Cbl-mediated Negative Regulation of the Syk Tyrosine Kinase

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Protein modules and signalling networks

1995 • 2,447 citations

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.

1994 • 886 citations

The structure of an antigenic determinant in a protein

1984 • 841 citations

The Phosphotyrosine Interaction Domains of X11 and FE65 Bind to Distinct Sites on the YENPTY Motif of Amyloid Precursor Protein

1996 • 480 citations

Antigen and Fc receptor signaling. The awesome power of the immunoreceptor tyrosine-based activation motif (ITAM).

1995 • 463 citations

T cell antigen receptor signal transduction

1997 • 390 citations

Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient Mice

1998 • 371 citations

Similarity of sli-1 , a Regulator of Vulval Development in C. elegans , to the Mammalian Proto-Oncogene c- cbl

1995 • 298 citations

Oncogenes, Growth Factors, and Signal Transduction

1989 • 296 citations

The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor α

1998 • 257 citations

Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts.

1993 • 257 citations

The Product of the Proto-Oncogene c- cbl : A Negative Regulator of the Syk Tyrosine Kinase

1997 • 251 citations

The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif.

1991 • 234 citations

The Cbl Phosphotyrosine-binding Domain Selects a D(N/D)XpY Motif and Binds to the Tyr292Negative Regulatory Phosphorylation Site of ZAP-70

1997 • 215 citations

Activation-Induced Ubiquitination of the T Cell Antigen Receptor

1992 • 213 citations

A Novel Phosphotyrosine-binding Domain in the N-terminal Transforming Region of Cbl Interacts Directly and Selectively with ZAP-70 in T Cells

1996 • 201 citations

CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation.

1996 • 200 citations

The SH3 Domain-binding T Cell Tyrosyl Phosphoprotein p120

1995 • 186 citations

Stimulation through the T Cell Receptor Induces Cbl Association with Crk Proteins and the Guanine Nucleotide Exchange Protein C3G

1996 • 181 citations

Differential Intrinsic Enzymatic Activity of Syk and Zap-70 Protein-tyrosine Kinases

1996 • 179 citations

p120 Is a Major Substrate of Tyrosine Phosphorylation upon B Cell Antigen Receptor Stimulation and Interacts in Vivo with Fyn and Syk Tyrosine Kinases, Grb2 and Shc Adaptors, and the p85 Subunit of Phosphatidylinositol 3-Kinase

1996 • 170 citations

Tyrosine Phosphorylation of Cbl upon Epidermal Growth Factor (EGF) Stimulation and Its Association with EGF Receptor and Downstream Signaling Proteins

1996 • 166 citations

c-Cbl Is Transiently Tyrosine-phosphorylated, Ubiquitinated, and Membrane-targeted following CSF-1 Stimulation of Macrophages

1996 • 163 citations

Characterization of Monoclonal Antibodies Against Cell Surface Molecules Associated with Cytotoxic Activity of Natural and Activated Killer Cells and Cloned CTL Lines

1983 • 155 citations

Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex.

1994 • 148 citations

Distinct Tyrosine Phosphorylation Sites in ZAP-70 Mediate Activation and Negative Regulation of Antigen Receptor Function

1996 • 139 citations

Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes.

1996 • 130 citations

Protein Kinase C μ (PKCμ) Associates with the B Cell Antigen Receptor Complex and Regulates Lymphocyte Signaling

1996 • 130 citations

Activation-dependent ubiquitination of a T cell antigen receptor subunit on multiple intracellular lysines.

1994 • 125 citations

Interactions of Drosophila Cbl with Epidermal Growth Factor Receptors and Role of Cbl in R7 Photoreceptor Cell Development

1997 • 123 citations

Coordinated Regulation of the Tyrosine Phosphorylation of Cbl by Fyn and Syk Tyrosine Kinases

1998 • 120 citations

Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk

1997 • 120 citations

Cell surface control of the multiubiquitination and deubiquitination of high-affinity immunoglobulin E receptors.

1993 • 119 citations

Phosphotyrosine Binding Domain-Dependent Upregulation of the Platelet-Derived Growth Factor Receptor α Signaling Cascade by Transforming Mutants of Cbl: Implications for Cbl’s Function and Oncogenicity

1997 • 119 citations

Identification of the Major Tyrosine Kinase Substrate in Signaling Complexes Formed after Engagement of Fcγ Receptors

1995 • 117 citations

Transmembrane signaling by antigen receptors of B and T lymphocytes

1995 • 109 citations

Protein tyrosine kinases Syk and ZAP-70 display distinct requirements for Src family kinases in immune response receptor signal transduction.

1997 • 103 citations

Both the SH2 and SH3 domains of human CRK protein are required for neuronal differentiation of PC12 cells.

1993 • 100 citations

Characterization of Cbl tyrosine phosphorylation and a Cbl-Syk complex in RBL-2H3 cells.

1996 • 92 citations

Enhancement of Lymphocyte Responsiveness by a Gain-of-Function Mutation of ZAP-70

1996 • 91 citations

The Cbl Protooncogene Product: From an Enigmatic Oncogene to Center Stage of Signal Transduction

1997 • 88 citations

The protein product of the c-cbl oncogene rapidly complexes with the EGF receptor and is tyrosine phosphorylated following EGF stimulation.

1995 • 76 citations

Antisense Repression of Proto-oncogene c-Cbl Enhances Activation of the JAK-STAT Pathway but Not the Ras Pathway in Epidermal Growth Factor Receptor Signaling

1997 • 74 citations

EGF receptor binding and transformation by v-cbl is ablated by the introduction of a loss-of-function mutation from the Caenorhabditis elegans sli-1 gene

1997 • 72 citations

High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif

1997 • 67 citations

Specificity in recognition of phosphopeptides by src-homology 2 domains

1994 • 66 citations

D-Cbl, the Drosophila homologue of the c-Cbl proto-oncogene, interacts with the Drosophila EGF receptor in vivo, despite lacking C-terminal adaptor binding sites

1997 • 66 citations

Molecules in focus: The c-Cbl oncoprotein

1998 • 56 citations

Direct T Cell Activation by Chimeric Single Chain Fv-Syk Promotes Syk-Cbl Association and Cbl Phosphorylation

1997 • 34 citations

Differential Activation of the Tyrosine Kinases ZAP-70 and Syk After FcγRI Stimulation

1997 • 33 citations

A rearrangement of the c-cbl proto-oncogene in HUT78 T-lymphoma cells results in a truncated protein.

1992 • 29 citations