Cbl-b-dependent Coordinated Degradation of the Epidermal Growth Factor Receptor Signaling Complex

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Themes and variations on ubiquitylation

2001 • 1,475 citations

125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.

1976 • 1,293 citations

RING Finger Proteins

2000 • 1,216 citations

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

1999 • 1,134 citations

The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

1999 • 1,045 citations

Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53

2000 • 1,026 citations

Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1

1999 • 1,000 citations

Ubiquitin Protein Ligase Activity of IAPs and Their Degradation in Proteasomes in Response to Apoptotic Stimuli

2000 • 989 citations

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

1998 • 865 citations

Structure of a c-Cbl–UbcH7 Complex

2000 • 824 citations

Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase

1999 • 771 citations

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

2000 • 656 citations

Cbl-b regulates the CD28 dependence of T-cell activation

2000 • 607 citations

Chemotherapy augments TRAIL-induced apoptosis in breast cell lines.

1999 • 557 citations

SH2/SH3 signaling proteins

1994 • 457 citations

Caspase-dependent Cleavage of Signaling Proteins during Apoptosis

1998 • 420 citations

Reconstitution of G ₁ Cyclin Ubiquitination with Complexes Containing SCF ^Grr1 and Rbx1

1999 • 385 citations

Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient Mice

1998 • 371 citations

Ubiquitination and Endocytosis of Plasma Membrane Proteins: Role of Nedd4/Rsp5p Family of Ubiquitin-Protein Ligases

2000 • 356 citations

Altered thymic positive selection and intracellular signals in Cbl-deficient mice

1998 • 343 citations

Ligand-induced Ubiquitination of the Epidermal Growth Factor Receptor Involves the Interaction of the c-Cbl RING Finger and UbcH7

1999 • 328 citations

MDM2 interacts with MDMX through their RING finger domains

1999 • 319 citations

The RING Finger of c-Cbl Mediates Desensitization of the Epidermal Growth Factor Receptor

1999 • 308 citations

The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor.

1996 • 307 citations

Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase

1999 • 299 citations

Similarity of sli-1 , a Regulator of Vulval Development in C. elegans , to the Mammalian Proto-Oncogene c- cbl

1995 • 298 citations

The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation

1999 • 291 citations

The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor α

1998 • 257 citations

The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif.

1991 • 234 citations

Siah-1 N-Terminal RING Domain Is Required for Proteolysis Function, and C-Terminal Sequences Regulate Oligomerization and Binding to Target Proteins

1999 • 234 citations

Identification of a novel ubiquitin conjugation motif, required for ligand-induced internalization of the growth hormone receptor

1999 • 194 citations

Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene.

1995 • 185 citations

Threonine Phosphorylation Diverts Internalized Epidermal Growth Factor Receptors from a Degradative Pathway to the Recycling Endosome

2000 • 179 citations

Endocytosis and Degradation of the Growth Hormone Receptor Are Proteasome-dependent

2000 • 173 citations

Tyrosine Phosphorylation of Cbl upon Epidermal Growth Factor (EGF) Stimulation and Its Association with EGF Receptor and Downstream Signaling Proteins

1996 • 166 citations

c-Cbl Is Transiently Tyrosine-phosphorylated, Ubiquitinated, and Membrane-targeted following CSF-1 Stimulation of Macrophages

1996 • 163 citations

sli-1, a negative regulator of let-23-mediated signaling in C. elegans.

1995 • 149 citations

p120 Is a Cytosolic Adapter Protein That Associates with Phosphoinositide 3-Kinase in Response to Epidermal Growth Factor in PC12 and Other Cells

1996 • 143 citations

The Evolutionarily Conserved N-terminal Region of Cbl Is Sufficient to Enhance Down-regulation of the Epidermal Growth Factor Receptor

2000 • 143 citations

The epidermal growth factor receptor is covalently linked to ubiquitin.

1995 • 130 citations

Activation-dependent ubiquitination of a T cell antigen receptor subunit on multiple intracellular lysines.

1994 • 125 citations

Interactions of Drosophila Cbl with Epidermal Growth Factor Receptors and Role of Cbl in R7 Photoreceptor Cell Development

1997 • 123 citations

The Cbl Proto-Oncogene Product Negatively Regulates the Src-Family Tyrosine Kinase Fyn by Enhancing Its Degradation

2000 • 122 citations

cbl-b inhibits epidermal growth factor receptor signaling

1999 • 121 citations

cbl-3: a new mammalian cbl family protein

1999 • 117 citations

CSF-1 stimulated multiubiquitination of the CSF-1 receptor and of Cbl follows their tyrosine phosphorylation and association with other signaling proteins

1999 • 90 citations

The RING Finger Domain of Cbl Is Essential for Negative Regulation of the Syk Tyrosine Kinase

2000 • 89 citations

The Cbl Protooncogene Product: From an Enigmatic Oncogene to Center Stage of Signal Transduction

1997 • 88 citations

The Cbl Family of Signal Transduction Molecules

1997 • 67 citations

D-Cbl, the Drosophila homologue of the c-Cbl proto-oncogene, interacts with the Drosophila EGF receptor in vivo, despite lacking C-terminal adaptor binding sites

1997 • 66 citations

c‐Cbl: A regulator of T cell receptor‐mediated signalling

1998 • 63 citations

Molecular cloning and characterization of a novel cbl-family gene, cbl-c

1999 • 58 citations

cbl-b Inhibits EGF-Receptor-Induced Apoptosis by Enhancing Ubiquitination and Degradation of Activated Receptors

1999 • 53 citations

The proto-oncogene c-Cbl is a negative regulator of DNA synthesis initiated by both receptor and cytoplasmic tyrosine kinases

1999 • 24 citations

A third human CBL gene is on chromosome 19.

1998 • 16 citations