ABCG2 Expression and Side Population Abundance Regulated by a Transforming Growth Factor β–Directed Epithelial-Mesenchymal Transition

Prospective identification of tumorigenic breast cancer cells

2003 • 10,067 citations

Stem cells, cancer, and cancer stem cells

2001 • 9,488 citations

Epithelial–mesenchymal transitions in tumour progression

2002 • 6,431 citations

Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo.

1996 • 2,901 citations

In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells

2003 • 2,344 citations

The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

2001 • 2,274 citations

A multidrug resistance transporter from human MCF-7 breast cancer cells

1998 • 2,273 citations

Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion

2004 • 2,220 citations

Tumor metastasis: mechanistic insights and clinical challenges

2006 • 2,024 citations

Generation of a functional mammary gland from a single stem cell

2006 • 1,939 citations

Epithelial–mesenchymal transitions in development and pathologies

2003 • 1,700 citations

Applying the principles of stem-cell biology to cancer

2003 • 1,623 citations

TGF-β and epithelial-to-mesenchymal transitions

2005 • 1,508 citations

Purification and unique properties of mammary epithelial stem cells

2006 • 1,502 citations

A distinct “side population” of cells with high drug efflux capacity in human tumor cells

2004 • 1,259 citations

TGFβ: the molecular Jekyll and Hyde of cancer

2006 • 1,228 citations

Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)

2003 • 1,027 citations

Transforming Growth Factor-β1 Mediates Epithelial to Mesenchymal Transdifferentiation through a RhoA-dependent Mechanism

2001 • 993 citations

Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line

2004 • 983 citations

Side Population in Human Lung Cancer Cell Lines and Tumors Is Enriched with Stem-like Cancer Cells

2007 • 939 citations

TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors.

1994 • 937 citations

Side Population Is Enriched in Tumorigenic, Stem-Like Cancer Cells, whereas ABCG2+ and ABCG2− Cancer Cells Are Similarly Tumorigenic

2005 • 905 citations

Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C.

2002 • 682 citations

Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis

2003 • 679 citations

The Stem Cell Marker Bcrp/ABCG2 Enhances Hypoxic Cell Survival through Interactions with Heme

2004 • 648 citations

Therapeutic implications of cancer stem cells

2003 • 562 citations

The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2)

2000 • 528 citations

Sca-1pos Cells in the Mouse Mammary Gland Represent an Enriched Progenitor Cell Population

2002 • 523 citations

Bcrp1gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cellsin vivo

2002 • 506 citations

Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein.

2000 • 494 citations

ABC Transporters as Phenotypic Markers and Functional Regulators of Stem Cells

2002 • 461 citations

Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties

2002 • 381 citations

A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemia

2001 • 329 citations

Timing of cyclin D1 expression within G1 phase is controlled by Rho

2001 • 318 citations

Functional Characterization of the Human Multidrug Transporter, ABCG2, Expressed in Insect Cells

2001 • 310 citations

Functional and molecular characterisation of mammary side population cells

2002 • 294 citations

The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells

2004 • 292 citations

Sustained TGFβ exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis

2007 • 208 citations

Transforming Growth Factor-β Signaling in Stem Cells and Cancer

2005 • 188 citations

Growth and differentiation of progenitor/stem cells derived from the human mammary gland

2004 • 177 citations

Mechanisms of resistance to anticancer drugs: the role of the polymorphic ABC transporters ABCB1 and ABCG2

2005 • 121 citations

Hoechst 33342 efflux identifies a subpopulation of cytogenetically normal CD34+CD38− progenitor cells from patients with acute myeloid leukemia

2001 • 120 citations

Isolation and characterization of functional mammary gland stem cells

2003 • 113 citations

Novel camptothecin analogues that circumvent ABCG2‐associated drug resistance in human tumor cells

2004 • 61 citations

Cell Adhesion, Cellular Tension, and Cell Cycle Control

2007 • 59 citations

Site-selective growth of a hormone-responsive human breast carcinoma in athymic mice.

1982 • 32 citations