The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats

A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury

1990 • 2,629 citations

The Pharmacological Basis of Therapeutics

1986 • 2,365 citations

Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids

1980 • 925 citations

A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids.

1980 • 841 citations

Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data

1992 • 716 citations

Central nervous systems trauma and strokeI. Biochemical considerations for oxygen radical formation and lipid peroxidation

1989 • 626 citations

Central nervous system trauma and strokeII. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation

1989 • 580 citations

Recovery of Motor Function after Spinal-Cord Injury — A Randomized, Placebo-Controlled Trial with GM-1 Ganglioside

1991 • 570 citations

Inhibition of phospholipase A2 by "lipocortins" and calpactins. An effect of binding to substrate phospholipids.

1987 • 534 citations

Lipocortin and the mechanism of action of the glucocorticoids

1988 • 499 citations

The neuroprotective pharmacology of methylprednisolone

1992 • 474 citations

Ganglioside Stimulation of Axonal Sprouting in Vitro

1981 • 386 citations

Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex.

1988 • 384 citations

Five distinct calcium and phospholipid binding proteins share homology with lipocortin I.

1988 • 364 citations

Effect of high-dose corticosteroid therapy on blood flow, evoked potentials, and extracellular calcium in experimental spinal injury

1982 • 319 citations

Ganglioside inhibition of glutamate-mediated protein kinase C translocation in primary cultures of cerebellar neurons.

1987 • 309 citations

Gangliosides in the nervous system

1983 • 299 citations

Modulation of protein kinase C and diverse cell functions by sphingosine — a pharmacologically interesting compound linking sphingolipids and signal transduction

1989 • 281 citations

Inflammation near the nerve cell body enhances axonal regeneration

1991 • 279 citations

21-Aminosteroid lipid peroxidation inhibitor U74006F protects against cerebral ischemia in gerbils.

1988 • 266 citations

Characterization of lipocortin I and an immunologically unrelated 33-kDa protein as epidermal growth factor receptor/kinase substrates and phospholipase A2 inhibitors.

1987 • 265 citations

Molecular cloning and expression of the major protein kinase C substrate of platelets

1988 • 250 citations

Effects of intravenous methylprednisolone on spinal cord lipid peroxidation and (Na+ + K+)-ATPase activity

1982 • 249 citations

Regulation of protein kinase C activity by gangliosides.

1987 • 248 citations

Cell regulation by sphingosine and more complex sphingolipids

1991 • 242 citations

Characterization of Ca2+-dependent phospholipid binding and phosphorylation of lipocortin I.

1987 • 236 citations

A pharmacological analysis of the pathophysiological mechanisms of posttraumatic spinal cord ischemia

1986 • 228 citations

Protein kinase C inhibitor proteins

1990 • 213 citations

Lipid Hydrolysis and Peroxidation in Injured Spinal Cord: Partial Protection with Methylprednisolone or Vitamin E and Selenium

1985 • 206 citations

Correlation of methylprednisolone levels in cat spinal cord with its effects on (Na+ + K+)-ATPase, lipid peroxidation, and alpha motor neuron function

1982 • 201 citations

p36, the major cytoplasmic substrate of src tyrosine protein kinase, binds to its p11 regulatory subunit via a short amino-terminal amphiphatic helix.

1988 • 193 citations

Recovery from experimental parkinsonism in primates with GM1 ganglioside treatment

1992 • 187 citations

Further studies on free-radical pathology in the major central nervous system disorders: effect of very high doses of methylprednisolone on the functional outcome, morphology, and chemistry of experimental spinal cord impact injury

1982 • 187 citations

Muscle reinnervation—III. Motoneuron sprouting capacity, enhancement by exogenous gangliosides

1983 • 186 citations

Potassium and calcium changes in injured spinal cords

1986 • 186 citations

Microvascular perfusion and metabolism in injured spinal cord after methylprednisolone treatment

1982 • 181 citations

Effects of the 21-aminosteroid U74006F on posttraumatic spinal cord ischemia in cats

1988 • 176 citations

Calcium/Ganglioside‐Dependent Protein Kinase Activity in Rat Brain Membrane

1985 • 170 citations

Membrane lipid changes in laminectomized and traumatized cat spinal cord.

