Signaling from synapse to nucleus: the logic behind the mechanisms

The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function

2003 • 3,746 citations

Function and Regulation of CREB Family Transcription Factors in the Nervous System

2002 • 2,037 citations

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

1999 • 1,897 citations

Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein

1994 • 1,802 citations

Neurotrophins as synaptic modulators

2001 • 1,773 citations

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

2002 • 1,612 citations

NFAT Signaling

2002 • 1,316 citations

Cognitive Neuroscience and the Study of Memory

1998 • 1,294 citations

CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression

1996 • 1,109 citations

Role of ion flux in the control of c-fos expression

1986 • 1,006 citations

Signaling to the Nucleus by an L-type Calcium Channel-Calmodulin Complex Through the MAP Kinase Pathway

2001 • 908 citations

Cross Talk between ERK and PKA Is Required for Ca2+ Stimulation of CREB-Dependent Transcription and ERK Nuclear Translocation

1998 • 885 citations

Regulation of CREB Phosphorylation in the Suprachiasmatic Nucleus by Light and a Circadian Clock

1993 • 817 citations

Signaling from Synapse to Nucleus: Postsynaptic CREB Phosphorylation during Multiple Forms of Hippocampal Synaptic Plasticity

1996 • 701 citations

Identification of a Signaling Pathway Involved in Calcium Regulation of BDNF Expression

1998 • 687 citations

Toward a molecular definition of long-term memory storage

1996 • 685 citations

MEF2: a calcium-dependent regulator of cell division, differentiation and death

2002 • 681 citations

Disruption of CREB function in brain leads to neurodegeneration

2002 • 674 citations

Activation of ERK/MAP Kinase in the Amygdala Is Required for Memory Consolidation of Pavlovian Fear Conditioning

2000 • 660 citations

Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons

1998 • 640 citations

CREB required for the stability of new and reactivated fear memories

2002 • 616 citations

Molecular Psychology: Roles for the ERK MAP Kinase Cascade in Memory

2002 • 596 citations

Regulation of transcription factors by neuronal activity

2002 • 584 citations

DREAM is a Ca2+-regulated transcriptional repressor

1999 • 567 citations

MAP Kinase Translocates into the Nucleus of the Presynaptic Cell and Is Required for Long-Term Facilitation in Aplysia

1997 • 548 citations

Molecular Genetics of Circadian Rhythms in Mammals

2000 • 541 citations

Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning

1998 • 532 citations

Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity

2001 • 530 citations

Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity

2002 • 529 citations

L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons

1999 • 521 citations

Memory consolidation of Pavlovian fear conditioning: a cellular and molecular perspective

2001 • 512 citations

Neuronal Activity-Dependent Cell Survival Mediated by Transcription Factor MEF2

1999 • 510 citations

Activity-dependent CREB phosphorylation: Convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway

2001 • 466 citations

Roles of Nuclear Factor κB in Neuronal Survival and Plasticity

2000 • 465 citations

Inducible and Reversible Enhancement of Learning, Memory, and Long-Term Potentiation by Genetic Inhibition of Calcineurin

2001 • 464 citations

Long-Term Memory Is Facilitated by cAMP Response Element-Binding Protein Overexpression in the Amygdala

2001 • 441 citations

NMDA Receptors and L-Type Voltage-Gated Calcium Channels Contribute to Long-Term Potentiation and Different Components of Fear Memory Formation in the Lateral Amygdala

2002 • 431 citations

Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology

2001 • 396 citations

Spaced training induces normal long-term memory in CREB mutant mice

1997 • 357 citations

Regulation of the transcriptional activity of the nuclear factor-κB p65 subunit

2002 • 305 citations

A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication

2001 • 290 citations

Ca2+-dependent regulation in neuronal gene expression

1997 • 290 citations

An Important Role of Neural Activity-Dependent CaMKIV Signaling in the Consolidation of Long-Term Memory

2001 • 285 citations

Circadian Regulation of cAMP Response Element-mediated Gene Expression in the Suprachiasmatic Nuclei

1999 • 282 citations

Imaging of cytosolic Ca2+ transients arising from Ca2+ stores and Ca2+ channels in sympathetic neurons

1988 • 281 citations

DREAM Is a Critical Transcriptional Repressor for Pain Modulation

2002 • 276 citations

Phosphorylation of CREB Ser142 Regulates Light-Induced Phase Shifts of the Circadian Clock

2002 • 263 citations

Impaired Synaptic Plasticity and cAMP Response Element-Binding Protein Activation in Ca²⁺/Calmodulin-Dependent Protein Kinase Type IV/Gr-Deficient Mice

2000 • 251 citations

L-Type Voltage-Gated Calcium Channels Mediate NMDA-Independent Associative Long-Term Potentiation at Thalamic Input Synapses to the Amygdala

