Cell Surface Antigen Expression on Thymocytes: Development and Phenotypic Differentiation of Intrathymic Subsets

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

1983 • 1,307 citations

Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.

1975 • 1,105 citations

Functional subclasses of T lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity.

1975 • 758 citations

Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins

1984 • 719 citations

Current concepts of the immunological function of the thymus.

1967 • 577 citations

T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views.

1980 • 574 citations

Thymus cell migration: Quantitative aspects of cellular traffic from the thymus to the periphery in mice

1980 • 551 citations

Separation of mouse thymocytes into two subpopulations by the use of peanut agglutinin

1976 • 513 citations

Effect of Hormones on Lymphatic Tissue

1952 • 512 citations

Dependence of Thymus Development on Derivatives of the Neural Crest

1984 • 463 citations

SOME ASPECTS OF NORMAL AND ABNORMAL CELL SURFACE GENETICS

1969 • 415 citations

Regulation of Cellular and Humoral Immune Responses by T-cell Subclasses

1977 • 368 citations

THYMUS CELL MIGRATION

1967 • 356 citations

Thymic nurse cells. Lymphoepithelial cell complexes in murine thymuses: morphological and serological characterization

1980 • 343 citations

Intrathymic and Extrathymic T Cell Maturation

1978 • 327 citations

A rat anti-mouse T4 monoclonal antibody (H129.19) inhibits the proliferation of Ia-reactive T cell clones and delineates two phenotypically distinct (T4+, Lyt-2,3-, and T4-, Lyt-2,3+) subsets among anti-Ia cytolytic T cell clones.

1984 • 308 citations

Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse

1968 • 289 citations

Thymic nurse cells—Ia-bearing epithelium involved in T-lymphocyte differentiation?

1980 • 269 citations

The lymphoreticular system in triggering virus plus self-specific cytotoxic T cells: evidence for T help.

1978 • 268 citations

Evidence for a small pool of immunocompetent cells in the mouse thymus

1969 • 263 citations

The Influence of Thymus H-2 Antigens on the Specificity of Maturing Killer and Helper Cells

1978 • 257 citations

Characteristics of the immunocompetent cells in the mouse thymus: Cell population changes during cortisone-induced atrophy and subsequent regeneration

1970 • 247 citations

Precursors of T cell growth factor producing cells in the thymus: ontogeny, frequency, and quantitative recovery in a subpopulation of phenotypically mature thymocytes defined by monoclonal antibody GK-1.5.

1983 • 237 citations

Expression of Lyt-1 by a subset of B lymphocytes.

1982 • 204 citations

THYMUS CELL MATURATION

1973 • 202 citations

STUDIES ON THE DIFFERENTIATION OF THYMUS-DERIVED LYMPHOCYTES

1970 • 198 citations

Bone marrow origin of Ia-positive cells in the medulla rat thymus.

1981 • 197 citations

HORMONAL CONTROL OF LYMPHATIC STRUCTURE AND FUNCTION*

1964 • 193 citations

Expression of MHC Antigens by Mouse Thymic Dendritic Cells

1979 • 191 citations

Ly antigens as markers for functionally distinct subpopulations of thymus-derived lymphocytes of the mouse

1975 • 191 citations

The differentiation of T lymphocytes

1974 • 185 citations

Thymocyte subpopulations: an experimental review, including flow cytometric cross-correlations between the major murine thymocyte markers.

1983 • 178 citations

Demonstration of a cyclic renewal of the lymphocyte precursor cells in the quail thymus during embryonic and perinatal life.

1982 • 172 citations

Hydrocortisne resistance of graft vs host activity in mouse thymus, spleen and bone marrow.

1970 • 165 citations

THE PATTERN OF LYMPHOPOIESIS IN THE MOUSE THYMUS AFTER CORTISONE ADMINISTRATION OR ADRENALECTOMY

1963 • 155 citations

Hematopoietic thymocyte precursors. I. Assay and kinetics of the appearance of progeny.

1976 • 154 citations

Peanut agglutinin. I. A new tool for studying T lymphocyte subpopulations.

1978 • 153 citations

T-cell specificity for H–2 and Ir gene phenotype correlates with the phenotype of thymic antigen-presenting cells

1980 • 153 citations

Bone marrow cells give rise to distinct cell clones within the thymus

1984 • 146 citations

IA antigens and antigen-presenting function of thymic macrophages.

1980 • 141 citations

Fluorescence analysis and anatomic distribution of mouse T lymphocyte subsets defined by monoclonal antibodies to the antigens Thy-1, Lyt-1, Lyt-2, and T-200.

1981 • 141 citations

Successful transplantation across major histocompatibility barrier of deoxyguanosine-treated embryonic thymus expressing class II antigens

1984 • 138 citations

Cell surface appearance of unexpected host MHC determinants on thymocytes from radiation bone marrow chimeras.

1981 • 135 citations

The role of H-2 linked genes in helper T-cell function. IV. Importance of T-cell genotype and host environment in I-region and Ir gene expression.

