Malignant breast epithelium selects for insulin-like growth factor II expression in breast stroma: evidence for paracrine function.

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Induction of angiogenesis during the transition from hyperplasia to neoplasia

1989 • 1,912 citations

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting

1990 • 1,650 citations

Insulin-like growth factors and cancer

1992 • 622 citations

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts.

1994 • 527 citations

Analysis of Insulin-Like Growth Factor I Gene Expression in Malignancy: Evidence for a Paracrine Role in Human Breast Cancer

1989 • 403 citations

Treatment and Prevention of Rat Glioblastoma by Immunogenic C6 Cells Expressing Antisense Insulin-Like Growth Factor I RNA

1993 • 328 citations

Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors.

1994 • 310 citations

Somatomedin-C receptors and growth effects in human breast cells maintained in long-term tissue culture.

1984 • 256 citations

Insulin-Like Growth Factor-ll (IGF-II): A Potential Autocrine/Paracrine Growth Factor for Human Breast Cancer Acting via the IGF-I Receptor

1989 • 248 citations

Insulin-like growth factor II mRNA expression in human breast cancer.

1988 • 245 citations

Stromelysin 3 belongs to a subgroup of proteinases expressed in breast carcinoma fibroblastic cells and possibly implicated in tumor progression.

1993 • 209 citations

Growth factor messenger RNA expression by human breast fibroblasts from benign and malignant lesions.

1991 • 204 citations

Antisense-mediated reduction in insulin-like growth factor-I receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma.

1994 • 170 citations

Constitutive expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor abrogates all requirements for exogenous growth factors.

1992 • 159 citations

Purification of the migration stimulating factor produced by fetal and breast cancer patient fibroblasts.

1989 • 153 citations

Frequent expression of growth factors for mesenchymal cells in human mammary carcinoma cell lines.

1987 • 151 citations

Foetal and cancer patient fibroblasts produce an autocrine migrationstimulating factor not made by normal adult cells

1988 • 142 citations

Receptor binding and growth-promoting activity of insulin-like growth factors in human breast cancer cells (T-47D) in culture.

1984 • 139 citations

Insulin-like growth factor-II overexpression in MCF-7 cells induces phenotypic changes associated with malignant progression.

1992 • 120 citations

Intact and amino-terminally shortened forms of insulin-like growth factor I induce mammary gland differentiation and development.

1992 • 114 citations

Roles of insulinlike growth factor 1 (IGF-1) and the IGF-1 receptor in epidermal growth factor-stimulated growth of 3T3 cells.

1992 • 110 citations

Mitogenicity of human fibroblasts in vivo for human breast cancer cells

1987 • 89 citations

Skin fibroblasts obtained from cancer patients display foetal-like migratory behaviour on collagen gels

1985 • 75 citations

Abnormal properties of skin fibroblasts from patients with breast cancer

1984 • 75 citations

Autocrine production of insulin-like growth factor II using an inducible expression system results in reduced estrogen sensitivity of MCF-7 human breast cancer cells.

1991 • 57 citations

Hormonal regulation of insulin-like growth factor II and insulin-like growth factor binding protein expression by breast cancer cells in vivo: evidence for stromal epithelial interactions.

1994 • 51 citations

Fibroblast‐mediated differentiation in human breast carcinoma cells (MCF‐7) grown as nodules IN VITRO

1994 • 45 citations

Regulation of insulin‐like growth factor‐II expression and its role in autocrine growth of human neuroblastoma cells

1993 • 44 citations

Myofibroblast and concurrent ED-B fibronectin phenotype in human stromal cells cultured from non-malignant and malignant breast tissue

1994 • 43 citations

Mapping of brain insulin and insulin-like growth factor receptor gene expression by in situ hybridization

1992 • 34 citations

Platelet-derived growth factor-induced expression of messenger RNA for the proliferating cell nuclear antigen requires a functional receptor for the insulin-like growth factor I.

1994 • 32 citations

Fibroblast stimulation of breast cancer cell growth in a serum-free system

1993 • 31 citations

Stromal-epithelial interactions in breast cancer

1991 • 31 citations