Parkin Binds to α/β Tubulin and Increases their Ubiquitination and Degradation

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1998 • 5,063 citations

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

2000 • 3,559 citations

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

2000 • 1,975 citations

An Unfolded Putative Transmembrane Polypeptide, which Can Lead to Endoplasmic Reticulum Stress, Is a Substrate of Parkin

2001 • 1,048 citations

Ubiquitination of a New Form of α-Synuclein by Parkin from Human Brain: Implications for Parkinson's Disease

2001 • 1,036 citations

Parkin functions as an E2-dependent ubiquitin– protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

2000 • 975 citations

Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in muscle, and mallory bodies in alcoholic liver disease

1988 • 541 citations

Lactacystin, Proteasome Function, and Cell Fate

1998 • 420 citations

Autoregulation of tubulin expression is achieved through specific degradation of polysomal tubulin mRNAs

1987 • 206 citations

Dominant effects of tubulin overexpression in Saccharomyces cerevisiae.

1989 • 191 citations

Parkin and CASK/LIN-2 Associate via a PDZ-mediated Interaction and Are Co-localized in Lipid Rafts and Postsynaptic Densities in Brain

2002 • 183 citations

Parkin and the Molecular Pathways of Parkinson's Disease

2001 • 160 citations

Filaments of Lewy bodies contain insoluble cytoskeletal elements.

1992 • 130 citations

ASSOCIATION BETWEEN EARLY-ONSET PARKINSON'S DISEASE AND MUTATIONS IN THE PARKIN GENE

2000 • 124 citations

A small amphipathic alpha -helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5

2000 • 121 citations

Rotenone inhibition of tubulin self-assembly

1978 • 116 citations

Rotenone inhibition of spindle microtubule assembly in mammalian cells

1974 • 114 citations

Microtubules and axonal growth

1997 • 113 citations

[11] Purification of brain microtubules and microtubule-associated protein 1 using taxol

1986 • 85 citations

Microtubule Transport in the Axon

2002 • 53 citations

Intermediate filament-ubiquitin diseases: implications for cell sanitization.

1989 • 27 citations