Coupling of extrasynaptic NMDA receptors to a CREB shut-off pathway is developmentally regulated

Pathobiology of ischaemic stroke: an integrated view

1999 • 3,776 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

Neuronal Calcium Signaling

1998 • 2,126 citations

Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain

1999 • 2,023 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

1999 • 1,897 citations

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1995 • 1,892 citations

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

2002 • 1,612 citations

Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism

1998 • 1,504 citations

CREB AND MEMORY

1998 • 1,421 citations

Cognitive Neuroscience and the Study of Memory

1998 • 1,294 citations

Proteomic analysis of NMDA receptor–adhesion protein signaling complexes

2000 • 1,201 citations

Regulation of Gene Expression in Hippocampal Neurons by Distinct Calcium Signaling Pathways

1993 • 1,165 citations

The changing landscape of ischaemic brain injury mechanisms

1999 • 1,111 citations

CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression

1996 • 1,109 citations

Requirement for BDNF in Activity-Dependent Survival of Cortical Neurons

1994 • 974 citations

Signaling to the Nucleus by an L-type Calcium Channel-Calmodulin Complex Through the MAP Kinase Pathway

2001 • 908 citations

Mediation by a CREB Family Transcription Factor of NGF-Dependent Survival of Sympathetic Neurons

1999 • 794 citations

Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective

1999 • 733 citations

Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression

1997 • 724 citations

Identification of a Signaling Pathway Involved in Calcium Regulation of BDNF Expression

1998 • 687 citations

Disruption of CREB function in brain leads to neurodegeneration

2002 • 674 citations

Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons

1998 • 640 citations

Mitochondrial membrane potential and neuronal glutamate excitotoxicity: mortality and millivolts

2000 • 564 citations

Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity

2001 • 530 citations

Is CREB a key to neuronal survival?

2000 • 516 citations

Generation, Control, and Processing of Cellular Calcium Signals

2001 • 516 citations

Stimulation of Protein Tyrosine Phosphorylation by NMDA Receptor Activation

1991 • 464 citations

CREB Couples Neurotrophin Signals to Survival Messages

2000 • 455 citations

Apoptosis, Axonal Growth Defects, and Degeneration of Peripheral Neurons in Mice Lacking CREB

2002 • 344 citations

Action Potential-Dependent Regulation of Gene Expression: Temporal Specificity in Ca²⁺, cAMP-Responsive Element Binding Proteins, and Mitogen-Activated Protein Kinase Signaling

1997 • 304 citations

A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication

2001 • 290 citations

Control of Recruitment and Transcription-Activating Function of CBP Determines Gene Regulation by NMDA Receptors and L-Type Calcium Channels

1999 • 278 citations

Developmentally Regulated NMDA Receptor-Dependent Dephosphorylation of cAMP Response Element-Binding Protein (CREB) in Hippocampal Neurons

2000 • 190 citations

Micromolar l-glutamate induces extensive apoptosis in an apoptotic-necrotic continuum of insult-dependent, excitotoxic injury in cultured cortical neurones

1998 • 173 citations

The role of the cyclic AMP-responsive element binding protein (CREB) in hypoxic-ischemic brain damage and repair

1996 • 119 citations

Calcium as a versatile second messenger in the control of gene expression

1999 • 86 citations

Immunohistochemical analysis of cyclic AMP response element binding protein phosphorylation in focal cerebral ischemia in rats

1999 • 68 citations

Shakespeare in love—with NMDA receptors?

1999 • 63 citations

CREB/CBP and SRE‐interacting transcriptional regulators are fast on–off switches: duration of calcium transients specifies the magnitude of transcriptional responses

2001 • 58 citations