Type 1 (insulin-dependent) diabetes mellitus and nitric oxide

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells.

1990 • 1,117 citations

Insulin Secretion from Pancreatic B Cells Caused by L-Arginine-Derived Nitrogen Oxides

1992 • 415 citations

Inhibition of insulin secretion by interleukin‐1β and tumour necrosis factor‐α via an L‐arginine‐dependent nitric oxide generating mechanism

1990 • 362 citations

Interleukin-lβ-Induced Nitric Oxide Production in Isolated Rat Pancreatic Islets Requires Gene Transcription and May Lead to Inhibition of the Krebs Cycle Enzyme Aconitase*

1991 • 317 citations

Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion.

1991 • 257 citations

Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation

1991 • 257 citations

Preventive and Therapeutic Effects of Large-Dose Nicotinamide Injections on Diabetes Associated with Insulitis: An Observation in Nonobese Diabetic (NOD) Mice

1982 • 221 citations

Inhibition of nitric oxide generation affects the induction of diabetes by streptozocin in mice

1991 • 148 citations

Mechanisms of pancreatic beta-cell destruction in type I diabetes.

1988 • 145 citations

Cytotoxic action of IL-1β against pancreatic islets is mediated via nitric oxide formation and is inhibited byN^G-monomethyl-<scp>l</scp>-arginine

1992 • 95 citations

Suppression of low dose streptozotocin induced diabetes in mice by administration of a nitric oxide synthase inhibitor

1991 • 91 citations

Interleukin-1β induces nitric oxide production and inhibits the activity of aconitase without decreasing glucose oxidation rates in isolated mouse pancreatic islets

1992 • 91 citations

Essential contribution of macrophages to islet cell destruction in vivo and in vitro

1990 • 57 citations