Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1984 • 2,884 citations

A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury

1990 • 2,629 citations

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

1986 • 2,428 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

The physiology of excitatory amino acids in the vertebrate central nervous system

1987 • 1,718 citations

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1984 • 1,689 citations

Calcium Dependence of Toxic Cell Death: A Final Common Pathway

1979 • 1,478 citations

Cerebral ischemia. II. The no-reflow phenomenon.

1968 • 1,346 citations

Cerebral Arterial Spasm – A Controlled Trial of Nimodipine in Patients with Subarachnoid Hemorrhage

1983 • 1,148 citations

Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial.

1989 • 1,087 citations

SURGERY OF EXPERIMENTAL LESION OF SPINAL CORD EQUIVALENT TO CRUSH INJURY OF FRACTURE DISLOCATION OF SPINAL COLUMN

1911 • 726 citations

Calcium and Ischemic Injury

1986 • 529 citations

Nimodipine treatment in poor-grade aneurysm patients

1988 • 527 citations

Novel 21-amino steroids as potent inhibitors of iron-dependent lipid peroxidation.

1987 • 474 citations

A potential role for excitotoxins in the pathophysiology of spinal cord injury

1988 • 377 citations

Nimodipine Improves Cerebral Blood Flow and Neurologic Recovery after Complete Cerebral Ischemia in the Dog

1983 • 347 citations

Cellular morphology of chronic spinal cord injury in the cat: Analysis of myelinated axons by line-sampling

1983 • 338 citations

Incidence of traumatic spinal cord lesions

1975 • 326 citations

Effect of high-dose corticosteroid therapy on blood flow, evoked potentials, and extracellular calcium in experimental spinal injury

1982 • 319 citations

Selective neuron loss after cerebral ischemia in the rat: Possible role of transmitter glutamate

2009 • 305 citations

Pathological findings in acute experimental spinal cord trauma

1971 • 281 citations

EFFECTS OF CALCIUM ION CONCENTRATION ON THE DEGENERATION OF AMPUTATED AXONS IN TISSUE CULTURE

1973 • 257 citations

Neurochemical Correlates to Selective Neuronal Vulnerability

1985 • 252 citations

REMARKS ON THE HISTOPATHOLOGICAL CHANGES IN THE SPINAL CORD DUE TO IMPACT. AN EXPERIMENTAL STUDY

1914 • 240 citations

The relationships among the severity of spinal cord injury, motor and somatosensory evoked potentials and spinal cord blood flow

1989 • 237 citations

A pharmacological analysis of the pathophysiological mechanisms of posttraumatic spinal cord ischemia

1986 • 228 citations

Experimental Treatments of Acute Spinal Cord Injury

1969 • 220 citations

Endorphins in experimental spinal injury: Therapeutic effect of naloxone

1981 • 214 citations

Restoration of Middle Cerebral Artery Flow in Experimental Infarction

1969 • 212 citations

Altered norepinephrine metabolism following experimental spinal cord injury

1972 • 209 citations

Calcium-induced degeneration of axoplasm in isolated segments of rat peripheral nerve

1974 • 209 citations

Lipid Hydrolysis and Peroxidation in Injured Spinal Cord: Partial Protection with Methylprednisolone or Vitamin E and Selenium

1985 • 206 citations

Pathology of experimental spinal cord trauma. II. Ultrastructure of axons and myelin.

1978 • 205 citations

Effect of naloxone on posttraumatic ischemia in experimental spinal contusion

1981 • 202 citations

Review of the effect of spinal cord trauma on the vessels and blood flow in the spinal cord

1976 • 201 citations

Ca2+-accumulation in experimental spinal cord trauma

1981 • 199 citations

Effect of acute spinal cord compression injury on regional spinal cord blood flow in primates

1976 • 197 citations

Extracellular calcium activity in the injured spinal cord

1983 • 196 citations

Effects of a single large dose of methylprednisolone sodium succinate on experimental posttraumatic spinal cord ischemia

1984 • 193 citations

Extracellular calcium ionic activity in experimental spinal cord contusion

1982 • 193 citations

Potassium and calcium changes in injured spinal cords

1986 • 186 citations

Spinal cord injury. Review of basic and applied research.

1981 • 186 citations

Regional spinal cord blood flow in rats after severe cord trauma

1978 • 185 citations

Characterization of the calcium-induced disruption of neurofilaments in rat peripheral nerve

1979 • 183 citations

Microvascular perfusion and metabolism in injured spinal cord after methylprednisolone treatment

1982 • 181 citations

Effects of the 21-aminosteroid U74006F on posttraumatic spinal cord ischemia in cats

1988 • 176 citations

An electron-microscopic analysis of axonal alterations following blunt contusion of the spinal cord of the rhesus monkey (Macaca mulatta)

1978 • 171 citations

Effect of the Calcium Antagonist, Nimodipine, on Cerebral Blood Flow and Metabolism in the Primate

1981 • 167 citations

The effect of nimodipine and dextran on axonal function and blood flow following experimental spinal cord injury

1989 • 160 citations

Pathology of Spinal Injuries

1984 • 156 citations

Microangiographic study of experimental spinal cord injuries

1971 • 146 citations

The therapeutic value of nimodipine in experimental focal cerebral ischemia

1987 • 146 citations

Reassessment of cerebral capillary changes in acute global ischemia and their relationship to the "no-reflow phenomenon".