1985 • 166 citations

Effects of Methylprednisolone and the Combination of α‐Tocopherol and Selenium on Arachidonic Acid Metabolism and Lipid Peroxidation in Traumatized Spinal Cord Tissue

1987 • 166 citations

Recombinant human lipocortin 1 inhibits thromboxane release from guinea-pig isolated perfused lung

1987 • 166 citations

Effects of Brain Gangliosides on Functional Recovery in Experimental Regeneration and Reinnervation

1976 • 159 citations

Regional brain sodium, potassium, and water changes in the rat middle cerebral artery occlusion model of ischemia.

1987 • 153 citations

Alteration of thrornboxane and prostacyclin levels in experimental spinal cord injury

1985 • 148 citations

G _M1 Ganglioside Treatment Facilitates Behavioral Recovery from Bilateral Brain Damage

1984 • 148 citations

Increased phospholipase C activity after experimental brain injury

1982 • 143 citations

Role of Lipid Peroxidation in Post-Traumatic Spinal Cord Degeneration: A Review

1986 • 141 citations

Retrograde changes in the nucleus basalis of the rat, caused by cortical damage, are prevented by exogenous ganglioside GM1

1986 • 132 citations

Glutamate-induced neuronal death in primary cultures of cerebellar granule cells: protection by synthetic derivatives of endogenous sphingolipids.

1990 • 132 citations

Brain Phospholipase A₂ Is Activated After Experimental Closed Head Injury in the Rat

1989 • 130 citations

The 21-aminosteroids: Potent inhibitors of lipid peroxidation for the treatment of central nervous system trauma and ischemia

1989 • 128 citations

Lipocortin inhibition of extracellular and intracellular phospholipases A₂ is substrate concentration dependent

1987 • 115 citations

A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells.

1990 • 115 citations

Spinal Cord Sodium, Potassium, Calcium, and Water Concentration Changes in Rats After Graded Contusion Injury

1989 • 114 citations

Axonal regeneration in dorsal spinal roots is accelerated by peripheral axonal transection

1987 • 108 citations

Inhibition of O2- generation by dexamethasone is mimicked by lipocortin I in alveolar macrophages.

1989 • 108 citations

Chronic GM1 ganglioside treatment reduces dopamine cell body degeneration in the substantia nigra after unilateral hemitransection in rat

1984 • 107 citations

The induction of a regenerative propensity in sensory neurons following peripheral axonal injury

1986 • 105 citations

Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C

1988 • 103 citations

A nonglucocorticoid steroid analog of methylprednisolone duplicates its high-dose pharmacology in models of central nervous system trauma and neuronal membrane damage.

1987 • 98 citations

Plasma atrial natriuretic factor and subarachnoid hemorrhage.

1988 • 98 citations

Gangliosides (GM1 and AGF2) reduce mortality due to ischemia: protection of membrane function.

1987 • 97 citations

Regulation of epidermal growth factor receptor signal transduction. Role of gangliosides.

1990 • 97 citations

Iron-induced lipid peroxidation in spinal cord: Protection with mannitol and methylprednisolone

1985 • 86 citations

Neurite induction in mature cortical neurons in feline GM1-ganglioside storage disease

1977 • 85 citations

Altered levels of PGF in cat spinal cord tissue following traumatic injury

1976 • 84 citations

Hydrocortisone and ‘macrocortin’ inhibit the zymosan-induced release of lyso-PAF from rat peritoneal leucocytes

1985 • 78 citations

Gangliosides inhibit phospholipid‐sensitive Ca²⁺‐dependent kinase phosphorylation of rat myelin basic proteins

1986 • 74 citations

Pretreatment with Alpha Tocopherol Enhances Neurologic Recovery After Experimental Spinal Cord Compression Injury

1988 • 72 citations

Evaluation of the antiinflammatory and phospholipase-inhibitory activity of calpactin II/lipocortin I.

