Basic Fibroblast Growth Factor (bFGF) Enhances Functional Recovery Following Severe Spinal Cord Injury to the Rat

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury

1990 • 2,629 citations

Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms

1991 • 1,519 citations

Graded Histological and Locomotor Outcomes after Spinal Cord Contusion Using the NYU Weight-Drop Device versus Transection

1996 • 1,440 citations

Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys

1997 • 1,147 citations

Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion

1994 • 912 citations

Neuronal and Glial Apoptosis after Traumatic Spinal Cord Injury

1997 • 901 citations

Spinal Cord Repair in Adult Paraplegic Rats: Partial Restoration of Hind Limb Function

1996 • 764 citations

Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension.

1986 • 741 citations

Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data

1992 • 716 citations

Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture.

1986 • 696 citations

Depletion of Hematogenous Macrophages Promotes Partial Hindlimb Recovery and Neuroanatomical Repair after Experimental Spinal Cord Injury

1999 • 686 citations

The role of calcium in cell death

1981 • 637 citations

Cellular Delivery of Neurotrophin-3 Promotes Corticospinal Axonal Growth and Partial Functional Recovery after Spinal Cord Injury

1997 • 620 citations

Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo

1988 • 599 citations

Quantitative aspects of reactive gliosis: A review

1992 • 548 citations

Basic and acidic fibroblast growth factors have trophic effects on neurons from multiple CNS regions

1988 • 529 citations

Fibroblast growth factor and glutamate: opposing roles in the generation and degeneration of hippocampal neuroarchitecture

1989 • 492 citations

NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis

1991 • 462 citations

The relationships among the severity of spinal cord injury, residual neurological function, axon counts, and counts of retrogradely labeled neurons after experimental spinal cord injury

1995 • 402 citations

Endogenous Repair after Spinal Cord Contusion Injuries in the Rat

1997 • 398 citations

Apoptosis of microglia and oligodendrocytes after spinal cord contusion in rats

1997 • 371 citations

Axotomy of the rat facial nerve leads to increased CR3 complement receptor expression by activated microglial cells

1988 • 368 citations

Basic FGF reverses chemical and morphological deficits in the nigrostriatal system of MPTP-treated mice

1990 • 364 citations

The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats

1994 • 330 citations

Fibroblast growth factors: activities and significance of non-neurotrophin neurotrophic growth factors

1994 • 298 citations

Normal and Abnormal Calcium Homeostasis in Neurons: A Basis for the Pathophysiology of Traumatic and Ischemic Central Nervous System Injury

1996 • 297 citations

Excitatory amino acids rise to toxic levels upon impact injury to the rat spinal cord

1991 • 296 citations

Spinal cord contusion in the rat: Morphometric analyses of alterations in the spinal cord☆

1985 • 274 citations

Apoptosis and Expression of Bcl-2 after Compression Trauma to Rat Spinal Cord

1996 • 259 citations

A Quantitative Spatial Analysis of the Blood–Spinal Cord Barrier

1996 • 247 citations

Dose-dependent reduction of tissue loss and functional impairment after spinal cord trauma with the AMPA/kainate antagonist NBQX

1994 • 238 citations

Calcium, Excitotoxins, and Neuronal Death in the Brain^a

1989 • 235 citations

Correlative analyses of lesion development and functional status after graded spinal cord contusive injuries in the rat

1989 • 234 citations

Brain-Derived Neurotrophic Factor Stimulates Hindlimb Stepping and Sprouting of Cholinergic Fibers after Spinal Cord Injury

1998 • 218 citations

Distribution and time course of protein extravasation in the rat spinal cord after contusive injury

1989 • 218 citations

Glia protect hippocampal neurons against excitatory amino acid‐induced degeneration: Involvement of fibroblast growth factor

1990 • 211 citations

Methylprednisolone inhibition of TNF-α expression and NF-kB activation after spinal cord injury in rats

1998 • 209 citations

Basic FGF regulates the expression of a functional 71 kDa NMDA receptor protein that mediates calcium influx and neurotoxicity in hippocampal neurons

1993 • 198 citations

Effect of methylprednisolone in compression trauma to the feline spinal cord

1981 • 196 citations

Extracellular calcium ionic activity in experimental spinal cord contusion

1982 • 193 citations

Basic Fibroblast Growth Factor Prevents Thalamic Degeneration after Cortical Infarction