1977 • 143 citations

Loss of autoregulation and posttraumatic ischemia following experimental spinal cord trauma

1979 • 143 citations

Spinal cord blood flow and systemic blood pressure after experimental spinal cord injury in rats.

1989 • 141 citations

The effect of spinal distraction on regional spinal cord blood flow in cats

1980 • 137 citations

The microvasculature in transitory traumatic paraplegia

1971 • 137 citations

Cellular mechanisms underlying excitotoxicity

1987 • 137 citations

Local spinal cord blood flow in experimental traumatic myelopathy

1975 • 133 citations

Altered blood flow and secondary injury in experimental spinal cord trauma

1978 • 132 citations

Reversible spinal cord trauma in cats

1972 • 131 citations

Nimodipine, a New Calcium Antagonist, in the Prophylactic Treatment of Migraine

1983 • 127 citations

A neuroanatomical analysis of spinal cord injury in the rhesus monkey (Macaca mulatta)

1976 • 123 citations

Experimental spinal cord injury: treatment with naloxone.

1982 • 122 citations

Correlation Between Attenuation of Posttraumatic Spinal Cord Ischemia and Preservation of Tissue Vitamin E by the 21-Aminosteroid U74006F: Evidence for anIn VivoAntioxidant Mechanism

1989 • 120 citations

Excitatory amino acids and anoxic/ischaemic brain damage

1985 • 118 citations

Spinal cord blood flow after acute experimental cord injury in dogs

1976 • 116 citations

Spinal Cord Sodium, Potassium, Calcium, and Water Concentration Changes in Rats After Graded Contusion Injury

1989 • 114 citations

Altered norepinephrine metabolism following experimental spinal cord injury

1972 • 114 citations

Blood flow in normal and injured monkey spinal cord

1975 • 111 citations

Hypervolemic hemodilution in experimental focal cerebral ischemia

1983 • 110 citations

Eicosanoids in the central nervous system

1985 • 104 citations

Nerve fibres in spinal cord impact injuries

1983 • 102 citations

Acute Spinal Cord Injury in the Rat: Comparison of Three Experimental Techniques

1983 • 96 citations

Spinal cord blood flow as affected by changes in systemic arterial blood pressure

1976 • 96 citations

Chronic regenerative changes in the spinal cord after cord compression injury in rats

1987 • 95 citations

Spine-Spinal Cord Relationships in Spinal Cord Trauma

1983 • 94 citations

Comparison of early and late naloxone treatment in experimental spinal injury

1982 • 91 citations

Microangiographic observations of the experimentally traumatized spinal cord

1971 • 87 citations

Management of acute spinal cord injuries.

1984 • 87 citations

Prevention of symptomatic vasospasm by topically applied Nimodipine

1982 • 85 citations

Effect of the Calcium Antagonist Nimodipine on Local Cerebral Blood Flow: Relationship to Arterial Blood Pressure

1984 • 85 citations

A review and update of experiment and clinical studies of spinal cord injury

1983 • 84 citations

Effect of trauma dose on spinal cord edema

1981 • 82 citations

Relationship between Posttraumatic Ischemia and Hemorrhage in the Injured Rat Spinal Cord as Shown by Colloidal Carbon Angiography

1986 • 79 citations

Interaction of Lipid Peroxidation and Calcium in the Pathogenesis of Neuronal Injury

1985 • 75 citations

Evaluation of the calcium channel antagonist nimodipine in experimental spinal cord ischemia

1984 • 74 citations

Effect of a calcium channel blocker on posttraumatic spinal cord blood flow

1987 • 73 citations

The role of calcium and cellular membrane dysfunction in experimental trauma and subarachnoid hemorrhage

1985 • 72 citations

Acute Cardiovascular Effects of Experimental Spinal Cord Injury

1988 • 72 citations

Excitatory amino acid receptors and ischemic brain damage in the rat

1987 • 68 citations

The Post-Injury Responses in Trauma and Ischemia: Secondary Injury or Protective Mechanisms?

1987 • 66 citations

Spinal cord blood flow in dogs: the effect of blood pressure

1973 • 66 citations

Comparison of crystalloids and colloids for hemodilution in a model of focal cerebral ischemia

1990 • 62 citations

Spinal cord blood flow in dogs : 2. The effect of the blood gases

1973 • 61 citations

Current concepts in the immediate management of acute spinal cord injuries.

