Differentiation and cell division in the mammalian thymus

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

A cell-surface molecule involved in organ-specific homing of lymphocytes

1983 • 1,515 citations

An alternative pathway of T-cell activation: A functional role for the 50 kd T11 sheep erythrocyte receptor protein

1984 • 1,132 citations

T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes

1982 • 1,026 citations

Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex.

1983 • 833 citations

Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester

1985 • 753 citations

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.

1985 • 742 citations

Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells

1985 • 613 citations

Thymus cell migration: Quantitative aspects of cellular traffic from the thymus to the periphery in mice

1980 • 551 citations

Developmental regulation of T-cell receptor gene expression

1985 • 522 citations

Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway.

1984 • 506 citations

Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line.

1984 • 504 citations

Interleukin 2

1984 • 497 citations

Expression of interleukin 2 receptors on activated human B cells.

1984 • 488 citations

A common sequence of calcium and pH signals in the mitogenic stimulation of eukaryotic cells

1985 • 456 citations

Interleukin 2 regulates its own receptors.

1985 • 414 citations

Transcripts from the Cellular Homologs of Retroviral Oncogenes: Distribution Among Chicken Tissues

1982 • 406 citations

Structure, organization, and somatic rearrangement of T cell gamma genes

1985 • 395 citations

Evidence implicating L3T4 in class II MHC antigen reactivity; monoclonal antibody GK1.5 (anti-L3T4a) blocks class II MHC antigen-specific proliferation, release of lymphokines, and binding by cloned murine helper T lymphocyte lines.

1983 • 377 citations

The Major Histocompatibility Complex-Restricted Antigen Receptor on T Cells

1984 • 368 citations

Heterogeneity of Natural Killer Cells

1984 • 368 citations

THYMUS CELL MIGRATION

1967 • 356 citations

T Cell Development in the Adult Murine Thymus: Changes in the Expression of the Surface Antigens Ly2, L3T4 and B2A2 during Development from Early Precursor Cells to Emigrants

1984 • 344 citations

The major histocompatibility complex-restricted antigen receptor on T cells. II. Role of the L3T4 product.

1983 • 325 citations

Thymic nurse cells—Ia-bearing epithelium involved in T-lymphocyte differentiation?

1980 • 269 citations

Characterization of the activation of Na+/H+ exchange in lymphocytes by phorbol esters: change in cytoplasmic pH dependence of the antiport.

1985 • 254 citations

Ontogeny of the T-cell antigen receptor within the thymus

1985 • 250 citations

Precursors of T cell growth factor producing cells in the thymus: ontogeny, frequency, and quantitative recovery in a subpopulation of phenotypically mature thymocytes defined by monoclonal antibody GK-1.5.

1983 • 237 citations

Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function.

1981 • 234 citations

The Human T-Cell Receptor

1984 • 232 citations

Cytolysis by H-2-specific T killer cells. Assembly of tubular complexes on target membranes.

1983 • 229 citations

Monoclonal antibodies to stromal cell types of the mouse thymus

1984 • 228 citations

Regulation of interleukin 2 receptor expression: effects of phorbol diester, phospholipase C, and reexposure to lectin or antigen.

1984 • 227 citations

Mitogens increase phosphorylation of phosphoinositides in thymocytes

1984 • 223 citations

Expression and function of interleukin-2 receptors on immature thymocytes

1985 • 217 citations

Effect of recombinant IL 2 and gamma-IFN on proliferation and differentiation of human B cells.

1985 • 216 citations

The major histocompatibility complex-restricted antigen receptor on T cells: Distribution on thymus and peripheral T cells

1984 • 210 citations

Is terminal deoxynucleotidyl transferase a somatic mutagen in lymphocytes?

1974 • 205 citations

Activation of a human T cell line: a two-stimulus requirement in the pretranslational events involved in the coordinate expression of interleukin 2 and gamma-interferon genes.

1985 • 203 citations

Abelson murine leukemia virus-induced tumors elicit antibodies against a host cell protein, P50

1980 • 200 citations

Rearrangement of T-cell receptor beta-chain genes during T-cell development.

1985 • 200 citations

Phytohaemagglutinin activation of T cells through the sheep red blood cell receptor

1985 • 200 citations

Structure of the human interleukin 2 gene.

1983 • 197 citations

The T3 complex on human T lymphocytes involves four structurally distinct glycoproteins.

1983 • 194 citations

The differentiation of T lymphocytes

1974 • 185 citations

Cell Surface Antigen Expression on Thymocytes: Development and Phenotypic Differentiation of Intrathymic Subsets

1984 • 179 citations

Thymocyte subpopulations: an experimental review, including flow cytometric cross-correlations between the major murine thymocyte markers.

