Blockade of glutamate receptors unmasks neuronal apoptosis after oxygen-glucose deprivation in vitro

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1984 • 2,884 citations

The Role of Glutamate Neurotoxicity in Hypoxic-Ischemic Neuronal Death

1990 • 2,204 citations

Ionic dependence of glutamate neurotoxicity

1987 • 1,811 citations

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1984 • 1,689 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

1992 • 964 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats.

1993 • 703 citations

Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury

1993 • 694 citations

The neurotoxicity of excitatory amino acids is produced by passive chloride influx

1985 • 634 citations

Rapid Communication: Oxidative Stress Induces Apoptosis in Embryonic Cortical Neurons

1994 • 588 citations

Free radical damage to protein and DNA: Mechanisms involved and relevant observations on brain undergoing oxidative stress

1992 • 539 citations

Free Radicals and Brain Damage

1993 • 527 citations

Induction of a Common Pathway of Apoptosis by Staurosporine

1994 • 491 citations

Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain

1993 • 481 citations

Mitochondrial respiratory chain inhibitors induce apoptosis

1994 • 403 citations

Potentiated Necrosis of Cultured Cortical Neurons by Neurotrophins

1995 • 360 citations

Apoptosis and necrosis. Basic types and mechanisms of cell death.

1993 • 353 citations

Molecular Mechanisms of Developmental Neuronal Death

1993 • 330 citations

N-methyl-D-aspartate receptors mediate hypoxic neuronal injury in cortical culture.

1987 • 309 citations

The role of specific ions in glutamate neurotoxicity

1986 • 298 citations

Reduction of delayed neuronal death by inhibition of protein synthesis

1990 • 190 citations

Glutamate‐Induced Neuronal Death Is Not a Programmed Cell Death in Cerebellar Culture

1993 • 160 citations

Internucleosomal DNA Cleavage Involved in Ischemia-Induced Neuronal Death

1993 • 139 citations

Ischemia‐Induced Translocation of Ca²⁺/Calmodulin‐Dependent Protein Kinase II: Potential Role in Neuronal Damage

1992 • 134 citations

Programmed cell death: its possible contribution to neurotoxicity mediated by calcium channel antagonists

1992 • 117 citations

Antagonism of non-NMDA receptors augments the neuroprotective effect of NMDA receptor blockade in cortical cultures subjected to prolonged deprivation of oxygen and glucose

1991 • 110 citations

Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes.

1993 • 85 citations

Delayed application of aurintricarboxylic acid reduces glutamate‐induced cortical neuronal injury

1994 • 54 citations

Energy metabolism and selective neuronal vulnerability following global cerebral ischemia

1992 • 49 citations

Oxygen Deficiency and Brain Damage: Localization, Evolution in Time, and Mechanisms of Damage

1985 • 30 citations

Role of calcium in inactivation of calcium/calmodulin dependent protein kinase II after cerebral ischemia

1992 • 14 citations