Direct demonstration of transcriptional activation of collagen gene expression in systemic sclerosis fibroblasts: Insensitivity to TGFβ1 stimulation

Current protocols in molecular biology

1988 • 7,584 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

Peptide growth factors are multifunctional

1988 • 835 citations

A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-β

1988 • 620 citations

Fibrogenic cytokines: the role of immune mediators in the development of scar tissue

1991 • 607 citations

Transforming growth factor β (TGFβ) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts

1987 • 579 citations

Increased Collagen Synthesis by Scleroderma Skin Fibroblasts In Vitro A POSSIBLE DEFECT IN THE REGULATION OR ACTIVATION OF THE SCLERODERMA FIBROBLAST

1974 • 545 citations

Chromatin structure and protein binding in the putative regulatory region of the c-myc gene in burkitt lymphoma

1984 • 443 citations

Selective upregulation of platelet-derived growth factor alpha receptors by transforming growth factor beta in scleroderma fibroblasts.

1992 • 181 citations

A strategy for determining the pathogenesis of systemic sclerosis. Is transforming growth factor beta the answer?

1989 • 181 citations

Tumor necrosis factor-alpha and interferon-gamma suppress the activation of human type I collagen gene expression by transforming growth factor-beta 1. Evidence for two distinct mechanisms of inhibition at the transcriptional and posttranscriptional levels.

1990 • 178 citations

Co-ordinate increase in the expression of type I and type III collagen genes in progressive systemic sclerosis fibroblasts

1986 • 173 citations

Transforming-growth-factor-β activation elements in the distal promoter regions of the rat α1 type I collagen gene

1991 • 138 citations

A STRATEGY FOR DETERMINING THE PATHOGENESIS OF SYSTEMIC SCLEROSIS: Is Transforming Growth Factor β the Answer?

1989 • 134 citations

Functional analysis of cis-acting DNA sequences controlling transcription of the human type I collagen genes.

1990 • 127 citations

Cecil Textbook of Medicine : 19th edition

1992 • 127 citations

Increased expression of type VI collagen genes in systemic sclerosis

1990 • 97 citations

Increased type I collagen mRNA levels in cultured scleroderma fibroblasts

1984 • 76 citations

Elevated proα2(I) collagen mRNA levels in cultured scleroderma fibroblasts result from an increased transcription rate of the corresponding gene

1987 • 57 citations

Elevated expression of c-myc proto-oncogene in scleroderma fibroblasts.

1988 • 51 citations

Systemic sclerosis (scleroderma)

1991 • 16 citations

Energy conversion by gravitational waves

1988 • 10 citations