Impact of Endoplasmic Reticulum Stress Pathway on Pancreatic β-Cells and Diabetes Mellitus

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

2003 • 3,886 citations

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

2000 • 3,071 citations

Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

2000 • 2,831 citations

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1998 • 1,972 citations

Aggresomes, inclusion bodies and protein aggregation

2000 • 1,881 citations

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

2002 • 1,296 citations

Cross-Talk between Two Cysteine Protease Families

2000 • 1,158 citations

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.

1992 • 1,156 citations

ATF6 Activated by Proteolysis Binds in the Presence of NF-Y (CBF) Directly to thecis-Acting Element Responsible for the Mammalian Unfolded Protein Response

2000 • 921 citations

Tripartite Management of Unfolded Proteins in the Endoplasmic Reticulum

2000 • 917 citations

β-Cell death during progression to diabetes

2001 • 883 citations

A choice of death - the signal-transduction of immune-mediated beta-cell apoptosis

2001 • 880 citations

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

2002 • 858 citations

Activation of Caspase-12, an Endoplastic Reticulum (ER) Resident Caspase, through Tumor Necrosis Factor Receptor-associated Factor 2-dependent Mechanism in Response to the ER Stress

2001 • 832 citations

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

1998 • 782 citations

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

2002 • 724 citations

Signals from the Stressed Endoplasmic Reticulum Induce C/EBP-Homologous Protein (CHOP/GADD153)

1996 • 671 citations

Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway

2001 • 594 citations

The unfolded protein response in nutrient sensing and differentiation

2002 • 592 citations

Coupling Endoplasmic Reticulum Stress to the Cell Death Program

2001 • 584 citations

A mutation in the insulin 2 gene induces diabetes with severe pancreatic β-cell dysfunction in the Mody mouse

1999 • 555 citations

Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells.

2002 • 516 citations

A Novel Locus, Mody4, Distal to D7Mit189 on Chromosome 7 Determines Early-Onset NIDDM in Nonobese C57BL/6 (Akita) Mutant Mice

1997 • 506 citations

Human caspase 12 has acquired deleterious mutations

2002 • 348 citations

CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest.

1994 • 331 citations

Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells

1996 • 317 citations

Compensatory responses in mice carrying a null mutation for Ins1 or Ins2.

2001 • 134 citations

Mapping of murine diabetogenic gene mody on chromosome 7 at D7Mit258 and its involvement in pancreatic islet and beta cell development during the perinatal period.

1998 • 96 citations