1978 • 134 citations

Evidence for a small pool of immunocompetent cells in the mouse thymus. Its role in the humoral antibody response against sheep erythrocytes, bovine serum albumin, ovalbumin and the NIP determinant

1970 • 128 citations

Distribution of H-2 microenvironments in the mouse thymus. Immunoelectron microscopic identification of I-A and H-2K bearing cells.

1980 • 127 citations

Thymus cell maturation

1975 • 127 citations

The differentiation of T lymphocytes. V. Evidence for intrathymic death of most thymocytes.

1979 • 126 citations

An Lyt differentiated thymocyte subpopulation detected by flow microfluorometry

1979 • 122 citations

THE INFLOW OF BONE MARROW CELLS TO THE THYMUS: STUDIES WITH PART‐BODY IRRADIATED MICE INJECTED WITH CHROMOSOME‐MARKED BONE MARROW AND SUBJECTED TO ANTIGENIC STIMULATION

1966 • 120 citations

Expression of Lyt-1 antigen on certain murine B cell lymphomas.

1981 • 120 citations

Hydrocortisone Resistance of Graft vs Host Activity in Mouse Thymus, Spleen and Bone Marrow

1970 • 118 citations

Phenotypic and functional properties of murine thymocytes. I. Precursors of cytolytic T lymphocytes and interleukin 2-producing cells are all contained within a subpopulation of "mature" thymocytes as analyzed by monoclonal antibodies and flow microfluorometry

1982 • 114 citations

Ly-C: a third locus specifying alloantigens expressed only on thymocytes and lymphocytes.

1971 • 113 citations

Lymphokines: their role in lymphocyte responses. Properties of interleukin 1.

1982 • 113 citations

Independent differentiative pathways of Ly1 and Ly23 subclasses of T cells. Experimental production of mice deprived of selected T-cell subclasses.

1976 • 102 citations

Renewal and fate in the mammalian thymus: Mechanisms and inferences of thymocytokinetics

1972 • 99 citations

In vitro maturation of immature thymocytes into immunocompetent T cells in the absence of direct thymic influence

1978 • 92 citations

Antigens of the Thymus (Part 1 of 3)

1972 • 91 citations

Peanut Agglutinin

1978 • 91 citations

The glycolipid asialo GM1 as a new differentiation antigen of fetal thymocytes.

1980 • 90 citations

Immunocompetent Cells among Mouse Thymocytes: A Minor Population

1971 • 89 citations

Preparative nonlytic separation of Lyt2⁺ and Lyt2⁻ T lymphocytes, functional analyses of the separated cells and demonstration of synergy in graft‐vs.‐host reaction of Lyt2⁺ and Lyt2⁻ cells

1981 • 84 citations

Immunohistology of lymphoid and non‐lymphoid cells in the thymus in relation to T lymphocyte differentiation

1984 • 83 citations

Lymphoid stem cell homing to the early thymic primordium of the avian embryo

1980 • 83 citations

Evidence for Subpopulation of Mature Lymphocytes within Mouse Thymus

1971 • 78 citations

Binding of peanut lectin to thymic cortex and germinal centres of lymphoid tissue.

1981 • 77 citations

Lyt 1+23− cells appear in the thymus before Lyt 123+ cells

1981 • 77 citations

LY-C

1971 • 76 citations

Early development of the T cell repertoire. In vivo treatment of neonatal mice with anti-Ia antibodies interferes with differentiation of I-restricted T cells but not K/D-restricted T cells.

1983 • 74 citations

Flow microfluorometric analysis of mouse thymus development in vivo and in vitro

1983 • 71 citations

Hematopoietic thymocyte precursors

1977 • 69 citations

Thymus cell migration: cells migrating from thymus to peripheral lymphoid organs have a "mature" phenotype.

1982 • 69 citations

Lyt markers on thymus cell migrants

1978 • 67 citations

Expression of Ly 1, Ly 2, Thy 1, and TL differentiation antigens on mouse T-cell tumors.

1978 • 66 citations

IMMUNOLOGIC PROPERTIES OF MOUSE THYMUS CELLS

1972 • 66 citations

Detection of Thy‐1, T‐200, Lyt‐1 and Lyt‐2‐bearing cells in the developing lymphoid organs of the mouse embryo in vivo and in vitro

1982 • 64 citations

The H-2 phenotype of the thymus dictates the self-specificity expressed by thymic but not splenic cytotoxic T lymphocyte precursors in thymus-engrafted nude mice.

1981 • 61 citations

Lymphocyte differentiation and major histocompatibility complex antigen expression in the embryonic thymus

1980 • 61 citations

Differentiation in vitro of Lyt 2+ thymocytes from embryonic Lyt 2− precursors

1983 • 59 citations

Differential binding of fluorescein-labeled lectins to mouse thymocytes: subsets revealed by flow microfluorometry.

1980 • 58 citations

T cell maturation: thymocyte and thymus migrant subpopulations defined with monoclonal antibodies to the antigens Lyt-1, Lyt-2, and ThB1.

1980 • 58 citations

Distinct Effects of Thymic Epithelial Culture Supernatants on T Cell Properties of Mouse Thymocytes Separated by the Use of Peanut Agglutinin

1979 • 56 citations

Cells bearing Ia antigens in the murine thymus. An ultrastructural study.

