Overlapping Pathways Mediate the Opposing Actions of Tumor Necrosis Factor-α and Transforming Growth Factor-β on α2(I) Collagen Gene Transcription

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B.

1989 • 1,660 citations

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

1991 • 1,630 citations

Transforming growth factor-beta in disease: the dark side of tissue repair.

1992 • 1,126 citations

Cell biology of extracellular matrix

1992 • 1,042 citations

Compilation of vertebrate-encoded transcription factors

1992 • 934 citations

Transcriptional regulation

1991 • 893 citations

TUMOR NECROSIS, CACHEXIA, SHOCK, AND INFLAMMATION: A COMMON MEDIATOR

1988 • 814 citations

Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis.

1991 • 794 citations

Transforming growth factor-beta: recent progress and new challenges.

1992 • 781 citations

Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta.

1987 • 736 citations

Prolonged activation of jun and collagenase genes by tumour necrosis factor-α

1989 • 726 citations

Sp1-mediated transcriptional activation is repressed by Sp3.

1994 • 692 citations

Human growth hormone as a reporter gene in regulation studies employing transient gene expression.

1986 • 667 citations

Detection of tumor necrosis factor α but not tumor necrosis factor β in rheumatoid arthritis synovial fluid and serum

1988 • 570 citations

Tenascin: cDNA cloning and induction by TGF-beta.

1988 • 453 citations

Transforming growth factor beta increases mRNA for matrix proteins both in the presence and in the absence of changes in mRNA stability.

1988 • 420 citations

Tumor necrosis factor receptor-mediated signaling pathways.

1994 • 389 citations

Transforming growth factor-beta stimulates alpha 2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site.

1994 • 311 citations

Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts.

1988 • 241 citations

Tumor necrosis factor alpha induces proteins that bind specifically to kappa B-like enhancer elements and regulate interleukin 2 receptor alpha-chain gene expression in primary human T lymphocytes.

1989 • 230 citations

Tumor necrosis factor-alpha and interferon-gamma suppress the activation of human type I collagen gene expression by transforming growth factor-beta 1. Evidence for two distinct mechanisms of inhibition at the transcriptional and posttranscriptional levels.

1990 • 178 citations

Transforming growth factor-beta response elements of the skeletal alpha-actin gene. Combinatorial action of serum response factor, YY1, and the SV40 enhancer-binding protein, TEF-1

1994 • 167 citations

The yeast transcription activator PRTF, a homolog of the mammalian serum response factor, is encoded by the MCM1 gene.

1989 • 160 citations

Negative regulation of Sp1 trans-activation is correlated with the binding of cellular proteins to the amino terminus of the Sp1 trans-activation domain.

1994 • 128 citations

Functional analysis of cis-acting DNA sequences controlling transcription of the human type I collagen genes.

1990 • 127 citations

Bi‐functional action of transforming growth factor‐β on DNA synthesis in early passage human fetal fibroblasts

1986 • 121 citations

Direct demonstration of transcriptional activation of collagen gene expression in systemic sclerosis fibroblasts: Insensitivity to TGFβ1 stimulation

1992 • 95 citations

Point mutations and small substitution mutations in three different upstream elements inhibit the activity of the mouse alpha 2(I) collagen promoter.

1988 • 84 citations

Tissue-specific expression of the mouse alpha 2(I) collagen promoter. Studies in transgenic mice and in tissue culture cells.

1992 • 78 citations

Minimal DNA sequences that control the cell lineage-specific expression of the pro alpha 2(I) collagen promoter in transgenic mice.

1992 • 71 citations

Stimulation of human synovial fibroblast DNA synthesis by recombinant human cytokines.

1988 • 64 citations