1983 • 178 citations

Activation of human thymocytes via the 50KD T11 sheep erythrocyte binding protein induces the expression of interleukin 2 receptors on both T3+ and T3- populations.

1985 • 170 citations

Increase in cytosolic free calcium concentration is an intracellular messenger for the production of interleukin 2 but not for expression of the interleukin 2 receptor.

1985 • 164 citations

Hematopoietic thymocyte precursors. I. Assay and kinetics of the appearance of progeny.

1976 • 154 citations

Phenotypic characterization and ontogeny of mesodermal-derived and endocrine epithelial components of the human thymic microenvironment.

1984 • 154 citations

T-cell specificity for H–2 and Ir gene phenotype correlates with the phenotype of thymic antigen-presenting cells

1980 • 153 citations

Relationship of cell cycle to recovery of IL 2 activity from human mononuclear cells, human and mouse T cell lines.

1981 • 148 citations

Bone marrow cells give rise to distinct cell clones within the thymus

1984 • 146 citations

Control of biologically active interleukin 2 messenger RNA formation in induced human lymphocytes.

1984 • 141 citations

Purine and pyrimidine metabolism in human T lymphocytes. Regulation of deoxyribonucleotide metabolism.

1983 • 141 citations

Expression of a proto-oncogene (proto-myb) in hemopoietic tissues of mice.

1984 • 140 citations

Expression of genes of the T-cell antigen receptor complex in precursor thymocytes

1985 • 135 citations

Comparison of T3-associated 49- and 43-kilodalton cell surface molecules on individual human T-cell clones: evidence for peptide variability in T-cell receptor structures.

1983 • 133 citations

Differentiation of thymocytes in fetal organ culture: analysis of phenotypic changes accompanying the appearance of cytolytic and interleukin 2-producing cells.

1984 • 131 citations

The differentiation of T lymphocytes. V. Evidence for intrathymic death of most thymocytes.

1979 • 126 citations

Nude Mice in Immunology

2015 • 114 citations

Control of the Balb/c‐3T3 cell cycle by nutrients and serum factors: Analysis using platelet‐derived growth factor and platelet‐poor plasma

1979 • 114 citations

Phenotypic and functional properties of murine thymocytes. I. Precursors of cytolytic T lymphocytes and interleukin 2-producing cells are all contained within a subpopulation of "mature" thymocytes as analyzed by monoclonal antibodies and flow microfluorometry

1982 • 114 citations

T-cell growth factor: complete nucleotide sequence and organization of the gene in normal and malignant cells.

1984 • 113 citations

Lymphoepithelial interactions in the mouse thymus: phenotypic and kinetic studies on thymic nurse cells.

1982 • 109 citations

ON THE SPARSE SEEDING OF BONE MARROW AND THYMUS IN RADIATION CHIMAERAS

1975 • 103 citations

A homing receptor-bearing cortical thymocyte subset: Implications for thymus cell migration and the nature of cortisone-resistant thymocytes

1984 • 102 citations

Renewal and fate in the mammalian thymus: Mechanisms and inferences of thymocytokinetics

1972 • 99 citations

The T3 complex on human thymus‐derived lymphocytes contains two different subunits of 20 kDa

1983 • 99 citations

Distribution of terminal deoxynucleotidyl transferase and purine degradative and synthetic enzymes in subpopulations of human thymocytes.

1982 • 94 citations

In vitro maturation of immature thymocytes into immunocompetent T cells in the absence of direct thymic influence

1978 • 92 citations

Thymic Regeneration after Lethal Irradiation: Evidence for an Intra-Thymic Radioresistant T Cell Precursor

1975 • 92 citations

Evidence that the Pgp-1 glycoprotein is expressed on thymus-homing progenitor cells of the thymus

1985 • 88 citations

Hematopoietic thymocyte precursors: II. Properties of the precursors.

1977 • 88 citations

The functional capabilities of cells leaving the thymus.

1984 • 84 citations

A molecular basis for thymic selection: regulation of T11 induced thymocyte expansion by the T3-Ti antigen/MHC receptor pathway

1985 • 84 citations

Immunohistology of lymphoid and non‐lymphoid cells in the thymus in relation to T lymphocyte differentiation

1984 • 83 citations

An in vivo assay for thymus-homing bone marrow cells

1981 • 79 citations

Recognition and Regulation in Cell-Mediated Immunity

1985 • 79 citations

The differentiation of murine thymocytes in vivo and in vitro.

1978 • 76 citations

Clonal proliferation unlinked to terminal deoxynucleotidyl transferase synthesis in thymocytes of young mice.