1988 • 66 citations

Human recombinant lipocortin 1 inhibits prostacyclin production by human umbilical artery

1987 • 66 citations

Lipocortin-1 Immunoreactivity in the Normal Human Central Nervous System and Lesions with Astrocytosis

1989 • 65 citations

9‐Amino‐1,2,3,4‐tetrahydroacridine (THA) is a potent blocker of cardiac potassium channels

1987 • 65 citations

Regulation fo protein kinase C activity by various lipids

1988 • 65 citations

Distal cis-acting promoter sequences mediate glucocorticoid stimulation of cardiac atrial natriuretic factor gene transcription.

1991 • 64 citations

The multimolecular cascade of spinal cord injury

1987 • 63 citations

Methylprednisolone in Spinal Cord Injury: The Possible Mechanism of Action

1990 • 58 citations

A study of serum antidiuretic hormone and atrial natriuretic peptide levels in a series of patients with intracranial disease and hyponatremia

1989 • 57 citations

Effect of methylprednisolone on motor function and spinal cord blood flow after spinal cord compression in rats

2009 • 55 citations

Ganglioside-modulated protein phosphorylation. Partial purification and characterization of a ganglioside-inhibited protein kinase in brain.

1988 • 54 citations

Regulation of Ca²⁺/Calmodulin‐Dependent Protein Kinase II by Brain Gangliosides

1990 • 53 citations

Steroid suppression of axon sprouting in the hippocampal dentate gyrus of the adult rat: Dose-response relationship

1983 • 53 citations

Acute enhancement of spinal cord synaptosomal (Na+ + K+)-ATPase activity in cats following intravenous methylprednisolone

1981 • 52 citations

Suprasellar and intraventricular blood predict elevated plasma atrial natriuretic factor in subarachnoid hemorrhage.

1991 • 47 citations

The Effect of Dexamethasone on L- -Lysophosphatidyl Choline (Lysolecithin)-Induced Demyelination of the Rat Spinal Cord

1986 • 44 citations

Behavioral Endpoint Measures for Preclinical Trials Using Experimental Models of Spinal Cord Injury

1992 • 40 citations

Studies of experimental cervical spinal cord transection

1979 • 39 citations

Gangliosides Prevent Ischemia‐Induced Down‐Regulation of Protein Kinase C in Fetal Rat Brain

1990 • 37 citations

Evidence for a role of phospholipase activity in the serum stimulation of Na+ influx in human fibroblasts.

1984 • 36 citations

Effects of BW755C, a mixed cyclo-oxygenase-lipoxygenase inhibitor, following traumatic spinal cord injury in rats

1988 • 35 citations

Phosphorylation of lipocortin-1 by the epidermal growth factor receptor

1991 • 35 citations

The Degradation of Phospholipids, Formation of Metabolites of Arachidonic Acid, and Demyelination Following Experimental Spinal Cord Injury

1985 • 35 citations

Altered regulation of lesion-induced synaptogenesis by adrenalectomy and corticosterone in young adult rats

1986 • 34 citations

Effects of dexamethasone on late radiation injury following partial-body and local organ exposures.

1992 • 33 citations

Beneficial Effects of Acute Intravenous Ibuprofen on Neurologic Recovery of Head-Injured Mice: Comparison of Cyclooxygenase Inhibition with Inhibition of Thromboxane A₂ Synthetase or 5-Lipoxygenase

1985 • 32 citations

The effect of GM1 ganglioside on coerulospinal, noradrenergic, adult neurons and on fetal monoaminergic neurons transplanted into the transected spinal cord of the adult rat

1986 • 32 citations

Stimulation of a Ca(2+)-dependent protein kinase by GM1 ganglioside in nerve growth factor-treated PC12 cells.