1991 • 191 citations

Collagen Containing Neurotrophin-3 (NT-3) Attracts Regrowing Injured Corticospinal Axons in the Adult Rat Spinal Cord and Promotes Partial Functional Recovery

1998 • 187 citations

Modeling of Acute Spinal Cord Injury in the Rat: Neuroprotection and Enhanced Recovery with Methylprednisolone, U-74006F and YM-14673

1994 • 186 citations

Delayed Treatment with Intravenous Basic Fibroblast Growth Factor Reduces Infarct Size following Permanent Focal Cerebral Ischemia in Rats

1995 • 180 citations

Intracisternal Basic Fibroblast Growth Factor (bFGF) Enhances Behavioral Recovery following Focal Cerebral Infarction in the Rat

1996 • 161 citations

Role of calcium in central nervous system injuries.

1992 • 159 citations

Basic Fibroblast Growth Factor Increases Long-Term Survival of Spinal Motor Neurons and Improves Respiratory Function after Experimental Spinal Cord Injury

1999 • 156 citations

N-Methyl-d-Aspartate Antagonist MK801 Improves Outcome Following Traumatic Spinal Cord Injury in Rats: Behavioral, Anatomic, and Neurochemical Studies

1988 • 155 citations

Amelioration of Functional Deficits from Spinal Cord Trauma with Systemically Administered NBQX, an Antagonist of Non-N-methyl-D-aspartate receptors

1996 • 152 citations

Glial fibrillary acidic protein in cryogenic lesions of the rat brain

1981 • 151 citations

Basic fibroblast growth factor and epidermal growth factor exert differential trophic effects on CNS neurons

1988 • 149 citations

Local Blockade of Sodium Channels by Tetrodotoxin Ameliorates Tissue Loss and Long-Term Functional Deficits Resulting from Experimental Spinal Cord Injury

1997 • 139 citations

Transforming growth factor-ß1 and basic fibroblast growth factor in the injured CNS

1993 • 126 citations

Tacrolimus (FK506) Increases Neuronal Expression of GAP-43 and Improves Functional Recovery after Spinal Cord Injury in Rats

1998 • 125 citations

2,3-Dihydroxy-6-Nitro-7-Sulfamoyl-Benzo(f)Quinoxaline Reduces Glial Loss and Acute White Matter Pathology after Experimental Spinal Cord Contusion

1999 • 122 citations

Basic Fibroblast Growth Factor (bFGF) Enhances Tissue Sparing and Functional Recovery Following Moderate Spinal Cord Injury

1999 • 113 citations

Effects of the Sodium Channel Blocker Tetrodotoxin on Acute White Matter Pathology After Experimental Contusive Spinal Cord Injury

1999 • 110 citations

Delayed Antagonism of AMPA/Kainate Receptors Reduces Long-Term Functional Deficits Resulting from Spinal Cord Trauma

1997 • 108 citations

Altered Acidic and Basic Fibroblast Growth Factor Expression Following Spinal Cord Injury

1993 • 106 citations

Basic and acidic fibroblast growth factors protect spinal motor neurones in vivo after experimental spinal cord injury

1998 • 103 citations

Apoptosis occurs in the oligodendroglial lineage, and is prevented by basic fibroblast growth factor

1995 • 99 citations

Neuronal Apoptosis and Necrosis Following Spinal Cord Ischemia in the Rat

1997 • 97 citations

Neuroprotective effect of MK-801 and U-50488H after contusive spinal cord injury

1989 • 95 citations

Neuroprotective Effects of Basic Fibroblast Growth Factor Following Spinal Cord Contusion Injury in the Rat

1999 • 91 citations

Basic Fibroblast Growth Factor Protects against Excitotoxicity and Chemical Hypoxia in Both Neonatal and Adult Rats

1995 • 89 citations

Increased Basic Fibroblast Growth Factor Expression Following Contusive Spinal Cord Injury

1996 • 88 citations

Posttreatment with Intravenous Basic Fibroblast Growth Factor Reduces Histopathological Damage Following Fluid-Percussion Brain Injury in Rats

1996 • 87 citations

Intermediate filament change in astrocytes following mild cortical contusion

1996 • 85 citations

Internalization and processing of basic fibroblast growth factor by neurons and astrocytes