1983 • 74 citations

Lyt-2-/Lyt 3- variants of a cloned cytolytic T cell line lack an antigen receptor functional in cytolysis.

1981 • 74 citations

Hematopoietic thymocyte precursors

1977 • 69 citations

Correlation of Lymphocyte Transformation and Morphology in the Human Fetal Thymus

1970 • 68 citations

The human thymic microenvironment: cortical thymic epithelium is an antigenically distinct region of the thymic microenvironment.

1984 • 67 citations

Lyt markers on thymus cell migrants

1978 • 67 citations

Embryology of the Lymphoid System

2015 • 57 citations

DIFFERENCES IN REUTILIZATION OF THYMIDINE IN HEMOPOIETIC AND LYMPHOPOIETIC TISSUES OF THE NORMAL MOUSE

1973 • 55 citations

Characteristics of thymus-homing bone marrow cells.

1983 • 53 citations

Cell cycle regulation of cloned cytolytic T cells by T cell growth factor: analysis by flow microfluorometry.

1982 • 51 citations

Post‐Irradiation Thymocyte Regeneration After Bone Marrow Transplantation I. Regeneration and Quantification of Thymocyte Progenitor Cells In the Bone Marrow

1981 • 47 citations

Development of cytolytic T lymphocyte precursors in organ-cultured mouse embryonic thymus rudiments.

1982 • 46 citations

Intrathymic T cell differentiation in radiation bone marrow chimeras and its role in T cell emigration to the spleen. An immunohistochemical study.

1985 • 45 citations

The immunocompetence of murine stromal cell-associated thymocytes.

1984 • 42 citations

Proliferation of thymic stem cells with and without receptors for interleukin 2. Implications for intrathymic antigen recognition.

1985 • 41 citations

Detection and localization by the monoclonal antiinterleukin 2 receptor antibody AMT‐13 of IL 2 receptor‐bearing cells in the developing thymus of the mouse embryo and in the thymus of cortisone‐treated mice

1984 • 39 citations

Fate of thymocytes: studies with 125I-iododeoxyuridine and 3H-thymidine in mice.

1977 • 36 citations

Repopulation of the mouse thymus after sublethal fission neutron irradiation. I. Sequential appearance of thymocyte subpopulations.

1985 • 35 citations

A specific biosynthetic marker for immature thymic lymphoblasts. Active synthesis of thymus-leukemia antigen restricted to proliferating cells

1982 • 33 citations

Phenotypic and functional properties of murine thymocytes. II. Quantitation of host- and donor-derived cytolytic T lymphocyte precursors in regenerating radiation bone marrow chimeras.

1982 • 33 citations

Immunohistochemical localization of host and donor-derived cells in the regenerating thymus of radiation bone marrow chimeras.

1984 • 31 citations

Ontogeny of Cell-Mediated Cytotoxicity: Induction of CTL in Early Postnatal Thymocytes

1979 • 30 citations

CYTODYNAMICS IN THE THYMUS OF YOUNG ADULT MICE:

1976 • 30 citations

Intrathymic differentiation: Thymocyte heterogeneity and the characterization of early t-cell precursors

1985 • 29 citations

The Intrathymic Environment

1973 • 29 citations

FREQUENCY OF ALLOREACTIVE CYTOTOXIC T CELL PRECURSORS IN THE MOUSE THYMUS AND SPLEEN DURING ONTOGENY

1979 • 28 citations

T cell ontogeny. Organ location of maturing populations as defined by surface antigen markers is similar in neonates and adults.

1981 • 28 citations

High-level secretion of interleukin 2 by a subset of proliferating thymic lymphoblasts.

1984 • 25 citations

Intrathymic lymphopoiesis: stromal cell-associated proliferation of T cells is independent of lymphocyte genotype.

1984 • 25 citations

Elaboration of a Model for the Formation of Lymphocytes in the Thymic Cortex of Young Adult Rats

1965 • 25 citations

Mechanism of T-cell lymphomagenesis: transformation of growth-factor-dependent T-lymphoblastoma cells to growth-factor-independent T-lymphoma cells.

1984 • 19 citations

Adult and pre-adult thymectomy of mice: contrasting effects on immune responsiveness, and on numbers of mitogen-responsive and Thy-1+ lymphocytes.

1979 • 15 citations

The Ly phenotype of functional medullary thymocytes.

1983 • 12 citations

Ontogeny of proliferative and cytotoxic responses to interleukin 2 and concanavalin A in murine fetal thymus.

1985 • 10 citations

The Structure of the Thymus

1966 • 9 citations

Virus-immune and alloreactive response characteristics of thymocytes and spleen cells from young mice.

1981 • 8 citations

Deleted Work

1955 • 0 citations