Nutritional and Pharmacological Factors in Eicosanoid Biology

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

1975 • 3,075 citations

Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

1980 • 2,099 citations

EICOSAPENTAENOIC ACID AND PREVENTION OF THROMBOSIS AND ATHEROSCLEROSIS?

1978 • 1,689 citations

Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin.

1978 • 1,559 citations

Aspirin Selectively Inhibits Prostaglandin Production in Human Platelets

1971 • 1,535 citations

Prostaglandin Endoperoxides. Novel Transformations of Arachidonic Acid in Human Platelets

1974 • 1,410 citations

A NEW DEFICIENCY DISEASE PRODUCED BY THE RIGID EXCLUSION OF FAT FROM THE DIET

1929 • 1,140 citations

HÆMOSTATIC FUNCTION AND PLATELET POLYUNSATURATED FATTY ACIDS IN ESKIMOS

1979 • 1,012 citations

Isolation and Structure of Two Prostaglandin Endoperoxides That Cause Platelet Aggregation

1974 • 1,004 citations

Acetylation of prostaglandin synthase by aspirin.

1975 • 1,003 citations

The Composition of Food Consumed by Greenland Eskimos

1976 • 964 citations

ON THE NATURE AND RÔLE OF THE FATTY ACIDS ESSENTIAL IN NUTRITION

1930 • 961 citations

Indomethacin and Aspirin abolish Prostaglandin Release from the Spleen

1971 • 940 citations

Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids

1980 • 925 citations

Arachidonic acid metabolism in polymorphonuclear leukocytes

1979 • 812 citations

Isolation and properties of intermediates in prostaglandin biosynthesis

1973 • 796 citations

Triene prostaglandins: Prostacyclin and thromboxane biosynthesis and unique biological properties

1979 • 786 citations

Cancer Research: Some Forward Steps

1965 • 733 citations

The chemical structure of prostaglandin X (prostacyclin)

1976 • 729 citations

Handbook of Biochemistry and Molecular Biology

2010 • 719 citations

Measurement of lipid oxidation: A review

1978 • 711 citations

Advances in prostaglandin and thromboxane research

1980 • 675 citations

Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes. Formation of a novel dihydroxyeicosatetraenoic acid.

1979 • 652 citations

Arachidonate lipoxygenase in blood platelets

1975 • 613 citations

The prostaglandins: a family of biologically active lipids.

1968 • 613 citations

A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation

1976 • 606 citations

Increased concentrations of nonesterified arachidonic acid, 12L-hydroxy-5,8,10,14-eicosatetraenoic acid, prostaglandin E2, and prostaglandin F2alpha in epidermis of psoriasis.

1975 • 583 citations

Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids.

1976 • 573 citations

PLATELET-MEMBRANE FATTY ACIDS, PLATELET AGGREGATION, AND THROMBOXANE FORMATION DURING A MACKEREL DIET

1980 • 551 citations

PSYCHOLOGICAL STRESS AND FATAL HEART ATTACK: THE ATHENS (1981) EARTHQUAKE NATURAL EXPERIMENT

1983 • 542 citations

Effects of Anti-inflammatory Drugs on Prostaglandin Biosynthesis

1972 • 478 citations

On the specific vaso‐dilating and plain muscle stimulating substances from accessory genital glands in man and certain animals (prostaglandin and vesiglandin)

1936 • 452 citations

Selective Inhibitor of Slow Reacting Substance of Anaphylaxis

1973 • 443 citations

Structure of slow-reacting substance of anaphylaxis from guinea-pig lung

1980 • 426 citations

DIPYRIDAMOLE AND OTHER PHOSPHODIESTERASE INHIBITORS ACT AS ANTITHROMBOTIC AGENTS BY POTENTIATING ENDOGENOUS PROSTACYCLIN

1978 • 392 citations

Thromboxanes: Selective Biosynthesis and Distinct Biological Properties

1976 • 390 citations

A Possible Essential Role for Dietary Linolenic Acid in the Development of the Young Rat

1976 • 367 citations

The Biosynthesis and Metabolism of Prostaglandins

1979 • 366 citations

BATTERED BABIES—HOW MANY DO WE MISS?

1970 • 365 citations

Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea pig

1975 • 339 citations

Phospholipid precursors of prostaglandins

1968 • 333 citations

Inhibition of prostaglandin biosynthesis by eicosapentaenoic acid

1979 • 318 citations

Release of Noradrenaline from Sympathetic Endings

1971 • 316 citations

Provision of medicine in Ecuador.

