1995 Deichmann Lecture—p53 tumor suppressor gene: At the crossroads of molecular carcinogenesis, molecular epidemiology and cancer risk assessment

p53 Mutations in Human Cancers

1991 • 8,133 citations

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

1995 • 2,767 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.

1991 • 1,946 citations

p53 function and dysfunction

1992 • 1,918 citations

Tumor Suppressor Genes

1991 • 1,784 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

1994 • 1,542 citations

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1991 • 1,525 citations

Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

1991 • 1,418 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Clinical Implications of the p53 Tumor-Suppressor Gene

1993 • 1,341 citations

DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors

1991 • 1,223 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

DNA damage and mutation in human cells exposed to nitric oxide in vitro.

1992 • 980 citations

Gain of function mutations in p53

1993 • 876 citations

p53: oncogene or anti-oncogene?

1990 • 812 citations

DNA Repair Helicase: a Component of BTF2 (TFIIH) Basic Transcription Factor

1993 • 795 citations

Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells

1992 • 784 citations

5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

1990 • 643 citations

p53 modulation of TFIIH–associated nucleotide excision repair activity

1995 • 555 citations

Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes.

1993 • 482 citations

High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene.

1989 • 383 citations

Slow Repair of Pyrimidine Dimers at p53 Mutation Hotspots in Skin Cancer

1994 • 301 citations

High frequency mutagenesis by a DNA methyltransferase

1992 • 259 citations

Gene specific DNA repair

1991 • 181 citations

Science and Judgement in Risk Assessment

1995 • 172 citations

Preferential repair and strand-specific repair of benzo[a]pyrene diol epoxide adducts in the HPRT gene of diploid human fibroblasts.

1992 • 130 citations

p53 mutations in lung cancers from non-smoking atomic-bomb survivors

1993 • 118 citations

Hepatocarcinoma-specific mutant p53-249ser induces mitotic activity but has no effect on transforming growth factor beta 1-mediated apoptosis.

1994 • 97 citations

DNA strand bias in the repair of the p53 gene in normal human and xeroderma pigmentosum group C fibroblasts.

1993 • 65 citations

Molecular carcinogenesis in humans and rodents.

1992 • 17 citations