Oncostatin M Stimulates Transcription of the Human α2(I) Collagen Gene via the Sp1/Sp3-binding Site

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1991 • 2,362 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

COLLAGENS: Molecular Biology, Diseases, and Potentials for Therapy

1995 • 1,599 citations

In Vivo Footprinting of a Muscle Specific Enhancer by Ligation Mediated PCR

1989 • 972 citations

A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-β

1988 • 620 citations

THE FAMILY OF COLLAGEN GENES

1990 • 511 citations

Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4.

1992 • 498 citations

Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism.

1991 • 437 citations

Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6.

1991 • 372 citations

Dual Oncostatin M (OSM) Receptors

1996 • 371 citations

An AP-1 Binding Sequence Is Essential for Regulation of the Human α2(I) Collagen (COL1A2) Promoter Activity by Transforming Growth Factor-β

1996 • 312 citations

Transforming growth factor-beta stimulates alpha 2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site.

1994 • 311 citations

Ciliary neurotropic factor, interleukin 11, leukemia inhibitory factor, and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer gp130.

1994 • 239 citations

Purification and characterization of cytostatic lymphokines produced by activated human T lymphocytes. Synergistic antiproliferative activity of transforming growth factor beta 1, interferon-gamma, and oncostatin M for human melanoma cells.

1987 • 218 citations

Modulation by recombinant interleukin 1 of synthesis of types I and III collagens and associated procollagen mRNA levels in cultured human cells.

1987 • 195 citations

Selective upregulation of platelet-derived growth factor alpha receptors by transforming growth factor beta in scleroderma fibroblasts.

1992 • 181 citations

Interleukin-10 modulates type I collagen and matrix metalloprotease gene expression in cultured human skin fibroblasts.

1994 • 181 citations

Tumor necrosis factor-alpha and interferon-gamma suppress the activation of human type I collagen gene expression by transforming growth factor-beta 1. Evidence for two distinct mechanisms of inhibition at the transcriptional and posttranscriptional levels.

1990 • 178 citations

Signal transduction through gp130 that is shared among the receptors for the interleukin 6 related cytokine subfamily

1994 • 173 citations

The Mitogen-activated Protein Kinase and JAK-STAT Signaling Pathways Are Required for an Oncostatin M-responsive Element-mediated Activation of Matrix Metalloproteinase 1 Gene Expression

1997 • 172 citations

Epidermal growth factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver.

1994 • 152 citations

Transcriptional Regulation of the Human α2(I) Collagen Gene

1996 • 148 citations

Selective regulation of metalloproteinase inhibitor (TIMP-1) by oncostatin M in fibroblasts in culture.

1993 • 146 citations

A proline-rich TGF-beta-responsive transcriptional activator interacts with histone H3.

1995 • 132 citations

Characterization of a GC-rich Region Containing Sp1 Binding Site(s) as a Constitutive Responsive Element of the α2(I) Collagen Gene in Human Fibroblasts

1995 • 127 citations

Regulation of expression of the type I collagen genes

1993 • 121 citations

Developmental Abnormalities in Mice Transgenic for Bovine Oncostatin M

1995 • 120 citations

Overlapping Pathways Mediate the Opposing Actions of Tumor Necrosis Factor-α and Transforming Growth Factor-β on α2(I) Collagen Gene Transcription

1995 • 110 citations

Complex and diversified regulatory programs control the expression of vertebrate collagen genes ¹

1990 • 100 citations

Two Sp1-binding Sites Mediate cAMP-induced Transcription of the Bovine CYP11A Gene through the Protein Kinase A Signaling Pathway

1995 • 96 citations

Direct demonstration of transcriptional activation of collagen gene expression in systemic sclerosis fibroblasts: Insensitivity to TGFβ1 stimulation

1992 • 95 citations

Epidermal Growth Factor Stimulation of the Human Gastrin Promoter Requires Sp1

1995 • 85 citations

Novel Role for Sp1 in Phorbol Ester Enhancement of Human Platelet Thromboxane Receptor Gene Expression

1996 • 78 citations

Oncostatin-M stimulates tyrosine protein phosphorylation in parallel with the activation of p42MAPK/ERK-2 in Kaposi's cells. Evidence that this pathway is important in Kaposi cell growth.

1993 • 64 citations

Oncostatin M

1992 • 64 citations

Oncostatin M Stimulates Collagen and Glycosaminoglycan Production by Cultured Normal Dermal Fibroblasts: Insensitivity of Sclerodermal and Keloidal Fibroblasts

1995 • 62 citations

Basic fibroblast growth factor inhibits basal and transforming growth factor-beta induced collagen alpha 2(I) gene expression in scleroderma and normal fibroblasts.

1997 • 44 citations

Oncostatin M stimulates urokinase-type plasminogen activator activity in human synovial fibroblasts

1991 • 42 citations

Antagonistic Regulation of a Proline-rich Transcription Factor by Transforming Growth Factor β and Tumor Necrosis Factor α

1996 • 37 citations

Persistent effect of TGF-β1 on extracellular matrix gene expression in human dermal fibroblasts

1990 • 35 citations

Identification of an upstream regulatory region essential for cell type-specific transcription of the pro-alpha 2(V) collagen gene (COL5A2).

1992 • 28 citations