A soluble transforming growth factor beta type III receptor suppresses tumorigenicity and metastasis of human breast cancer MDA-MB-231 cells.

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

Cancer statistics, 1998

1998 • 2,407 citations

Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor.

1992 • 1,217 citations

Betaglycan presents ligand to the TGFβ signaling receptor

1993 • 887 citations

The Transforming Growth Factor-βs

1991 • 882 citations

Expression cloning and characterization of the TGF-β type III receptor

1991 • 638 citations

TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice

1996 • 619 citations

Tumorigenicity and metastasis of human breast carcinoma cell lines in nude mice.

1990 • 617 citations

Enhanced expression of transforming growth factor β isoforms in pancreatic cancer correlates with decreased survival

1993 • 518 citations

Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate

1998 • 455 citations

Tumor suppressor activity of the TGF-β pathway in human cancers

1996 • 412 citations

Transforming growth factor beta stimulates mammary adenocarcinoma cell invasion and metastatic potential.

1990 • 398 citations

Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites

1994 • 379 citations

Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression.

1993 • 356 citations

Immunohistochemical staining for transforming growth factor beta 1 associates with disease progression in human breast cancer.

1992 • 346 citations

Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy.

1996 • 341 citations

Transforming growth factor β1 is associated with angiogenesis, metastasis, and poor clinical outcome in prostate cancer

1998 • 311 citations

Mammary tumor suppression by transforming growth factor beta 1 transgene expression.

1995 • 292 citations

High levels of transforming growth factor beta 1 in patients with colorectal cancer: Association with disease progression

1996 • 285 citations

A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer.

1998 • 274 citations

Transforming growth factor-beta 1 overproduction in prostate cancer: effects on growth in vivo and in vitro.

1992 • 242 citations

Tumor Formation Dependent on Proteoglycan Biosynthesis

1988 • 217 citations

Rapid, small-scale RNA isolation from tissue culture cells.

1991 • 216 citations

Immunocytochemical localization of secreted transforming growth factor-beta 1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinoma.

1993 • 208 citations

Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor beta receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthracene.

1997 • 195 citations

High levels of transforming growth factor beta 1 correlate with disease progression in human colon cancer.

1995 • 179 citations

Transforming growth factor β stimulates mamary adenocarcinoma cell invasion and metastasis potential

1990 • 164 citations

Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor beta 1.

1992 • 155 citations

Twenty-year follow-up of the breast cancers diagnosed during the Breast Cancer Detection Demonstration Project

1997 • 139 citations

Transforming growth factor beta 1 can induce estrogen-independent tumorigenicity of human breast cancer cells in athymic mice.

1993 • 138 citations

Growth stimulation of human breast cancer cells with anti-transforming growth factor beta antibodies: evidence for negative autocrine regulation by transforming growth factor beta.

1990 • 118 citations

Melanoma-associated expression of transforming growth factor-beta isoforms.

1996 • 107 citations

Localization of transforming growth factor-β isotypes in lesions of the human breast

1992 • 107 citations

Molecular cloning and characterization of the human and porcine transforming growth factor-β type III receptors

1992 • 85 citations

Blockade of Tumor Cell Transforming Growth Factor-βs Enhances Cell Cycle Progression and Sensitizes Human Breast Carcinoma Cells to Cytotoxic Chemotherapy

1998 • 84 citations

Transforming growth factor β and cancer

1995 • 73 citations

Expression of Transforming Growth Factor β Type III Receptor Suppresses Tumorigenicity of Human Breast Cancer MDA-MB-231 Cells

1997 • 69 citations

Expression of Transforming Growth Factor β (TGFβ) Type III Receptor Restores Autocrine TGFβ1 Activity in Human Breast Cancer MCF-7 Cells

1997 • 58 citations

Expression of transforming growth factor-beta 1 in human bladder cancer

1995 • 47 citations

Immunosuppressive cytokines (IL-10, TGF-β) genes expression in human gastric carcinoma tissues

1996 • 40 citations

The immunoregulatory roles of transforming growth factor beta.

1995 • 25 citations

Mutagenesis analysis of the membrane-proximal ligand binding site of the TGF-βreceptor type III extracellular domain

1995 • 22 citations

Drug resistance and gene amplification potential regulated by transforming growth factor beta 1 gene expression.

1995 • 13 citations