1999 • 250 citations

NMDA Receptor-Mediated K⁺Efflux and Neuronal Apoptosis

1999 • 232 citations

Calcium–calmodulin-dependent protein kinase IV is required for fear memory

2002 • 223 citations

Type 1 Inositol 1,4,5-Trisphosphate Receptor Is Required for Induction of Long-Term Depression in Cerebellar Purkinje Neurons

1998 • 215 citations

Ca2+-dependent Gene Expression Mediated by MEF2 Transcription Factors

2000 • 196 citations

Critical Dependence of cAMP Response Element-Binding Protein Phosphorylation on L-Type Calcium Channels Supports a Selective Response to EPSPs in Preference to Action Potentials

2000 • 195 citations

Developmentally Regulated NMDA Receptor-Dependent Dephosphorylation of cAMP Response Element-Binding Protein (CREB) in Hippocampal Neurons

2000 • 190 citations

Cerebellar Defects in Ca²⁺/Calmodulin Kinase IV-Deficient Mice

2000 • 174 citations

Induction of c-fos expression in hypothalamic magnocellular neurons requires synaptic activation and not simply increased spike activity

1994 • 174 citations

Coupling of extrasynaptic NMDA receptors to a CREB shut-off pathway is developmentally regulated

2002 • 165 citations

Involvement of a Calcineurin Cascade in Amygdala Depotentiation and Quenching of Fear Memory

2003 • 158 citations

Calcium/calmodulin‐dependent protein kinase type IV (CaMKIV) inhibits apoptosis induced by potassium deprivation in cerebellar granule neurons

2001 • 140 citations

Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis

2002 • 135 citations

Interactions with PDZ Proteins Are Required for L-Type Calcium Channels to Activate cAMP Response Element-Binding Protein-Dependent Gene Expression

2003 • 134 citations

Dynamic Multiphosphorylation Passwords for Activity-Dependent Gene Expression

2002 • 129 citations

Calcium-regulated DNA Binding and Oligomerization of the Neuronal Calcium-sensing Protein, Calsenilin/DREAM/KChIP3

2001 • 128 citations

Myocyte Enhancer Factor 2A and 2D Undergo Phosphorylation and Caspase-Mediated Degradation during Apoptosis of Rat Cerebellar Granule Neurons

2001 • 126 citations

Somatic action potentials are sufficient for late-phase LTP-related cell signaling

2002 • 117 citations

Ca2+-regulated Dynamic Compartmentalization of Calmodulin in Living Smooth Muscle Cells

1995 • 106 citations

Calmodulin priming: Nuclear translocation of a calmodulin complex and the memory of prior neuronal activity

2001 • 104 citations

Hormone-induced secretory and nuclear translocation of calmodulin: Oscillations of calmodulin concentration with the nucleus as an integrator

1999 • 86 citations

A Role for L-Type Calcium Channels in Developmental Regulation of Transmitter Phenotype in Primary Sensory Neurons

1998 • 81 citations

Differential codes for free Ca2+–calmodulin signals in nucleus and cytosol

2000 • 64 citations

Voltage-dependent calcium channels — beyond dihydropyridine antagonists

2001 • 63 citations

Mechanism of Ca ²⁺ -dependent nuclear accumulation of calmodulin

1999 • 56 citations

Effects of synaptic and antidromic stimulation on tyrosine hydroxylase activity in the rat superior cervical ganglion.

1980 • 47 citations

Calcium and pituitary adenylate cyclase‐activating polypeptide induced expression of circadian clock gene mPer1 in the mouse cerebellar granule cell culture

2001 • 44 citations

Effect of different convulsants on calmodulin levels and proto-oncogene c-fos expression in the central nervous system

1992 • 42 citations

Nuclear Ca²⁺/Calmodulin Translocation Activated by μ‐Opioid(OP₃) Receptor

2000 • 42 citations

An evaluation of specificity in activity-dependent gene expression in neurons

2002 • 29 citations

Dopaminergic signalling in the rodent neonatal suprachiasmatic nucleus identifies a role for protein kinase A and mitogen‐activated protein kinase in circadian entrainment

2002 • 21 citations

Molecular Mechanisms of Neuronal Cell Death: Implications for Nuclear Factors Responding to cAMP and Phorbol Esters

2002 • 17 citations

Use of fluorescently labelled calmodulins as tools to measure subcellular calmodulin activation in living dorsal root ganglion cells

1999 • 11 citations

Use of fluorescently labelled calmodulins as tools to measure subcellular calmodulin activation in living dorsal root ganglion cells

2000 • 10 citations

Activity-Regulated Phosphorylation of cAMP Response Element Binding Protein in the Developing Striatum: Implications for Patterning the Neurochemical Phenotypes of Striatal Compartments

1998 • 8 citations