A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemia

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

1997 • 6,760 citations

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

1994 • 4,563 citations

Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo.

1996 • 2,901 citations

The Importance of Diagnostic Cytogenetics on Outcome in AML: Analysis of 1,612 Patients Entered Into the MRC AML 10 Trial

1998 • 2,668 citations

Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species

1997 • 1,116 citations

A newly discovered class of human hematopoietic cells with SCID-repopulating activity

1998 • 640 citations

Antigen CD34+ marrow cells engraft lethally irradiated baboons.

1988 • 608 citations

Engraftment of Immune-Deficient Mice with Human Hematopoietic Stem Cells

1988 • 471 citations

Quiescence, cycling, and turnover in the primitive hematopoietic stem cell compartment.

1997 • 431 citations

Reversible Expression of CD34 by Murine Hematopoietic Stem Cells

1999 • 408 citations

Lack of Expression of Thy-1 (CD90) on Acute Myeloid Leukemia Cells With Long-Term Proliferative Ability In Vitro and In Vivo

1997 • 341 citations

In vivo and in vitro characterization of long-term repopulating primitive hematopoietic cells isolated by sequential Hoechst 33342-rhodamine 123 FACS selection.

1993 • 271 citations

Acute nonlymphocytic leukemia: heterogeneity of stem cell origin

1981 • 259 citations

Most Acute Myeloid Leukemia Progenitor Cells With Long-Term Proliferative Ability In Vitro and In Vivo Have the Phenotype CD34+/CD71−/HLA-DR−

1998 • 239 citations

Acute nonlymphocytic leukemia: heterogeneity of stem cell origin

1981 • 215 citations

Growth Characteristics of Acute Myelogenous Leukemia Progenitors That Initiate Malignant Hematopoiesis in Nonobese Diabetic/Severe Combined Immunodeficient Mice

1999 • 160 citations

Clonal Chromosomal Abnormalities Showing Multiple-Cell-Lineage Involvement in Acute Myeloid Leukemia

1988 • 114 citations

Fluorouracil selectively spares acute myeloid leukemia cells with long- term growth abilities in immunodeficient mice and in culture

1996 • 111 citations

Human endogenous retroviruslike genome with type C pol sequences and gag sequences related to human T-cell lymphotropic viruses

1987 • 102 citations

Isolation of primitive human bone marrow hematopoietic progenitor cells using Hoechst 33342 and Rhodamine 123.

1996 • 95 citations

Long-term leukemia-initiating capacity of a CD34-subpopulation of acute myeloid leukemia

1996 • 80 citations

Hoechst 33342 Induces Apoptosis in HL-60 Cells and Inhibits Topoisomerase I In Vivo

1999 • 55 citations

Engraftment and Multilineage Expression of Human Bone Marrow CD34⁻ Cells In Vivo^a

1999 • 53 citations

Multilineage Long-Term Engraftment Potential of Drug-Resistant Hematopoietic Progenitors

1997 • 31 citations

Minimal residual disease in acute myelogenous leukaemia and myelodysplastic syndromes: a follow‐up of patients in clinical remission

1997 • 28 citations

Quantitation of minimal residual disease in acute myelogenous leukemia and myelodysplastic syndromes in complete remission by molecular cytogenetics of progenitor cells

1999 • 28 citations

In AML t(8;21) colony growth of both leukemic and residual normal progenitors is restricted to the CD34+, lineage-negative fraction

1998 • 17 citations

Purification and Expansion of Human Hematopoietic Stem/Progenitor Cells

1995 • 15 citations

Activation and inhibition of the sarcoplasmic reticulum Ca2+ channel by the polycationic dyes Hoechst 33342 and Hoechst 33258

1993 • 8 citations