RegulatedCYP19Aromatase Transcription in Breast Stromal Fibroblasts1

Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene.

1996 • 418 citations

Aromatization of Androgens by Muscle and Adipose Tissue in Vivo*

1978 • 392 citations

Conversion of blood androgens to estrogens in normal adult men and women

1969 • 369 citations

Tissue-specific expression of the human aromatase cytochrome P-450 gene by alternative use of multiple exons 1 and promoters, and switching of tissue-specific exons 1 in carcinogenesis.

1993 • 361 citations

A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription.

1993 • 337 citations

Structural analysis of the gene encoding human aromatase cytochrome P-450, the enzyme responsible for estrogen biosynthesis

1989 • 323 citations

Tissue-specific and hormonally controlled alternative promoters regulate aromatase cytochrome P450 gene expression in human adipose tissue.

1993 • 303 citations

Tissue-Specific Promoters Regulate Aromatase Cytochrome P450 Gene Expression in Human Ovary and Fetal Tissues

1991 • 257 citations

Keratin expression in human mammary epithelial cells cultured from normal and malignant tissue: relation to in vivo phenotypes and influence of medium

1989 • 251 citations

Use of alternative promoters to express the aromatase cytochrome P450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients.

1996 • 250 citations

CONCENTRATION OF OESTROGENS AND ANDROGENS IN HUMAN OVARIAN VENOUS PLASMA AND FOLLICULAR FLUID THROUGHOUT THE MENSTRUAL CYCLE

1976 • 235 citations

Intratumoral Aromatase in Human Breast, Endometrial, and Ovarian Malignancies*

1998 • 215 citations

In situ aromatization enhances breast tumor estradiol levels and cellular proliferation.

1998 • 213 citations

Stable expression of human aromatase complementary DNA in mammalian cells: a useful system for aromatase inhibitor screening.

1990 • 205 citations

Growth factor messenger RNA expression by human breast fibroblasts from benign and malignant lesions.

1991 • 204 citations

Expression of aromatase protein and messenger ribonucleic acid in tumor epithelial cells and evidence of functional significance of locally produced estrogen in human breast cancers.

1996 • 177 citations

Estrogen formation in stromal cells of adipose tissue of women: induction by glucocorticosteroids.

1981 • 174 citations

Detection of intratumoral aromatase in breast carcinomas. An immunohistochemical study with clinicopathologic correlation.

1992 • 162 citations

in situ oestrone synthesis in normal breast and breast tumour tissues: Effect of treatment with 4‐hydroxyandrostenedione

1989 • 157 citations

Stromal spindle cells contain aromatase in human breast tumors.

1994 • 148 citations

Aromatase activity in breast tissue

1991 • 144 citations

Characterization of the sequences of the human CYP19 (aromatase) gene that mediate regulation by glucocorticoids in adipose stromal cells and fetal hepatocytes.

1995 • 139 citations

Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene

1996 • 138 citations

Generation and genetic characterization of immortal human prostate epithelial cell lines derived from primary cancer specimens.

1997 • 138 citations

Aromatase activity in primary and metastatic human breast cancer

1987 • 137 citations

Malignant breast epithelium selects for insulin-like growth factor II expression in breast stroma: evidence for paracrine function.

1995 • 134 citations

Aromatase gene expression and its exon I usage in human breast tumors. Detection of aromatase messenger RNA by reverse transcription-polymerase chain reaction

1996 • 134 citations

Biological Significance of Aromatase Activity in Human Breast Tumors*

1983 • 134 citations

Breast Cancer and the Role of Cytokines in Regulating Estrogen Synthesis: An Emerging Hypothesis

1997 • 131 citations

Use of alternative promoters to express the aromatase cytochrome P450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients

1996 • 116 citations

Overexpression of int-5/aromatase in mammary glands of transgenic mice results in the induction of hyperplasia and nuclear abnormalities.

1996 • 113 citations

Presence of alternatively spliced transcripts of aromatase gene in human breast cancer.

