Cell Death Regulation in Drosophila

Caspases: Enemies Within

1998 • 6,923 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Programmed Cell Death in Animal Development

1997 • 2,690 citations

IAP family proteins---suppressors of apoptosis

1999 • 2,570 citations

Biochemical Pathways of Caspase Activation During Apoptosis

1999 • 2,567 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Genetic Control of Programmed Cell Death in Drosophila

1994 • 1,028 citations

Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

1996 • 1,027 citations

Apoptotic DNA Fragmentation

2000 • 885 citations

Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death

1995 • 728 citations

The head involution defective gene of Drosophila melanogaster functions in programmed cell death.

1995 • 685 citations

Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?

1999 • 659 citations

A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors.

1996 • 637 citations

Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.

1996 • 515 citations

The Drosophila Caspase Inhibitor DIAP1 Is Essential for Cell Survival and Is Negatively Regulated by HID

1999 • 499 citations

Ubiquitination: RING for destruction?

2000 • 496 citations

Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function

2000 • 448 citations

Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation

1999 • 418 citations

grim, a novel cell death gene in Drosophila.

1996 • 414 citations

An exegesis of IAPs: salvation and surprises from BIR motifs

1999 • 345 citations

Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway

1999 • 329 citations

CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis

1997 • 316 citations

CIDE, a novel family of cell death activators with homology to the 45kDa subunit of the DNA fragmentation factor

1998 • 315 citations

DCP-1, a Drosophila Cell Death Protease Essential for Development

1997 • 312 citations

DRONC, an ecdysone-inducible Drosophila caspase

1999 • 276 citations

Control of the Cell Death Pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-Related Caspase Activator

1999 • 242 citations

The Drosophila caspase DRONC is a glutamate/aspartate protease whose activity is regulated by DIAP1, HID and GRIM

2000 • 226 citations

Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis

1999 • 222 citations

Dredd,a Novel Effector of the Apoptosis ActivatorsReaper, Grim,andHidinDrosophila

1998 • 218 citations

Inhibition of Reaper-induced apoptosis by interaction with inhibitor of apoptosis proteins (IAPs)

1997 • 210 citations

Conservation of baculovirus inhibitor of apoptosis repeat proteins (BIRPs) in viruses, nematodes, vertebrates and yeasts

1998 • 204 citations

Inhibitor of Apoptosis Proteins Physically Interact with and Block Apoptosis Induced by Drosophila Proteins HID and GRIM

1998 • 203 citations

HAC-1, a Drosophila Homolog of APAF-1 and CED-4, Functions in Developmental and Radiation-Induced Apoptosis

1999 • 203 citations

Identification of a Drosophila melanogaster ICE/CED-3-related protease, drICE

1997 • 198 citations

Diverse Domains of THREAD/DIAP1 Are Required to Inhibit Apoptosis Induced by REAPER and HID in Drosophila

2000 • 197 citations

Role for yeast inhibitor of apoptosis (IAP)-like proteins in cell division

1999 • 194 citations

An auxiliary mode of apoptotic DNA fragmentation provided by phagocytes

2000 • 191 citations

NUC-1, aCaenorhabditis elegansDNase II homolog, functions in an intermediate step of DNA degradation during apoptosis

2000 • 174 citations

Debcl, a Proapoptotic Bcl-2 Homologue, Is a Component of the Drosophila melanogaster Cell Death Machinery

2000 • 168 citations

Drob-1, a Drosophila member of the Bcl-2/CED-9 family that promotes cell death

2000 • 157 citations

An emerging blueprint for apoptosis in Drosophila

1999 • 151 citations

The modular nature of apoptotic signaling proteins

1999 • 150 citations

Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo

2000 • 139 citations

The Drosophila Bcl-2 family member dBorg-1 functions in the apoptotic response to UV-irradiation

2000 • 125 citations

DECAY, a Novel Drosophila Caspase Related to Mammalian Caspase-3 and Caspase-7

1999 • 123 citations

Altered Cytochrome c Display Precedes Apoptotic Cell Death in Drosophila

1999 • 123 citations

Apaf1 and the apoptotic machinery

1999 • 119 citations

Solution Structure of the CIDE-N Domain of CIDE-B and a Model for CIDE-N/CIDE-N Interactions in the DNA Fragmentation Pathway of Apoptosis

1999 • 104 citations

Prodomains – adaptors – oligomerization: the pursuit of caspase activation in apoptosis

1999 • 103 citations

Divinations and Surprises: Genetic Analysis of Caspase Function in Mice

2000 • 101 citations

Deterin, a New Inhibitor of Apoptosis from Drosophila melanogaster

2000 • 96 citations

Drosophila pro-apoptotic Bcl-2/Bax homologue reveals evolutionary conservation of cell death mechanisms.

2000 • 93 citations

Identification of Multiple Caenorhabditis elegansCaspases and Their Potential Roles in Proteolytic Cascades

1998 • 89 citations

Reaper-induced dissociation of a Scythe-sequestered cytochrome c-releasing activity

1999 • 85 citations

A Novel Activation Mechanism of Caspase-activated DNase fromDrosophila melanogaster

2000 • 54 citations