1979 • 59 citations

The effects of ischemia on long-tract neural conduction in the spinal cord

1979 • 58 citations

Functional analysis of an electromechanical spinal cord injury device

1987 • 57 citations

Spinal cord energy metabolism in normal and postlaminectomy cats

1980 • 57 citations

Improvement in Post-traumatic Spinal Cord Blood Flow with a Combination of a Calcium Channel Blocker and a Vasopressor

1989 • 57 citations

The effect of blood transfusion, dopamine, and gamma hydroxybutyrate on posttraumatic ischemia of the spinal cord

1982 • 54 citations

Effect of nimodipine on cerebral functional and metabolic recovery following ischemia in the rat brain.

1986 • 53 citations

Reversal of cerebral arterial spasm by intrathecal administration of a calcium antagonist (nimodipine)

1984 • 52 citations

Effect of TRH analogs on neurologic recovery after experimental spinal trauma

1985 • 52 citations

Acute spinal cord injury: analysis of epidemiologic factors.

1979 • 52 citations

Blood Pressure Responses in Acute Compression of the Spinal Cord

1964 • 50 citations

Increase in rat spinal cord blood flow with the calcium channel blocker, nimodipine

1985 • 46 citations

Morphological evidence of microcirculatory disturbances in experimental spinal cord trauma.

1978 • 45 citations

Effect of sympathectomy on spinal blood flow autoregulation and posttraumatic ischemia

1982 • 44 citations

Norepinephrine levels in experimental spinal cord trauma

1977 • 41 citations

Failure of Nimodipine to Reverse Acute Experimental Spinal Cord Injury

1985 • 40 citations

Spinal cord injury in rats: inability of nimodipine or anti-neutrophil serum to improve spinal cord blood flow or neurologic status

1989 • 40 citations

Concentrations of Putative Neurovascular Transmitters in Major Cerebral Arteries and Small Pial Vessels of Various Species

1987 • 39 citations

The histopathology of experimental spinal cord trauma

1978 • 39 citations

Spinal Cord Blood Flow Measured with Microspheres Following Spinal Cord Injury in the Rat

1986 • 38 citations

Naloxone and Experimental Spinal Cord Injury: Part 2

1986 • 33 citations

Successful Improvement of Blood Pressure, Cardiac Output, and Spinal Cord Blood Flow after Experimental Spinal Cord Injury

1987 • 32 citations

Pressor response resulting from experimental contusion injury to the spinal cord

1979 • 32 citations

Calcium Antagonists, Cerebral Ischemia and Vasospasm

1984 • 32 citations

Failure of Blood Transfusion or Naloxone to Improve Clinical Recovery after Experimental Spinal Cord Injury

1986 • 31 citations

Spinal Cord Dysfunction: Assessment

1989 • 29 citations

Naloxone and Experimental Spinal Cord Injury: Part 1

1986 • 28 citations

Failure of Naloxone to Improve Spinal Cord Blood Flow and Cardiac Output after Spinal Cord Injury

1986 • 26 citations

Effect of Naloxone in Experimental Acute Spinal Cord Injury

1987 • 25 citations

Experimental spinal cord injury

1988 • 22 citations

The Effect of Nimodipine on Post-ischemic Cerebral Glucose Utilization and Blood Flow in the Rat

1987 • 22 citations

Hemorrhagic Changes in Experimental Spinal Cord Injury Models

1985 • 21 citations

Acute occlusion of the posterior spinal vein

1979 • 20 citations

Changes in Myelin and Axonal Proteins in CaCl₂-Induced Myelopathy in Rat Spinal Cord

1984 • 20 citations

A microcomputer system for on-line collection of blood flow and related physiological data

1987 • 18 citations

Computer graphics analysis of stresses in blood flow through a prosthetic heart valve

1975 • 18 citations

Experimental Spinal Cord Injury

1972 • 18 citations

Effect of regional spinal cord blood flow and central control in recovery from spinal cord injury

1989 • 17 citations

Mitochondrial O2 use and ATP synthesis: Kinetic effects of Ca++ and HPO4−2 modulated by glucocorticoids

1980 • 16 citations

Acute management of spinal cord injury

1990 • 16 citations

The treatment of hypotension due to acute experimental spinal cord compression injury.

1980 • 16 citations

Molecular and Anatomical Correlates of Spinal Cord Injury

1985 • 14 citations

Studies of experimental cervical spinal cord transection

1980 • 12 citations

Influence of Arterial Blood Pressure upon Central Hemorrhagic Necrosis after Severe Spinal Cord Injury

1979 • 11 citations

Calcium-Activated Mediators of Secondary Injury in the Spinal Cord

1986 • 11 citations