1996 • 109 citations

Regulation of Aromatase Activity of Stromal Cells Derived from Human Adipose Tissue*

1982 • 108 citations

Regulation of aromatase expression in human tissues

1994 • 107 citations

Aromatase Activity and Expression in Breast Cancer and Benign Breast Tissue Stromal Cells

1997 • 106 citations

Transcriptional regulation of CYP19 gene (aromatase) expression in adipose stromal cells in primary culture

1997 • 105 citations

Intratumoral Aromatase in Human Breast, Endometrial, and Ovarian Malignancies

1998 • 104 citations

Characterization of epithelial phenotypes in mortal and immortal human breast cells

1992 • 97 citations

Expression of the gene encoding aromatase cytochrome P450 (CYP19) in fetal tissues.

1994 • 95 citations

Growth Factors Suppress and Phorbol Esters Potentiate the Action of Dibutyryl Adenosine 3′,5′-Monophosphate to Stimulate Aromatase Activity of Human Adipose Stromal Cells*

1986 • 93 citations

Characterization of the sequences of the human CYP19 (aromatase) gene that mediate regulation by glucocorticoids in adipose stromal cells and fetal hepatocytes

1995 • 85 citations

Determination of aromatase cytochrome P450 messenger ribonucleic acid in human breast tissue by competitive polymerase chain reaction amplification.

1992 • 73 citations

Oestrogen formation from androstenedione in human bone

1995 • 72 citations

Expression of aromatase protein and messenger ribonucleic acid in tumor epithelial cells and evidence of functional significance of locally produced estrogen in human breast cancers

1996 • 70 citations

Expression of the gene encoding aromatase cytochrome P450 (CYP19) in fetal tissues

1994 • 70 citations

Regulation of vimentin expression in cultured human mammary epithelial cells

1990 • 68 citations

Effect of androstenedione on growth of untransfected and aromatase-transfected MCF-7 cells in culture

1993 • 65 citations

Alternative promotion of aromatase P-450 expression in the human placenta

1992 • 64 citations

Differential regulation of breast tumor cell proliferation by stromal fibroblasts of various breast tissue sources

1996 • 58 citations

Stromal spindle cells contain aromatase in human breast tumors

1994 • 58 citations

Breast Cancer and the Role of Cytokines in Regulating Estrogen Synthesis: An Emerging Hypothesis

1997 • 57 citations

Steroid and growth factor modulation of aromatase activity in MCF7 and T47D breast carcinoma cell lines.

1992 • 54 citations

Molecular cloning of a cDNA showing alternative splicing of the 5′‐untranslated sequence of mRNA for human aromatase P‐450

1993 • 54 citations

Phenotypic heterogeneity in breast fibroblasts: Functional anomaly in fibroblasts from histologically normal tissue adjacent to carcinoma

1994 • 50 citations

Control of aromatase in breast cancer cells and its importance for tumor growth

1993 • 49 citations

Identification of a Promoter That Controls Aromatase Expression in Human Breast Cancer and Adipose Stromal Cells

1996 • 46 citations

Gene regulation studies of aromatase expression in breast cancer and adipose stromal cells

1997 • 46 citations

Presence of alternatively spliced transcripts of aromatase gene in human breast cancer

1996 • 43 citations

Myofibroblast and concurrent ED-B fibronectin phenotype in human stromal cells cultured from non-malignant and malignant breast tissue

1994 • 43 citations

Characterization of a Silencer Element in the Human Aromatase Gene

1998 • 35 citations

Determination of aromatase cytochrome P450 messenger ribonucleic acid in human breast tissue by competitive polymerase chain reaction amplification

1992 • 30 citations

Aromatase activity in human skin fibroblasts grown in cell culture

1987 • 17 citations

Local aromatase activity in human breast tissues

1993 • 17 citations

The overexpression of int-5/aromatase, a novel MMTV integration locus gene, is responsible for D2 mammary tumor cell proliferation

1995 • 16 citations

Gene Regulation Studies of Aromatase Expression in Breast Cancer and Adipose Stromal Cells

1997 • 7 citations

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