Gene regulation studies of aromatase expression in breast cancer and adipose stromal cells

Expression of Transforming Growth Factor α and its Messenger Ribonucleic Acid in Human Breast Cancer: Its Regulation by Estrogen and its Possible Functional Significance

1988 • 440 citations

Concentrations of estrone, estradiol, and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and postmenopausal breast cancer patients.

1996 • 410 citations

Tissue-specific expression of the human aromatase cytochrome P-450 gene by alternative use of multiple exons 1 and promoters, and switching of tissue-specific exons 1 in carcinogenesis.

1993 • 361 citations

A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription.

1993 • 337 citations

Tissue-specific and hormonally controlled alternative promoters regulate aromatase cytochrome P450 gene expression in human adipose tissue.

1993 • 303 citations

Autocrine and paracrine growth regulation of human breast cancer

1986 • 293 citations

Tissue-Specific Promoters Regulate Aromatase Cytochrome P450 Gene Expression in Human Ovary and Fetal Tissues

1991 • 257 citations

Activity of two different silencer elements of the chicken lysozyme gene can be compensated by enhancer elements.

1987 • 226 citations

Concentrations of estrone, estradiol, and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and postmenopausal breast cancer patients

1996 • 217 citations

Stable expression of human aromatase complementary DNA in mammalian cells: a useful system for aromatase inhibitor screening.

1990 • 205 citations

Tissue-specific expression of human P-450AROM. The promoter responsible for expression in adipose tissue is different from that utilized in placenta

1991 • 178 citations

Immunolocalization of aromatase and other steroidogenic enzymes in human breast disorders

1994 • 172 citations

A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription [published erratum appears in J Clin Endocrinol Metab 1994 Feb;78(2):494]

1993 • 172 citations

Detection of intratumoral aromatase in breast carcinomas. An immunohistochemical study with clinicopathologic correlation.

1992 • 162 citations

A new nude mouse model for postmenopausal breast cancer using MCF-7 cells transfected with the human aromatase gene.

1994 • 155 citations

Stromal spindle cells contain aromatase in human breast tumors.

1994 • 148 citations

Autocrine and paracrine growth regulation of human breast cancer

1986 • 135 citations

Aromatase gene expression and its exon I usage in human breast tumors. Detection of aromatase messenger RNA by reverse transcription-polymerase chain reaction

1996 • 134 citations

A unique aromatase (P-450arom) mRNA formed by alternative use of tissue-specific exons 1 in human skin fibroblasts

1992 • 101 citations

Expression of the gene encoding aromatase cytochrome P450 (CYP19) in fetal tissues.

1994 • 95 citations

Effect of androstenedione on growth of untransfected and aromatase-transfected MCF-7 cells in culture

1993 • 65 citations

Identification of a Promoter That Controls Aromatase Expression in Human Breast Cancer and Adipose Stromal Cells

1996 • 46 citations

Contribution of aromatase to the deoxyribonucleic acid synthesis of MCF-7 human breast cancer cells and its suppression by aromatase inhibitors

1992 • 41 citations

Aromatase gene is amplified in MCF-7 human breast cancer cells

1993 • 39 citations

Identification of a promoter and a silencer at the 3'-end of the first intron of the human aromatase gene.

1992 • 26 citations