Novel protein kinase C isoforms and mitogen-activated kinase kinase mediate phorbol ester-induced osteopontin expression

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

1998 • 3,026 citations

Protein kinase C and lipid signaling for sustained cellular responses

1995 • 2,527 citations

Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976

1993 • 1,589 citations

Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.

1990 • 1,507 citations

Rottlerin, a Novel Protein Kinase Inhibitor

1994 • 839 citations

Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity.

1993 • 546 citations

Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C

1993 • 523 citations

Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion

1999 • 387 citations

The Family of Protein Kinase C for Signal Transduction

1989 • 383 citations

Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells.

1994 • 377 citations

Tumour promoter induces anchorage independence irreversibly

1979 • 285 citations

Effect of phorbol esters on protein kinase C-zeta.

1992 • 282 citations

Protein kinase Cδ

1999 • 243 citations

Osteopontin, a transformation-associated cell adhesion phosphoprotein, is induced by 12-O-tetradecanoylphorbol 13-acetate in mouse epidermis

1989 • 238 citations

The epsilon isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts.

1993 • 222 citations

The murine gene encoding secreted phosphoprotein 1 (osteopontin): promoter structure, activity, and induction in vivo by estrogen and progesterone

1991 • 169 citations

Transgenic mice overexpressing protein kinase Cdelta in the epidermis are resistant to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.

1999 • 154 citations

Molecular cloning of a tumor promoter‐inducible mRNA found in JB6 mouse epidermal cells: Induction is stable at high, but not at low, cell densities

1987 • 132 citations

Secreted phosphoprotein mrna is induced during multi‐stage carcinogenesis in mouse skin and correlates with the metastatic potential of murine fibroblasts

1990 • 118 citations

Application of phorbol ester to mouse skin causes a rapid and sustained loss of protein kinase C

1987 • 117 citations

The Albert Lasker Medical Awards. The family of protein kinase C for signal transduction

1989 • 111 citations

Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion.

2000 • 99 citations

Overexpression of protein kinase C epsilon is oncogenic in rat colonic epithelial cells.

1996 • 99 citations

Osteopontin is required for full expression of the transformed phenotype by the ras oncogene

2000 • 93 citations

Cross‐talk between epidermal growth factor receptor and protein kinase C during calcium‐induced differentiation of keratinocytes

2000 • 54 citations

1 alpha,25-dihydroxyvitamin D3 stimulates synthesis and secretion of nonphosphorylated osteopontin (secreted phosphoprotein 1) in mouse JB6 epidermal cells.

1991 • 51 citations

A cell culture assay for tumor‐promoter‐dependent progression toward neoplastic phenotype: Detection of tumor promoters and promotion inhibitors

1981 • 50 citations

Phosphorylation of elongation factor 2: a key mechanism regulating gene expression in vertebrates.

1990 • 41 citations

Elevated expression of secondary, but not early, responding genes to phorbol ester tumor promoters in papillomas and carcinomas of mouse skin

1990 • 38 citations

1 alpha,25-Dihydroxyvitamin D3 enhances 12-O-tetradecanoylphorbol-13-acetate- induced tumorigenic transformation and osteopontin expression in mouse JB6 epidermal cells.

1993 • 33 citations

Calcitriol regulation of osteopontin expression in mouse epidermal cells.

1994 • 32 citations

Protein kinase C and skin tumor promotion

1995 • 29 citations

Stimulation of Osteopontin mRNA Expression in HL-60 Cells Is Independent of Differentiation

1997 • 27 citations

Evidence for two pathways of protein kinase C induction of 2AR expression: Correlation with mitogenesis

1989 • 23 citations

TPA-mediated regulation of osteopontin in human malignant glioma cells.

1998 • 19 citations

Transforming JB6 cells exhibit enhanced integrin-mediated adhesion to osteopontin

2000 • 18 citations

Four-day duration of tumor promoter exposure required to transform JB6 promotion-sensitive cells to anchorage independence.

1988 • 14 citations

Calcitriol regulation of osteopontin expression in mouse epidermal cells

1994 • 10 citations

Promotion-resistant JB6 mouse epidermal cells exhibit defects in phosphatidylethanolamine synthesis and phorbol ester-induced phosphatidylcholine hydrolysis

1997 • 5 citations