Expression, roles, receptors, and regulation of osteopontin in the kidney

New Perspectives in Cell Adhesion: RGD and Integrins

1987 • 4,835 citations

Eta-1 (Osteopontin): An Early Component of Type-1 (Cell-Mediated) Immunity

2000 • 1,104 citations

Osteopontin: a protein with diverse functions

1993 • 1,082 citations

Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence.

1986 • 1,078 citations

CD44: Structure, Function and Association with the Malignant Process

1997 • 1,004 citations

Receptor-Ligand Interaction Between CD44 and Osteopontin (Eta-1)

1996 • 930 citations

The Nature and Significance of Osteopontin

1989 • 561 citations

Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization

1988 • 519 citations

The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro.

1995 • 508 citations

Phosphate is a specific signal for induction of osteopontin gene expression

2000 • 507 citations

NF-κB Mediates αvβ3 Integrin-induced Endothelial Cell Survival

1998 • 484 citations

Expression and distribution of osteopontin in human tissues: widespread association with luminal epithelial surfaces.

1992 • 459 citations

Expression and modulation of CD44 variant isoforms in humans

1994 • 436 citations

Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamily.

1992 • 394 citations

Renal expression of genes that promote interstitial inflammation and fibrosis in rats with protein-overload proteinuria

1995 • 364 citations

Osteopontin expression and distribution in human carcinomas.

1994 • 331 citations

Obstructive uropathy in the mouse: Role of osteopontin in interstitial fibrosis and apoptosis

1999 • 286 citations

Pathogenesis of cyclosporine nephropathy

1995 • 250 citations

Osteopontin N-terminal Domain Contains a Cryptic Adhesive Sequence Recognized by α9β1 Integrin

1996 • 246 citations

In progressive nephropathies, overload of tubular cells with filtered proteins translates glomerular permeability dysfunction into cellular signals of interstitial inflammation.

1998 • 242 citations

Osteopontin expression in angiotensin II-induced tubulointerstitial nephritis

1994 • 228 citations

Structure and expression of the mRNA encoding urinary stone protein (osteopontin)

1993 • 228 citations

Definition of a specific interaction between the early T lymphocyte activation 1 (Eta-1) protein and murine macrophages in vitro and its effect upon macrophages in vivo.

1990 • 228 citations

Osteopontin is a ligand for the α4β1 integrin

1998 • 214 citations

Adhesive properties of osteopontin: regulation by a naturally occurring thrombin-cleavage in close proximity to the GRGDS cell-binding domain.

1994 • 209 citations

Molecular cloning and characterization of 2B7, a rat mRNA which distinguishes smooth muscle cell phenotypes and is identical to osteopontin (secreted phosphoprotein I, 2aR)

1991 • 191 citations

Control of calcium oxalate crystal structure and cell adherence by urinary macromolecules

1998 • 189 citations

Osteopontin Expression in Cardiovascular Diseases^a

1995 • 187 citations

Osteopontin: An Interfacial Extracellular Matrix Protein in Mineralized Tissues

1996 • 179 citations

Osteopontin inhibits induction of nitric oxide synthase gene expression by inflammatory mediators in mouse kidney epithelial cells.

1994 • 178 citations

Osteopontin Function in Pathology: Lessons from Osteopontin-Deficient Mice

1999 • 175 citations

Cellular proliferation and macrophage influx precede interstitial fibrosis in cyclosporine nephrotoxicity

1995 • 174 citations

Adhesion of calcium oxalate monohydrate crystals to renal epithelial cells is inhibited by specific anions

1995 • 171 citations

Tubulointerstitial disease in glomerulonephritis. Potential role of osteopontin (uropontin).

