Neuronal Apoptosis and Necrosis Following Spinal Cord Ischemia in the Rat

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

A general method for isolation of high molecular weight DNA from eukaryotes

1976 • 2,827 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Experience with 1509 patients undergoing thoracoabdominal aortic operations

1993 • 1,220 citations

In situ detection of fragmented dna (tunel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note

1995 • 1,171 citations

Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys

1997 • 1,147 citations

Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis

1995 • 834 citations

A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA.

1993 • 823 citations

Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats.

1993 • 703 citations

Very Delayed Infarction after Mild Focal Cerebral Ischemia: A Role for Apoptosis?

1996 • 613 citations

Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models

1995 • 604 citations

A cautionary note on the use of the TUNEL stain to determine apoptosis

1995 • 490 citations

Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain

1993 • 481 citations

Temporal Profile of in situ DNA Fragmentation after Transient Middle Cerebral Artery Occlusion in the Rat

1995 • 477 citations

Morphologic, biochemical, and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia.

1992 • 445 citations

Kainate-induced apoptotic cell death in hippocampal neurons

1994 • 404 citations

Controlled death (apoptosis) of normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters

1984 • 369 citations

Neuronal Necrosis After Middle Cerebral Artery Occlusion in Wistar Rats Progresses at Different Time Intervals in the Caudoputamen and the Cortex

1995 • 349 citations

Apoptosis and Necrosis after Reversible Focal Ischemia: An in Situ DNA Fragmentation Analysis

1996 • 339 citations

Molecular Mechanisms of Developmental Neuronal Death

1993 • 330 citations

Cell Death Induced in a Murine Mastocytoma by 42–47°C Heatingin Vitro: Evidence that the Form of Death Changes from Apoptosis to Necrosis Above a Critical Heat Load

1990 • 316 citations

Detection of DNA fragmentation in apoptosis: application of in situ nick translation to cell culture systems and tissue sections.

1993 • 276 citations

Induction of DNA Fragmentation After 10 to 120 Minutes of Focal Cerebral Ischemia in Rats

1995 • 276 citations

Ultrastructural changes in the hippocampal CA1 region following transient cerebral ischemia: evidence against programmed cell death

1992 • 270 citations

Apoptosis and Expression of Bcl-2 after Compression Trauma to Rat Spinal Cord

1996 • 259 citations

Blockade of glutamate receptors unmasks neuronal apoptosis after oxygen-glucose deprivation in vitro

1995 • 258 citations

Rapid Communication: Regional Variability in DNA Fragmentation After Global Ischemia Evidenced by Combined Histological and Gel Electrophoresis Observations in the Rat Brain

1993 • 235 citations

Apoptosis and necrosis induced in different hippocampal neuron populations by repetitive perforant path stimulation in the rat

1996 • 227 citations

Role of extracellular calcium in anoxic injury of mammalian central white matter.

1990 • 212 citations

Endonuclease activation following focal ischemic injury in the rat brain

1993 • 211 citations

Effects of cycloheximide on delayed neuronal death in rat hippocampus

1990 • 202 citations

DNA damage consistent with apoptosis in transient focal ischaemic neocortex

1994 • 198 citations

Reduction of delayed neuronal death by inhibition of protein synthesis

1990 • 190 citations

Slowly triggered excitotoxicity occurs by necrosis in cortical cultures

1997 • 175 citations

N-methyl-D-aspartate receptors are transiently expressed in the developing spinal cord ventral horn.

1992 • 169 citations

Glutamate‐Induced Neuronal Death Is Not a Programmed Cell Death in Cerebellar Culture

1993 • 160 citations

The mechanism of T cell mediated cytotoxicity II. morphological studies of cell death by time-lapse microcinematography

1976 • 146 citations

Quantitative and qualitative changes in AMPA receptor expression during spinal cord development

1995 • 140 citations

NMDA and Kainate Induce Internucleosomal DNA Cleavage Associated With Both Apoptotic and Necrotic Cell Death in the Neonatal Rat Brain

1995 • 130 citations

Induction and its spread of apoptosis in rat spinal cord after mechanical trauma

1996 • 128 citations

Differences in DNA Fragmentation following Transient Cerebral or Decapitation Ischemia in Rats

1995 • 116 citations

Microcinematographic and electron microscopic analysis of target cell lysis induced by cytotoxic T lymphocytes.

1979 • 111 citations

Transient Spinal Ischemia in Rat: Characterization of Spinal Cord Blood Flow, Extracellular Amino Acid Release, and Concurrent Histopathological Damage

1994 • 97 citations

Cytolysis induced by human lymphotoxin.

1972 • 85 citations

Transient Spinal Ischemia in the Rat: Characterization of Behavioral and Histopathological Consequences as a Function of the Duration of Aortic Occlusion

1994 • 79 citations

Reversal of delayed-onset paraplegia after thoracic aortic surgery with cerebrospinal fluid drainage

1994 • 68 citations

Localisation of glutamate receptor binding sites and mRNAS to the dorsal horn of the rat spinal cord

1993 • 59 citations

Selective Vulnerability of White Matter during Spinal Cord Ischemia

1993 • 51 citations

Spinal cord ischemic injury: is it preventable?

1991 • 37 citations

Temporal pattern of internucleosomal DNA fragmentation in the striatum and hippocampus after transient forebrain ischemia

1995 • 34 citations

Aortic occlusion by a balloon catheter: A method to induce hind limb rigidity in rats

1983 • 22 citations