The A- and B-type cyclins of Drosophila are accumulated and destroyed in temporally distinct events that define separable phases of the G2-M transition.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

1986 • 6,284 citations

Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes

1971 • 1,553 citations

Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

1983 • 1,506 citations

Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

1989 • 1,237 citations

Cyclin synthesis drives the early embryonic cell cycle

1989 • 1,223 citations

Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

1987 • 1,153 citations

Studies of nuclear and cytoplasmic behaviour during the five mitotic cycles that precede gastrulation in Drosophila embryogenesis

1983 • 1,034 citations

Comparison of the consensus sequence flanking translational start sites inDrosophilaand vertebrates

1987 • 966 citations

Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2

1989 • 920 citations

Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+

1988 • 885 citations

An interactive graphics program for comparing and aligning nucleic acid and amino acid sequences

1982 • 801 citations

Spatial and temporal patterns of neurogenesis in the central nervous system of Drosophila melanogaster

1988 • 720 citations

cdc2 protein kinase is complexed with both cyclin A and B: Evidence for proteolytic inactivation of MPF

1989 • 666 citations

Cell cycle dynamics of an M-phase-specific cytoplasmic factor in Xenopus laevis oocytes and eggs.

1984 • 575 citations

Genetic control of cell division patterns in the Drosophila embryo

1989 • 567 citations

Mitotic domains reveal early commitment of cells in Drosophila embryos

1989 • 554 citations

MPF from starfish oocytes at first meiotic metaphase is a heterodimer containing one molecule of cdc2 and one molecule of cyclin B.

1989 • 550 citations

cdc2 is a component of the M phase-specific histone H1 kinase: Evidence for identity with MPF

1988 • 535 citations

The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytes

1986 • 534 citations

Reversible tyrosine phosphorylation of cdc2: Dephosphorylation accompanies activation during entry into mitosis

1989 • 453 citations

Functionally homologous cell cycle control genes in budding and fission yeast

1982 • 410 citations

Expression and function of Drosophila cyclin a during embryonic cell cycle progression

1989 • 399 citations

Purification of MPF from starfish: Identification as the H1 histone kinase p34cdc2 and a possible mechanism for its periodic activation

1989 • 366 citations

A cytoplasmic clock with the same period as the division cycle in Xenopus eggs.

1980 • 358 citations

Fission yeast p13 blocks mitotic activation and tyrosine dephosphorylation of the Xenopus cdc2 protein kinase

1989 • 327 citations

Activation at M-phase of a protein kinase encoded by a starfish homologue of the cell cycle control gene cdc2+

1988 • 314 citations

Dephosphorylation and activation of Xenopusp34cdc2 protein kinase during the cell cycle

1989 • 300 citations

Localization of antigenic determinants in whole Drosophila embryos

1983 • 266 citations

The role of cyclin B in meiosis I.

1989 • 241 citations

Involvement of cdc13+ in mitotic control in Schizosaccharomyces pombe: possible interaction of the gene product with microtubules.

1988 • 234 citations

Optimal spatial requirements for the location of basic residues in peptide substrates for the cyclic AMP-dependent protein kinase.

1980 • 227 citations

Nuclear and cytoplasmic mitotic cycles continue in Drosophila embryos in which DNA synthesis is inhibited with aphidicolin.

1988 • 222 citations

Cloning and sequencing of the cyclin-related Cdc13 + gene and a cytological study of its role in fission yeast mitosis

1988 • 220 citations

Molecular cloning and characterization of the mRNA for cyclin from sea urchin eggs.

1987 • 220 citations

The dissociation of nuclear and centrosomal division in gnu, a mutation causing giant nuclei in Drosophila

1986 • 186 citations

Directing Cell Division During Development

1989 • 186 citations

Interaction between cdc13+ and cdc2+ in the control of mitosis in fission yeast; dissociation of the G1 and G2 roles of the cdc2+ protein kinase.

1987 • 177 citations

Cyclin synthesis, modification and destruction during meiotic maturation of the starfish oocyte

1987 • 176 citations

Studies on the appearance and nature of a maturation-inducing factor in the cytoplasm of amphibian oocytes exposed to progesterone

1974 • 157 citations

The role of cyclin synthesis, modification and destruction in the control of cell division

1989 • 154 citations

Molecular features of colchicine associated with antimitotic activity and inhibition of tubulin polymerization

1976 • 141 citations

Transcripts of one of two Drosophila cyclin genes become localized in pole cells during embryogenesis

1989 • 120 citations

Proteins shifting from the cytoplasm into the nuclei during early embryogenesis of Drosophila melanogaster

1984 • 70 citations