Apoptotic Cell Death and Caspase‐3 Activation Induced by N‐Methyl‐<scp>d</scp>‐Aspartate Receptor Antagonists and Their Prevention by Insulin‐Like Growth Factor I

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1995 • 1,892 citations

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

1986 • 1,842 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

NMDA receptors - their role in long-term potentiation

1987 • 1,177 citations

Actions of Insulin-Like Growth Factors

1985 • 1,141 citations

Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists

1988 • 983 citations

Intracellular Signaling Pathways Activated by Neuropathic Factors

1996 • 958 citations

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

1993 • 886 citations

Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors

1996 • 783 citations

Developmental changes in distribution of NMDA receptor channel subunit mRNAs

1992 • 718 citations

Synaptic plasticity in the hippocampus: LTP and LTD

1994 • 653 citations

Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil

1987 • 647 citations

Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons

1995 • 629 citations

Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway

1998 • 612 citations

Ischemia-induced neuronal apoptosis

1996 • 600 citations

Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II

1990 • 529 citations

Rat cortical neurons in cell culture: Culture methods, cell morphology, electrophysiology, and synapse formation

1978 • 482 citations

Insulin-like growth factor I increases brain growth and central nervous system myelination in tTransgenic mice

1993 • 468 citations

Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis

1995 • 403 citations

Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss

1995 • 356 citations

Potassium Deprivation-Induced Apoptosis of Cerebellar Granule Neurons: A Sequential Requirement for New mRNA and Protein Synthesis, ICE-Like Protease Activity, and Reactive Oxygen Species

1996 • 324 citations

Activation of the CED3/ICE-Related Protease CPP32 in Cerebellar Granule Neurons Undergoing Apoptosis But Not Necrosis

1997 • 284 citations

Blockade of glutamate receptors unmasks neuronal apoptosis after oxygen-glucose deprivation in vitro

1995 • 258 citations

Akt-Dependent and -Independent Survival Signaling Pathways Utilized by Insulin-Like Growth Factor I

1998 • 248 citations

Depolarization or glutamate receptor activation blocks apoptotic cell death of cultured cerebellar granule neurons

1994 • 175 citations

Glutamate‐Induced Neuronal Death Is Not a Programmed Cell Death in Cerebellar Culture

1993 • 160 citations

receptors influence neuronal survival in developing spinal cord cultures

1990 • 68 citations

Protection by ethanol of cortical neurons from N-methyl-d-aspartate-induced neurotoxicity is associated with blocking calcium influx

1990 • 65 citations

Ultrastructure of excitotoxic neuronal death in murine cortical culture

1995 • 55 citations

Delayed application of aurintricarboxylic acid reduces glutamate‐induced cortical neuronal injury

1994 • 54 citations

Developmental expression of NMDA receptor subunits and the emergence of glutamate neurotoxicity in primary cultures of murine cerebral cortical neurons

1998 • 53 citations

Apoptotic Cell Death and Caspase 3 (CPP32) Activation Induced by Calcium Ionophore at Low Concentrations and their Prevention by Nerve Growth Factor in PC12 Cells

1997 • 48 citations

Nerve cell death induced in vivo by kainic acid and quinolinic acid does not involve apoptosis

1991 • 41 citations

Apoptotic cell death and CPP32-like activation induced by thapsigargin and their prevention by nerve growth factor in PC12 cells

1998 • 30 citations

Dizocilpine (MK801): use or abuse?

1998 • 21 citations

A glutamate dehydrogenase-based method for the assay ofl-glutamic acid: Formation of pyridine nucleotide fluorescent derivatives

1989 • 21 citations