1980 • 314 citations

PHOSPHOLIPASE A₂ ACTIVITY OF GUINEA‐PIG ISOLATED PERFUSED LUNGS: STIMULATION, AND INHIBITION BY ANTI‐INFLAMMATORY STEROIDS

1978 • 310 citations

Further studies on the enzymatic conversion of prostaglandin endoperoxide into prostacyclin by porcine aorta microsomes

1978 • 306 citations

Structure of leukotriene C identification of the amino acid part

1979 • 304 citations

Effect of Prostaglandin E1 on Adjuvant Arthritis

1971 • 264 citations

Selective inhibition by mepacrine of the release of “rabbit aorta contracting substance” evoked by the administration of bradykinin

1972 • 249 citations

Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea pig

1975 • 233 citations

Prostaglandin D2 inhibits the aggregation of human platelets

1974 • 230 citations

Cyclic Nucleotide Phosphodiesterases: Properties, Activators, Inhibitors, Structure–Activity Relationships, and Possible Role in Drug Development

1975 • 206 citations

Lipids, Malnutrition and the Developing Brain

1972 • 191 citations

Conversion of prostaglandin endoperoxides to C₁₇‐hydroxy acids catalyzed by human platelet thromboxane synthase

1977 • 188 citations

An endoperoxide aggregator (LASS), formed in platelets in response to thrombotic stimuli-purification, identification and unique biological significance

1974 • 178 citations

Prostaglandin endoperoxide and thromboxane generating systems and their selective inhibition

1976 • 176 citations

Inhibition of prostaglandin biosynthesis by corticosteroids requires RNA and protein synthesis

1978 • 170 citations

Growth Hormone and Premature Ageing

1973 • 163 citations

Nomenclature for leukotrienes

1980 • 157 citations

Effects of all CIS-5, 8,11,14,17 eicosapentaenoic acid and PGH3 on platelet aggregation

1979 • 154 citations

Antithrombotic potential of dihomo-gamma-linolenic acid in man.

1977 • 152 citations

EFFECT OF ANTI-INFLAMMATORY AGENTS ON PLATELETS

1968 • 148 citations

THROMBOXANE SYNTHETASE INHIBITION AS ANTITHROMBOTIC STRATEGY

1981 • 145 citations

ISomerization of prostaglandin H2 into prostaglandin D2 in the presence of serum albumin

1976 • 137 citations

The metabolism of dihomo‐γ‐linolenic acid in man

1979 • 132 citations

Manipulation of platelet aggregation by prostaglandins and their fatty acid precursors: Pharmacological basis for a therapeutic approach

1980 • 129 citations

Duration of inhibition of platelet prostaglandin formation and aggregation by ingested aspirin or indomethacin

1973 • 127 citations

Triene prostaglandins: Prostaglandin D ₃ and icosapentaenoic acid as potential antithrombotic substances

1979 • 122 citations

Inhibition of human platelet thromboxane synthetase by 9,11-azoprosta-5,13-dienoic acid.

1977 • 111 citations

An Enzymatic Mechanism for the Antithrombotic and Antihemostatic Actions of Aspirin

1974 • 107 citations

Metabolism of 8,11,14-eicosatrienoic acid in human platelets

1976 • 105 citations

Isolation of a chemical trigger for thrombosis

1974 • 103 citations

Dihomo-γ-linolenate suppresses platelet aggregation when administered in vitro or in vivo

1974 • 102 citations

Effect of Prostaglandin E2 and Aspirin on the Secondary Aggregation of Human Platelets

1972 • 101 citations

Current Trends in the Biochemistry of Lipids

1973 • 101 citations

The incorporation of orally fed radioactive γ‐linolenic acid and linoleic acid into the liver and brain lipids of suckling rats

1975 • 87 citations

Prostaglandins and Related Compounds

1978 • 86 citations

Interaction between prostaglandins E and F given intradermally in the rat

1971 • 77 citations

Inhibition of renal PGE2-9-ketoreductase by diuretics

1976 • 75 citations

Release and Actions of Prostaglandins in Inflammation and Fever: Inhibition by Anti-Inflammatory and Antipyretic Drugs

1972 • 74 citations

19-Hydroxyprostaglandin E1 as a major component of the semen of primates

1976 • 72 citations

Substances That Inhibit the Actions of Prostaglandins

1974 • 71 citations

Prostaglandins in hematology

1974 • 66 citations

Reduced exudation and increased tissue proliferation during chronic inflammation in rats deprived of endogenous prostaglandin precursors

1977 • 64 citations

Selective inhibition of prostaglandin biosynthesis by gold salts and phenylbutazone

1975 • 62 citations

Prostaglandin-E2-9-ketoreductase in rabbit kidney

1975 • 62 citations

Persistence of thromboxane A2-like material and platelet release-inducing activity in plasma.