1994 • 163 citations

Osteopontin and β ₃ Integrin Are Coordinately Expressed in Regenerating Endothelium In Vivo and Stimulate Arg-Gly-Asp–Dependent Endothelial Migration In Vitro

1995 • 162 citations

The immunology of Eta-1/osteopontin

1996 • 147 citations

Overexpression of chemokines, fibrogenic cytokines, and myofibroblasts in human membranous nephropathy

2000 • 142 citations

CD44 variant isoforms are preferentially expressed in basal epithelia of non-malignant human fetal and adult tissues

1994 • 138 citations

Osteopontin inhibits nitric oxide production and cytotoxicity by activated RAW264.7 macrophages

1996 • 133 citations

The calcium oxalate crystal growth inhibitor protein produced by mouse kidney cortical cells in culture is osteopontin

1992 • 123 citations

Contribution of human uropontin to inhibition of calcium oxalate crystallization

1998 • 123 citations

Osteopontin Expression in Fetal and Mature Human Kidney

1999 • 122 citations

Physiological properties and differential glycosylation of phosphorylated and nonphosphorylated forms of osteopontin secreted by normal rat kidney cells.

1990 • 116 citations

44-kDal bone phosphoprotein (osteopontin) antigenicity at ectopic sites in newborn rats: kidney and nervous tissues

1988 • 116 citations

Interstitial inflammation and fibrosis in rats with diet-induced hypercholesterolemia

1996 • 110 citations

Osteopontin‐Induced Modifications of Cellular Functions^a

1995 • 109 citations

Molecular cloning and sequencing of cDNA encoding urinary stone protein, which is identical to osteopontin

1992 • 105 citations

Renal Injury and Salt-Sensitive Hypertension After Exposure to Catecholamines

1999 • 99 citations

Early and persistent up-regulated expression of renal cortical osteopontin in experimental hydronephrosis.

1995 • 99 citations

Expression of CD44 in kidney after acute ischemic injury in rats

2000 • 95 citations

Renal cell osteopontin production is stimulated by calcium oxalate monohydrate crystals

1997 • 94 citations

Upregulated renal tubular CD44, hyaluronan, and osteopontin in kdkd mice with interstitial nephritis

1997 • 93 citations

Reduced tolerance to acute renal ischemia in mice with a targeted disruption of the osteopontin gene

1999 • 93 citations

Osteopontin expression in progressive renal injury in remnant kidney: Role of angiotensin II

2000 • 90 citations

A functional role for osteopontin in experimental crescentic glomerulonephritis in the rat.

1998 • 87 citations

Expression of osteopontin, a urinary inhibitor of stone mineral crystal growth, in rat kidney

1995 • 86 citations

IL-1 Up-Regulates Osteopontin Expression in Experimental Crescentic Glomerulonephritis in the Rat

1999 • 85 citations

Expression of osteopontin in gentamicin-induced acute tubular necrosis and its recovery process

2001 • 83 citations

The Activation State of αvβ3Regulates Platelet and Lymphocyte Adhesion to Intact and Thrombin-cleaved Osteopontin

2000 • 81 citations

Differences in osteopontin up-regulation between proximal and distal tubules after renal ischemia/reperfusion

1999 • 80 citations

Heterogeneity of osteopontin expression among nephrons in mouse kidneys and enhanced expression in sclerotic glomeruli.

1993 • 79 citations

Inhibitory effects of female sex hormones on urinary stone formation in rats

1999 • 78 citations

De novo glomerular osteopontin expression in rat crescentic glomerulonephritis

1998 • 73 citations

Variable in vivo regulation of rat vitamin D-dependent genes (osteopontin, Ca,Mg-adenosine triphosphatase, and 25-hydroxyvitamin D3 24-hydroxylase): implications for differing mechanisms of regulation and involvement of multiple factors.

1995 • 67 citations

Adhesion of uric acid crystals to the surface of renal epithelial cells

2000 • 67 citations

Insulin-like growth factor I-enhanced renal expression of osteopontin after acute ischemic injury in rats.

1996 • 66 citations

Osteopontin expression in human crescentic glomerulonephritis

2000 • 65 citations

The Effect of Osteopontin on the Adhesion of Calcium Oxalate Crystals to Madin-Darby Canine Kidney Cells

1996 • 65 citations

Quantitative studies of human urinary excretion of uropontin

1998 • 65 citations

Osteopontin regulation in cultured rat renal epithelial cells

1997 • 62 citations

OSTEOPONTIN ANTISENSE OLIGONUCLEOTIDE INHIBITS ADHESION OF CALCIUM OXALATE CRYSTALS IN MADIN-DARBY CANINE KIDNEY CELL

1998 • 62 citations

Upregulation of osteopontin expression in renal cortex of streptozotocin-induced diabetic rats is mediated by bradykinin.

