Genetic evidence for base pairing between U2 and U6 snRNA in mammalian mRNA splicing

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

U2 as well as U1 small nuclear ribonucleoproteins are involved in premessenger RNA splicing

1985 • 568 citations

SPLICEOSOMAL snRNAs

1988 • 463 citations

Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for Pre-mRNA splicing in vitro

1985 • 442 citations

Spliceosome assembly in yeast.

1987 • 402 citations

Crystal structure of yeast phenylalanine transfer RNA

1978 • 375 citations

Requirement of the RNA helicase-like protein PRP22 for release of messenger RNA from spliceosomes

1991 • 354 citations

PRP16 is an RNA-dependent ATPase that interacts transiently with the spliceosome

1991 • 329 citations

Mammalian pre-mRNA branch site selection by U2 snRNP involves base pairing.

1989 • 314 citations

A compensatory base change in human U2 snRNA can suppress a branch site mutation.

1989 • 284 citations

Electrophoresis of ribonucleoproteins reveals an ordered assembly pathway of yeast splicing complexes

1986 • 283 citations

Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein.

1988 • 188 citations

Multiple roles for U6 snRNA in the splicing pathway.

1990 • 179 citations

Base pairing between U2 and U6 snRNAs is necessary for splicing of a mammalian pre-mRNA

1991 • 172 citations

Two Domains of Yeast U6 Small Nuclear RNA Required for Both Steps of Nuclear Precursor Messenger RNA Splicing

1990 • 171 citations

Evidence for base-pairing between mammalian U2 and U6 small nuclear ribonucleoprotein particles.

1990 • 171 citations

Antisense probing of the human U4U6 snRNP with biotinylated 2′-OMe RNA oligonucleotides

1989 • 169 citations

Upstream elements required for efficient transcription of a human U6 RNA gene resemble those of U1 and U2 genes even though a different polymerase is used.

1988 • 157 citations

In vitro assembly of yeast U6 snRNP: a functional assay.

1989 • 134 citations

Domains of U4 and U6 snRNAs required for snRNP assembly and splicing complementation in Xenopus oocytes.

1990 • 127 citations

Probing the structure and function of U2 snRNP with antisense oligonucleotides made of 2′-OMe RNA

1989 • 115 citations

Functional analysis of mutant Xenopus U2 snRNAs

1989 • 103 citations

Different Small Nuclear Ribonucleoprotein Particles Are Involved in Different Steps of Splicing Complex Formation

1987 • 68 citations

U2 snRNA sequences that bind U2-specific proteins are dispensable for the function of U2 snRNP in splicing.

1989 • 64 citations

Human U2 snRNA can function in pre-mRNA splicing in yeast

1990 • 50 citations

Genetic analysis of the role of human U1 snRNA in mRNA splicing: I. Effect of mutations in the highly conserved stem-loop I of U1.

1989 • 27 citations