1976 • 61 citations

Prostaglandin biosynthesis by human skin and its inhibition by corticosteroids

1972 • 59 citations

Cellular Mechanisms of Prostaglandin Action

1979 • 57 citations

Purification and regulatory properties of chicken heart prostaglandin E 9-ketoreductase.

1975 • 56 citations

The activity of γ-linolenate and dihomo-γ-linolenate methyl esters in vitro and in vivo on blood platelet function in non-human primates and in man

1977 • 53 citations

Reproduction and survival of rainbow trout (Salmo gairdneri) fed linolenic acid as the only source of essential fatty acids

1979 • 50 citations

Selective inhibition of prostaglandin biosynthesis by gold salts and phenylbutazone

1975 • 49 citations

The nature of the prostaglandin-blocking activity of polyphloretin phosphate.

1971 • 44 citations

Purification of the human placental 15 hydroxy prostaglandin dehydrogenase: Properties of the purified enzyme

1974 • 43 citations

Diet‐induced alterations in the discoid shape and phospholipid fatty acid compositions of rat erythrocytes

1979 • 39 citations

Alterations of prostaglandin E2-9-ketoreductase activity in proliferating skin

1977 • 31 citations

Thromboxane synthase from bovine lung — Solubilization and partial purification

1978 • 30 citations

Distribution studies on the reduction of prostaglandin E2 to prostaglandin F2α by tissue homogenates

1975 • 28 citations

Leukotrienes: A novel group of compounds including SRS-A

1981 • 28 citations

Prostaglandins and Body Temperature

1978 • 28 citations

Clot-Promoting Effect of Platelet-Vessel Wall Interaction: Influence of Dietary Fats and Relation to Arterial Thrombus Formation in Rats

1979 • 26 citations

Biomimetic reduction with non water-sensivive NADH models

1986 • 24 citations

Protective effects of a novel thromboxane analog in lethal traumatic shock

1979 • 22 citations

Phosphatidic acid in the central nervous system

1981 • 22 citations

A structural requirement for the conversion of prostaglandin endoperoxides to thromboxanes

1979 • 22 citations

Synthesis of prostaglandin I3 (PGI3)

1978 • 21 citations

Fatty acid composition of human and rat adrenal lipids: Occurrence of ω6 docosatrienoic acid in human adrenal cholesterol ester

1970 • 21 citations

Dietary management in multiple sclerosis

1979 • 20 citations

Inhibition of aggregation of human platelets by 8,15-dihydroperoxides of 5,9,11,13-eicosatetraenoic and 9,11,13-eicosatrienoic acids

1978 • 20 citations

Dihomogammalinolenic acid (20:3ω6) is more anti-aggregatory than eicosapentaenoic (20:5ω3) in a platelet-endothelial cell mixture

1980 • 16 citations

Platelet Aggregation Mechanisms and Their Implications in Haemostasis and Inflammatory Disease

1978 • 15 citations

Albumin-Bound Fatty Acids, Platelets and Endothelial Cells in Thrombogenesis

1979 • 14 citations

Prostaglandin Antagonists

1972 • 14 citations

A 15-hydroxyprostaglandin dehydrogenase specific for prostaglandin A in rabbit kidney.

1976 • 12 citations

On the metabolism of prostaglandins by rat brain homogenate

1976 • 10 citations

Homo‐gamma‐linolenic acid: A major polyunsaturated fatty acid of swine adrenal cholesteryl esters

1971 • 9 citations

Structure elucidation and biosynthesis of slow reacting substances and slow reacting substance of anaphylaxis from guinea pig and human lungs

1981 • 6 citations

ARE ESKIMOS OBLIGATE CARNIVORES?

1981 • 6 citations

The forty-year quest of “slow-reacting substance of anaphylaxis”

1981 • 4 citations