Modulation by recombinant interleukin 1 of synthesis of types I and III collagens and associated procollagen mRNA levels in cultured human cells.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Film Detection Method for Tritium‐Labelled Proteins and Nucleic Acids in Polyacrylamide Gels

1974 • 8,693 citations

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

1985 • 1,594 citations

Cytoplasmic dot hybridization. Simple analysis of relative mRNA levels in multiple small cell or tissue samples.

1982 • 1,333 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

Transforming Growth Factor-β: Biological Function and Chemical Structure

1986 • 1,198 citations

Enhanced autoradiographic detection of ³²P and ¹²⁵I using intensifying screens and hypersensitized film

1977 • 947 citations

Interleukin 1, a potential regulator of fibroblast proliferation.

1982 • 835 citations

Cloning and expression of murine interleukin-1 cDNA in Escherichia coli

1984 • 820 citations

A cyclic AMP- and phorbol ester-inducible DNA element

1986 • 780 citations

Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells.

1986 • 632 citations

Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1).

1981 • 614 citations

Modifications of the diphenylamine reaction giving increased sensitivity and simplicity in the estimation of DNA

1974 • 608 citations

The estimation of two collagens from human dermis by interrupted gel electrophoresis

1976 • 564 citations

Articular Cartilage Biochemistry

1987 • 504 citations

Cloning and characterization of five overlapping cDNAs specific for the human proα 1(I) collagen chain

1982 • 496 citations

Interleukin 1 stimulates fibroblasts to produce granulocyte-macrophage colony-stimulating activity and prostaglandin E2.

1986 • 458 citations

Isolation of an interleukin‐1‐like factor from human joint effusions

1983 • 450 citations

Multiple biological activities of human recombinant interleukin 1.

1986 • 372 citations

Lymphocyte-Mediated Activation of Fibroblast Proliferation and Collagen Production

1978 • 358 citations

Regulation of Bone Formation

1983 • 339 citations

Selective inhibition of human diploid fibroblast collagen synthesis by interferons.

1984 • 336 citations

Lymphokine stimulation of collagen accumulation.

1976 • 322 citations

Specificities of Prostaglandins B1, F1α, and F2α Antigen-Antibody Reactions

1971 • 260 citations

Structure of a cDNA for the pro.alpha.2 chain of human type I procollagen. Comparison with chick cDNA for pro.alpha.2(I) identifies structurally conserved features of the protein and the gene

1983 • 252 citations

Binding and internalization of interleukin 1 by T cells. Direct evidence for high- and low-affinity classes of interleukin 1 receptor.

1986 • 194 citations

Stimulation of the proliferation of human bone cells in vitro by human monocyte products with interleukin-1 activity.

1985 • 174 citations

Mononuclear Cell-Conditioned Medium Containing Mononuclear Cell Factor (MCF), Homologous With Interleukin 1, Stimulates Collagen and Fibronectin Synthesis by Adherent Rheumatoid Synovial Cells: Effects of Prostaglandin E2 and Indomethacin

1985 • 165 citations

A quantitative collagen film collagenase assay for large numbers of samples

1980 • 157 citations

Purification and characterization of human interleukin‐1β expressed in recombinant Escherichia coli

1986 • 153 citations

Immune interferon suppresses levels of procollagen mRNA and type II collagen synthesis in cultured human articular and costal chondrocytes.

1986 • 151 citations

Similarity between the interleukin 1 receptors on a murine T-lymphoma cell line and on a murine fibroblast cell line.

1986 • 144 citations

Inhibition of collagen synthesis by mononuclear cell supernates.

1979 • 142 citations

Regulation of fibroblast proliferation and collagen synthesis by cytokines

1986 • 141 citations

Lymphocyte modulation of fibroblast function in vitro: stimulation and inhibition of collagen production by different effector molecules.

1984 • 139 citations

Influences of gamma interferon on synovial fibroblast-like cells. Ia induction and inhibition of collagen synthesis.

1985 • 134 citations

Identification of a high-affinity receptor for native human interleukin 1 beta and interleukin 1 alpha on normal human lung fibroblasts.

1987 • 132 citations

Transcriptional control of human diploid fibroblast collagen synthesis by γ-interferon

1984 • 132 citations

Release of interleukin‐1 from human synovial tissue in vitro

1985 • 126 citations

In vitro activation of human chondrocytes and synoviocytes by a human interleukin‐1‐like factor

1984 • 125 citations

Interactions among rheumatoid synovial cells and monocyte-macrophages: production of collagenase-stimulating factor by human monocytes exposed to concanavalin A or immunoglobulin Fc fragments.

1980 • 122 citations

Local Regulators of Skeletal Growth: A Perspective*

1985 • 121 citations

Cell Signalling Through Phospholipid Metabolism

1986 • 115 citations

Effects of human mononuclear cell factor on cultured rheumatoid synovial cells

1979 • 101 citations

Interleukin 1 increases collagen type IV production by murine mammary epithelial cells.

1985 • 85 citations

Immune interferon inhibits collagen synthesis by rheumatoid synovial cells associated wth decreaded levels of the procollagen mRNAs(FEBS 2156)

1985 • 83 citations

Specific bioactivities of monocyte-derived interleukin 1 alpha and interleukin 1 beta are similar to each other on cultured murine thymocytes and on cultured human connective tissue cells.

1986 • 82 citations

Stimulation of procollagenase synthesis parallels increases in cellular procollagenase mRNA in human articular chondrocytes exposed to recombinant interleukin 1β or phorbol ester

1987 • 81 citations

The effects of monocyte-conditioned medium and interleukin 1 on the synthesis of collagenous and non-collagenous proteins by mouse bone and human bone cells in vitro

1984 • 80 citations

Alterations in collagen production in mixed mononuclear leukocyte-fibroblast cultures.

1983 • 67 citations

Heberden Oration 1980: aspects of the cell biology of the rheumatoid synovial lesion.

1981 • 58 citations

Effects of products from macrophages, blood mononuclear cells and of retinol on collagenase secretion and collagen synthesis in chondrocyte culture

1982 • 54 citations

Stimulation of procollagenase synthesis in human rheumatoid synovial fibroblasts by mononuclear cell factor/interleukin 1

1985 • 47 citations

Effect of a monocyte cell factor (MCF) on collagen production in cultured articular chondrocytes: Role of prostaglandin E2

1984 • 46 citations

Effects of retinol and dexamethasone on cytokine-mediated control of metalloproteinases and their inhibitors by human articular chondrocytes and synovial cells in culture

1983 • 36 citations

The stimulations of arachidonic acid metabolism by recombinant murine interleukin 1 and tumor promoters or 1-oleoyl-2-acetyl-glycerol are synergistic.

1985 • 31 citations

An RFLP associated with the human type III collagen gene (COL3A1)

1985 • 30 citations

Pulmonary macrophages alter the collagen phenotype of lung fibroblasts

1981 • 19 citations

Enhanced production of prostaglandins and plasminogen activator during activation of human articular chondrocytes by products of mononuclear cells

1984 • 15 citations

Adenylate cyclase of human articular chondrocytes. Responsiveness to prostaglandins and other hormones

1982 • 13 citations