1991 • 83 citations

Endogenous FGF-2 Is Important for Cholinergic Sprouting in the Denervated Hippocampus

1997 • 81 citations

Genetic influences on cellular reactions to spinal cord injury: Activation of macrophages/microglia and astrocytes is delayed in mice carrying a mutation (WldS) that causes delayed Wallerian degeneration

1996 • 74 citations

Delayed Administration of Basic Fibroblast Growth Factor (bFGF) Attenuates Cognitive Dysfunction Following Parasagittal Fluid Percussion Brain Injury in the Rat

1997 • 73 citations

Basic fibroblast growth factor promotes in vivo cerebral angiogenesis in chronic forebrain ischemia

1991 • 72 citations

Alterations in Fibroblast Growth Factor Receptor Expression Following Brain Injury

1996 • 72 citations

Increased basic fibroblast growth factor mRNA following contusive spinal cord injury

1994 • 66 citations

Intermediate filament change in astrocytes following mild cortical contusion

1996 • 64 citations

Basic fibroblast growth factor down‐regulates myelin basic protein gene expression and alters myelin compaction of mature oligodendrocytes in vitro

1995 • 64 citations

The presence of 4-hydroxynonenal/protein complex as an indicator of oxidative stress after experimental spinal cord contusion in a rat model

1998 • 60 citations

In situ expression of fibroblast growth factor receptors by oligodendrocyte progenitors and oligodendrocytes in adult mouse central nervous system

1997 • 59 citations

The blood-spinal cord barrier after injury: pattern of vascular events proximal and distal to a transection in the rat

1987 • 55 citations

Allografts of CNS tissue possess a blood‐brain barrier: III. Neuropathological, methodological, and immunological considerations

1994 • 54 citations

Dynorphin A-induced rat spinal cord injury: evidence for excitatory amino acid involvement in a pharmacological model of ischemic spinal cord injury.

1994 • 54 citations

GM-1 ganglioside and motor recovery following human spinal cord injury.

1993 • 52 citations

Pharmacological therapy of acute spinal cord injury: studies of high dose methylprednisolone and naloxone.

1988 • 52 citations

Synergistic effect of basic fibroblast growth factor and methylprednisolone on neurological function after experimental spinal cord injury

1995 • 50 citations

Functional Recovery After Central Infusion of α-Melanocyte-Stimulating Hormone in Rats With Spinal Cord Contusion Injury

1999 • 50 citations

Retinoic acid regulates the development of oligodendrocyte precursor cells in vitro

1994 • 47 citations

bFGF and FGFR-3 immunoreactivity in the rat brain following systemic kainic acid administration at convulsant doses: localization of bFGF and FGFR-3 in reactive astrocytes, and FGFR-3 in reactive microglia

1997 • 46 citations

Intraventricular infusion of HBGF-2 promotes cerebral angiogenesis in Wistar rat

1990 • 43 citations

Axonal regeneration by chronically injured supraspinal neurons can be enhanced by exposure to insulin-like growth factor, basic fibroblast growth factor or transforming growth factor beta

1996 • 40 citations

Characterization of the microvascular glycocalyx in normal and injured spinal cord in the rat

1996 • 38 citations

Edema Development and Ion Changes in Rat Spinal Cord After Impact Trauma: Injury Dose–Response Studies

1990 • 38 citations

Single topical application of human recombinant basic fibroblast growth factor (rbfgf) promotes neovascularization in rat cerebral cortex

1993 • 38 citations

FGF‐2 in the MPTP model of parkinson's disease: Effects on astroglial cells

1994 • 36 citations

Delayed administration of basic fibroblast growth factor protects against N-methyl-D-aspartate neurotoxicity in neonatal rats

1993 • 36 citations

Basic fibroblast growth factor improves recovery after chemically induced breakdown of myelin‐like membranes in pure oligodendrocyte cultures

1994 • 30 citations

Effect of the 21-aminosteroid U74006F and methylprednisolone on motor function recovery and oedema after spinal cord compression in rats

2009 • 28 citations

Localization, Differential Expression and Retrograde Axonal Transport Suggest Physiological Role of FGF‐2 in Spinal Autonomic Neurons of the Rat

1997 • 26 citations

Neuroprotective fibroblast growth factor type-2 down-regulates the c-Jun transcription factor in axotomized sympathetic preganglionic neurons of adult rat

1997 • 20 citations