1983 • 51 citations

Intrathymic differentiation of cytotoxic T lymphocyte (CTL) precursors. I. The CTL immunocompetence of peanut agglutinin-positive (cortical) and negative (medullary) Lyt 123 thymocytes.

1980 • 50 citations

The separation of sub‐populations of T and B lymphocytes

1972 • 49 citations

Post‐Irradiation Thymocyte Regeneration After Bone Marrow Transplantation I. Regeneration and Quantification of Thymocyte Progenitor Cells In the Bone Marrow

1981 • 47 citations

Migration of Cells to the Thymus Demonstrated by Parabiosis.

1967 • 45 citations

Differentation of foetal mouse thymus. Ultrastructure of organ cultures and of subcapsular grafts.

1971 • 43 citations

Specific Helper T Cells Permit Differentiation of Thymic Anti-Self-Trinitrophenyl Cytotoxic Precursor Cells

1979 • 43 citations

Developmental and communicative interrelations of Ly123 and Ly1 cell sets.

1980 • 41 citations

Mitogenic effects of partially purified interleukin 2 on thymocyte subpopulations and spleen T cells of the mouse

1980 • 39 citations

Ly 9, an alloantigenic marker of lymphocyte differentiation.

1980 • 39 citations

Expression of Thymocyte Surface Alloantigens in the Fetal Mouse Thymus in vivo and in Organ Culture

1977 • 33 citations

Phenotypic and functional properties of murine thymocytes. II. Quantitation of host- and donor-derived cytolytic T lymphocyte precursors in regenerating radiation bone marrow chimeras.

1982 • 33 citations

A specific biosynthetic marker for immature thymic lymphoblasts. Active synthesis of thymus-leukemia antigen restricted to proliferating cells

1982 • 33 citations

Identification and characterization of immature thymocytes responsive to T cell growth factor

1981 • 31 citations

Immunohistochemical localization of host and donor-derived cells in the regenerating thymus of radiation bone marrow chimeras.

1984 • 31 citations

Hematopoietic thymocyte precursors: IV. Enrichment of the precursors and evidence for heterogeneity.

1978 • 30 citations

Acquisition of the T cell repertoire

1978 • 30 citations

Alloreactive and H-2-restricted Lyt 23 cytotoxic T lymphocytes derive from a common pool of antecedent Lyt 123 precursors.

1980 • 29 citations

The differentiation of T-lymphocytes

1976 • 29 citations

Loss of Thymus-Distinctive Serological Characteristics in Mice under Certain Conditions

1967 • 27 citations

Distribution of Lyt phenotypes in thymocyte subpopulations as measured by flow microfluorometry: selective enrichment of Lyt 1+23- thymocytes.

1980 • 27 citations

Functional and phenotypic properties of subpopulations of murine thymocytes.I. The bulk of peanut agglutinin‐positive Lyt‐1,2,3 thymocytes lacks precursors of cytotoxic T lymphocytes responsive to interleukin 2 (T cell growth factor)

1982 • 26 citations

Expression of differentiation antigens in subpopulations of mouse thymocytes: Regulation at the level of de novo synthesis

1980 • 26 citations

PHENOTYPIC CHARACTERIZATION OF EARLY EVENTS OF THYMUS REPOPULATION IN RADIATION BONE MARROW CHIMERAS

1983 • 25 citations

The size of functional T-lymphocyte pools within thymic medullary and cortical cell subsets.

1983 • 23 citations

Differentiation of thymus cells

1975 • 20 citations

Differences in the rejection of trunk skin and tail skin allografts involving weak histocompatibility loci.

1975 • 17 citations

DIFFERENCES IN THE REJECTION OF TRUNK SKIN AND TAIL SKIN ALLOGRAFTS INVOLVING WEAK HISTOCOMPATIBILITY LOCI

1975 • 17 citations

The ontogeny of thymic macrophages: Thymic macrophages express Ia from 15 days gestation onwards in the mouse

1984 • 16 citations

Identification of subsets of proliferating low Thy 1 cells in thymus cortex and medulla

1982 • 15 citations

Post‐Irradiation Thymocyte Regeneration After Bone Marrow Transplantation Ii. Physical Characteristics of Thymocyte Progenitor Cells

1981 • 14 citations

Selective expression of murine lymphocyte alloantigens controlled by the X-chromosome

1979 • 10 citations

Flow microfluorometric analysis of alloantigen expression during T cell development

1980 • 10 citations

Applications of light scatter to separation of stem cells.

1980 • 9 citations

Identification of TL⁺ thymocytes with different Lyt phenotypes

1979 • 7 citations

Differentiation of the thymus-leukemia (TL) antigen in the thymus of mouse embryos.

1968 • 6 citations

The Differentiation of T Lymphocytes

1978 • 5 citations

Separation of non-proliferating from proliferating thymic lymphocytes based on light scatter analysis

1979 • 5 citations

CELL POPULATION CHANGES IN REGENERATING THYMUS GRAFTS

1972 • 5 citations

A Re-Viewing of Thymocyte Differentiation

1984 • 4 citations