Strong TCR Ligation Without Costimulation Causes Rapid Onset of Fas-Dependent Apoptosis of Naive Murine CD4+ T Cells

The Fas Death Factor

1995 • 4,070 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis

1991 • 1,027 citations

Flow cytometric measurement of total DNA content and incorporated bromodeoxyuridine.

1983 • 978 citations

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1995 • 906 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cells.

1990 • 799 citations

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1994 • 747 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

Biochemical Mechanisms of IL-2–Regulated Fas-Mediated T Cell Apoptosis

1998 • 644 citations

B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes.

1988 • 537 citations

The Effects of Cyclosporin A on the Immune System

1985 • 442 citations

I-FLICE, a Novel Inhibitor of Tumor Necrosis Factor Receptor-1- and CD-95-induced Apoptosis

1997 • 372 citations

Inhibition of TNF-induced apoptosis by NF-κB

1998 • 370 citations

Requirement for the CD95 Receptor-Ligand Pathway in c-Myc-Induced Apoptosis

1997 • 370 citations

The Roles of Costimulation and Fas in T Cell Apoptosis and Peripheral Tolerance

1996 • 367 citations

Signal Transduction Pathways Regulated by Mitogen-activated/Extracellular Response Kinase Kinase Kinase Induce Cell Death

1996 • 346 citations

Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo.

1991 • 335 citations

Interleukin 4 (IL-4) or IL-7 Prevents the Death of Resting T Cells: Stat6 Is Probably Not Required for the Effect of IL-4

1997 • 293 citations

Costimulatory requirements of naive CD4+ T cells. ICAM-1 or B7-1 can costimulate naive CD4 T cell activation but both are required for optimum response.

1995 • 271 citations

CD28 costimulation prevents cell death during primary T cell activation.

1996 • 270 citations

The basis of autoimmunity: Part I mechanisms of aberrant self-recognition

1995 • 247 citations

IL-6 rescues resting mouse T cells from apoptosis.

1997 • 246 citations

T cell growth and differentiation induced by interleukin-HP1/IL-6, the murine hybridoma/plasmacytoma growth factor.

1988 • 244 citations

Resting Memory CD8+ T Cells are Hyperreactive to Antigenic Challenge In Vitro

1996 • 241 citations

Activation-induced apoptosis in lymphocytes

1994 • 238 citations

Negative Selection in the Thymus Includes Semimature T Cells

1997 • 224 citations

Intrathymic and extrathymic clonal deletion of T cells

1995 • 201 citations

CD28 costimulation inhibits TCR-induced apoptosis during a primary T cell response.

1996 • 198 citations

Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody.

1995 • 197 citations

Desensitization of Ras Activation by a Feedback Disassociation of the SOS-Grb2 Complex

1995 • 154 citations

CD28 and apoptosis

1995 • 147 citations

CD43 is a murine T cell costimulatory receptor that functions independently of CD28.

1995 • 137 citations

Fas (CD95) participates in peripheral T cell deletion and associated apoptosis in vivo

1995 • 134 citations

Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes

1998 • 130 citations

Upregulation of surface markers on dying thymocytes.

1995 • 122 citations

Fatal interactions: fas-induced apoptosis of mature T cells

1994 • 118 citations

TransfectedDrosophilacells as a probe for defining the minimal requirements for stimulating unprimed CD8⁺T cells

1996 • 117 citations

Regulation of apoptosis and T cell activation by Fas-specific mAb

1994 • 107 citations

Expression and functional properties of mouse B7/BB1 using a fusion protein between mouse CTLA4 and human gamma 1.

1993 • 95 citations

Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes.

1996 • 84 citations

Induction of unresponsiveness and impaired T cell expansion by staphylococcal enterotoxin B in CD28-deficient mice.

1996 • 78 citations

Stimulation of mature unprimed CD8+ T cells by semiprofessional antigen-presenting cells in vivo.

1992 • 70 citations

Cyclosporin A markedly enhances superantigen-induced peripheral T cell deletion and inhibits anergy induction.

1992 • 52 citations

Effect of Treatments with Cyclosporin A and Anti‐Interferon‐γ Antibodies on the Mechanisms of Immune Tolerance in Staphylococcal Enterotoxin B Primed Mice

1997 • 7 citations