1991 • 31 citations

Exogenous GM1 gangliosides protect against retrograde degeneration following posterior neocortex lesions in developing hamsters

1988 • 30 citations

Increased thromboxane A2 and 5-HETE production following spinal cord ischemia in the rabbit

1987 • 28 citations

Effects of Dexamethasone on Late Radiation Injury Following Partial-Body and Local Organ Exposures

1992 • 27 citations

Molecular mechanisms of homologous desensitization and internalization of muscarinic receptors in primary cultures of neonatal corticostriatal neurons.

1990 • 26 citations

Forskolin-Induced Immunoreactive Atrial Natriuretic Peptide (ANP) Secretion and Pro-ANP Messenger Ribonucleic Acid Expression of Hypothalamic Neurons in Culture: Modulation by Glucocorticoids*

1991 • 26 citations

Tissue Na, K, and Ca Changes in Regional Cerebral Ischemia: Their Measurement and Interpretation

1986 • 24 citations

Functional recovery from spinal cord trauma following dexamethazone and chlorpromazine therapy in dogs

1976 • 21 citations

A role of GABAA receptors in hypoxia-induced conduction failure of neonatal rat spinal dorsal column axons

1993 • 20 citations

Lipocortins are major substrates for protein kinase C in extracts of human neutrophils.

1990 • 19 citations

GABA and potassium effects on corticospinal and primary afferent tracts of neonatal rat spinal dorsal columns

1993 • 19 citations

Experimental neoplastic spinal cord compression: effect of anti-inflammatory agents and glutamate receptor antagonists on vascular permeability.

1990 • 19 citations

Atrial natriuretic peptide-LI following subarachnoid haemorrhage in man

1990 • 18 citations

Elevation and clearance of extracellular K+ following contusion of the rat spinal cord

1991 • 18 citations

Neurite outgrowth in dorsal root neuronal hybrid clones modulated by ganglioside GM1 and disintegrins

1991 • 18 citations

Ganglioside GM1 prevents death induced by excessive excitatory neurotransmission in cultured hippocampal pyramidal neurons

1991 • 17 citations

Adrenalectomy and dexamethasone administration: effect on atrial natriuretic peptide synthesis and circulating forms

1991 • 17 citations

A role of lyso-phosphatidylcholine in GM3-dependent inhibition of epidermal growth factor receptor autophosphorylation in A431 plasma membranes

1990 • 16 citations

Experimental Neoplastic Spinal Cord Compression; Effect of Anti-Inflammatory Agents and Glutamate Receptor Antagonists on Vascular Permeability

1990 • 16 citations

Cerebrospinal fluid atrial natriuretic factor in intracranial disease.

1990 • 15 citations

Gangliosides prevent the inhibition by K-252a of NGF responses in PC12 cells

1992 • 15 citations

Simultaneous phosphorylation of three human calpactins by kinase C

1991 • 13 citations

Effect of Brain Gangliosides on Early and Late Consequences of a Transient Incomplete Forebrain Ischemia in the Rat

1989 • 13 citations

Comparison of Soluble Dexamethasone Sodium Phosphate with Free Dexamethasone and Indomethacin in Treatment of Experimental Neoplastic Spinal Cord Compression

1988 • 12 citations

Phosphorylation of myelin basic protein and peptides by ganglioside-stimulated protein kinase

1989 • 8 citations

Effect of protein kinase modulators on the induction of morphological differentiation of pheochromocytoma PC12 cells by nerve and fibroblast growth factors

1990 • 8 citations

Adrenal cortex contributes to the regulation of NaCl-stimulated ANP release in the rat

1990 • 7 citations

Evaluation of a low dose administration of aspirin, dipyridamol and steroid. Therapeutic effects on motor function and protective effects on Na +-K +-activated ATPase activity against lipid peroxidation in an experimental model of spinal cord injury

1985 • 5 citations

Phorbol ester receptors in cerebral cortex of cats with GM1 gangliosidosis

1991 • 2 citations

Glucocorticoids and head injury

1987 • 1 citations