsychotic agent

1985 • 11 citations

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