1998 • 56 citations

Osteopontin Inhibits Nucleation of Calcium Oxalate Crystals^a

1995 • 55 citations

CD44 and hyaluronan expression in the development of experimental crescentic glomerulonephritis

1997 • 53 citations

Osteopontin expressed by renal tubular epithelium mediates interstitial monocyte infiltration in rats

2000 • 51 citations

Interaction between Osteopontin on Madin Darby Canine Kidney Cell Membrane and Calcium Oxalate Crystal

1999 • 48 citations

Detection of Mouse Osteopontin by Western Blotting

1998 • 47 citations

Metanephric osteopontin regulates nephrogenesis in vitro

1997 • 46 citations

Tubular osteopontin expression in human glomerulonephritis and renal vasculitis

2000 • 45 citations

Enhanced Osteopontin Expression and Macrophage Infiltration in MRL- Fas ^lpr Mice with Lupus Nephritis

1998 • 44 citations

Osteopontin in chronic puromycin aminonucleoside nephrosis.

1997 • 43 citations

Mapping of the Cryptic Integrin-Binding Site in Osteopontin Suggests a New Mechanism by Which Thrombin Can Regulate Inflammation and Tissue Repair

2000 • 41 citations

Alpha-V/Beta-3 and Alpha-V/Beta-5 Integrin Distribution in Neoplastic Kidney

1996 • 41 citations

Ultrastructural localization of osteopontin in the kidney

1997 • 39 citations

De novo CD44 expression by proliferating mesangial cells in rat anti-Thy-1 nephritis.

1996 • 38 citations

Differential processing of osteopontin transcripts in rat kidney- and osteoblast-derived cell lines.

1992 • 35 citations

Expression of osteopontin messenger RNA in the rat kidney on experimental model of renal stone.

1995 • 31 citations

Osteopontin expression, tubulointerstitial disease, and essential hypertension

1998 • 29 citations

The carboxyl‐terminal fragment of osteopontin suppresses arginine‐glycine‐asparatic acid‐dependent cell adhesion

1998 • 29 citations

Renal Osteopontin Expression in Experimental Urolithiasis

1998 • 28 citations

Reduced Urinary Excretion of Intact Osteopontin in Patients With IgA Nephropathy

2001 • 26 citations

Lack of In Vivo Function of Osteopontin in Experimental Anti-GBM Nephritis

2000 • 24 citations

The complex role of osteopontin in renal disease

1998 • 21 citations

Osteopontin Expression in the Kidney during Unilateral Ureteral Obstruction

1998 • 20 citations

Expression of CD44 adhesion molecules in nonpapillary renal cell carcinoma and normal kidneys

1999 • 17 citations

Osteopontin Gene Expression and Protein Synthesis in Cultured Rat Mesangial Cells

1997 • 17 citations

Upregulation of Osteopontin in Ischemia-Induced Renal Failure in Rats: A Role for ET-1?

1997 • 16 citations

Renal expression of osteopontin and alkaline phosphatase correlates with BUN levels in aged rats

1995 • 15 citations

Alendronate inhibits osteopontin expression enhanced by parathyroid hormone-related peptide (PTHrP) in the rat kidney

1998 • 12 citations

Ultrastructural Osteopontin Localization in Papillary Stones Induced in Rats

1997 • 12 citations

THE INFLUENCE OF DIETARY LIPIDS ON NEPHROLITHIASIS IN RATS

1998 • 10 citations

Mycophenolic acid inhibits PDGF-induced osteopontin expression in rat mesangial cells

1999 • 10 citations

Individual or combined effects of enalapril and verapamil on chronic cyclosporine nephrotoxicity in rats

1999 • 6 citations

αv Integrin regulates TNF-α-induced nitric oxide synthesis in rat mesangial cells—possible role of osteopontin

1999 • 6 citations

Decreased osteopontin expression in the rat kidney on a sodium deficient diet

2000 • 2 citations