Chimeric Granulocyte/Macrophage Colony-stimulating Factor/Transforming Growth Factor-β (TGF-β) Receptors Define a Model System for Investigating the Role of Homomeric and Heteromeric Receptors in TGF-β Signaling

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension

1989 • 3,067 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

Signal-Dependent Membrane Protein Trafficking in the Endocytic Pathway

1993 • 808 citations

Cloning of a TGF$beta; type I receptor that forms a heteromeric complex with the TGF$beta; type II receptor

1993 • 779 citations

Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.

1994 • 737 citations

Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor.

1989 • 711 citations

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

1995 • 682 citations

Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-β receptor system

1991 • 661 citations

Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors

1993 • 656 citations

Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor.

1990 • 650 citations

Expression cloning and characterization of the TGF-β type III receptor

1991 • 638 citations

Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor beta: a proposed model for indirect mitogenesis involving autocrine activity.

1986 • 541 citations

The TGF-β family and its composite receptors

1994 • 539 citations

The cell biology of transforming growth factor β

1990 • 537 citations

Inactivation of the Type II Receptor Reveals Two Receptor Pathways for the Diverse TGF-β Activities

1993 • 388 citations

Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.

1994 • 377 citations

Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta.

1994 • 324 citations

Concomitant loss of transforming growth factor (TGF)-beta receptor types I and II in TGF-beta-resistant cell mutants implicates both receptor types in signal transduction.

1990 • 319 citations

A Transforming Growth Factor β Type I Receptor that Signals to Activate Gene Expression

1994 • 296 citations

TGF-β-receptor-mediated signaling

1994 • 274 citations

Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells.

1985 • 262 citations

Responsiveness to transforming growth factor-beta (TGF-beta) restored by genetic complementation between cells defective in TGF-beta receptors I and II

1991 • 252 citations

Disruption of Transforming Growth Factor β Signaling by a Mutation That Prevents Transphosphorylation within the Receptor Complex

1995 • 217 citations

Signaling Activity of Transforming Growth Factor β Type II Receptors Lacking Specific Domains in the Cytoplasmic Region

1993 • 207 citations

Characterization of the human granulocyte-macrophage colony-stimulating factor receptor.

1988 • 202 citations

The types II and III transforming growth factor-beta receptors form homo-oligomers.

1994 • 199 citations

Induction of fibronectin gene transcription and mRNA is a primary response to growth-factor stimulation of AKR-2B cells.

1988 • 193 citations

Type beta transforming growth factor/growth inhibitor stimulates entry of monolayer cultures of AKR-2B cells into S phase after a prolonged prereplicative interval.

1985 • 191 citations

The transforming growth factor beta receptors types I, II, and III form hetero-oligomeric complexes in the presence of ligand.

1993 • 181 citations

Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype.

1993 • 181 citations

Inhibition of growth by transforming growth factor-beta following fusion of two nonresponsive human carcinoma cell lines. Implication of the type II receptor in growth inhibitory responses.

1992 • 176 citations

Receptors for the TGF-β superfamily: multiple polypeptides and serine/threonine kinases

1993 • 164 citations

Complementation between kinase-defective and activation-defective TGF-beta receptors reveals a novel form of receptor cooperativity essential for signaling.

1996 • 158 citations

Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors.

1993 • 155 citations

Transforming Growth Factor-β (TGF-β)-induced Down-regulation of Cyclin A Expression Requires a Functional TGF-β Receptor Complex

1995 • 154 citations

Two distinct transmembrane serine/threonine kinases from Drosophila melanogaster form an activin receptor complex.

1994 • 153 citations

Homomeric interactions between type II transforming growth factor-beta receptors.

1994 • 137 citations

Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor beta 1.

1995 • 131 citations

Transforming growth factor type β regulation of actin mRNA

1986 • 116 citations

The amino-terminal helix of GM-CSF and IL-5 governs high affinity binding to their receptors.

1991 • 103 citations

Serine/threonine kinase receptors

1994 • 89 citations

Overexpression of H-ras oncogene induces resistance to the growth-inhibitory action of transforming growth factor beta-1 (TGF-beta 1) and alters the number and type of TGF-beta 1 receptors in rat intestinal epithelial cell clones.

1992 • 86 citations

Reconstitution and transphosphorylation of TGF-beta receptor complexes.

1994 • 81 citations

Phosphorylation-dependent Interaction of the Cytoplasmic Domains of the Type I and Type II Transforming Growth Factor-β Receptors

1995 • 80 citations

Signaling Activity of Homologous and Heterologous Transforming Growth Factor-β Receptor Kinase Complexes

1995 • 78 citations

Modulation of monocyte type I transforming growth factor-beta receptors by inflammatory stimuli.

1991 • 72 citations

Distinct roles of the intracellular domains of transforming growth factor-beta type I and type II receptors in signal transduction.

1994 • 66 citations

Transforming growth factor-β receptor profiles of human and murine embryonic palate mesenchymal cells

1991 • 60 citations

Transforming growth factor β1 treatment of AKR-2B cells is coupled through a pertussis-toxin-sensitive G-protein(s)

1989 • 57 citations

The GS Domain of the Transforming Growth Factor-β Type-I Receptor Is Important in Signal Transduction

1995 • 53 citations

Biological effects and binding properties of transforming growth factor-β on human oral squamous cell carcinoma cells

1990 • 51 citations

Regulation of transforming growth factor beta 1 action by multiple transducing pathways: evidence for both G protein-dependent and -independent signaling.

1989 • 50 citations

The specificity of the transforming growth factor beta receptor kinases determined by a spatially addressable peptide library.

1995 • 43 citations

High Frequency of Resistance of Human Squamous Carcinoma Cells to the Anti-proliferative Action of Transforming Growth Factor β

1990 • 37 citations

A glycosylation-deficient endothelial cell mutant with modified responses to transforming growth factor-beta and other growth inhibitory cytokines: evidence for multiple growth inhibitory signal transduction pathways.

1993 • 30 citations

Distinct pathways regulate transforming growth factor β1‐stimulated proto‐oncogene and extracellular matrix gene expression

1990 • 28 citations

Transforming growth factor type β can act as a potent competence factor for AKR-2B cells

1987 • 12 citations

Dissociation of p34cdc2 complex formation from phosphorylation and histone H1 kinase activity.

1995 • 6 citations