Bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania tropica: sequence homology with the corresponding monofunctional proteins.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

1978 • 4,566 citations

Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs

1984 • 3,334 citations

Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins

1986 • 836 citations

The relationship between base composition and codon usage in bacterial genes and its use for the simple and reliable identification of protein-coding sequences

1984 • 820 citations

Crystal structure of avian dihydrofolate reductase containing phenyltriazine and NADPH.

1982 • 219 citations

Purification and characterization of the bifunctional thymidylate synthetase-dihydrofolate reductase from methotrexate-resistant Leishmania tropica

1985 • 157 citations

A bifunctional thymidylate synthetase-dihydrofolate reductase in protozoa

1984 • 145 citations

Nucleotide sequence of a functional cDNA for human thymidylate synthase

1985 • 141 citations

Dihydrofolate reductase: thymidylate synthase, a bifunctional polypeptide from Crithidia fasciculata.

1980 • 130 citations

A 5' spliced leader is added in trans to both alpha- and beta-tubulin transcripts in Trypanosoma brucei.

1985 • 88 citations

Studies on identifying the folylpolyglutamate binding sites of Lactobacillus casei thymidylate synthetase

1982 • 46 citations

Nucleotide sequence reveals overlap between T4 phage genes encoding dihydrofolate reductase and thymidylate synthase.

1984 • 43 citations

The Carboxypeptidase-dependent Inactivation of Thymidylate Synthetase

1974 • 39 citations

DNA amplification in antifolate-resistant Leishmania. The thymidylate synthase-dihydrofolate reductase gene and abundant mRNAs.

1985 • 35 citations

Limited proteolysis of the bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania tropica.

1985 • 18 citations

Coregulation of dihydrofolate reductase and thymidylate synthase B in Bacillus subtilis

1985 • 12 citations

Interaction of thymidylate synthetase and dihydrofolate reductase enzymes in vitro and in vivo.

1974 • 9 citations