Deubiquitinating Enzymes: A New Class of Biological Regulators

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

UBIQUITIN-DEPENDENT PROTEIN DEGRADATION

1996 • 1,680 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

How Proteolysis Drives the Cell Cycle

1996 • 1,277 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

The Neuron-Specific Protein PGP 9.5 Is a Ubiquitin Carboxyl-Terminal Hydrolase

1989 • 864 citations

A 26 S protease subunit that binds ubiquitin conjugates.

1994 • 759 citations

Regulation of ubiquitin‐dependent processes by deubiquitinating enzymes

1997 • 576 citations

From Form to Function: Signaling by Protein Tyrosine Phosphatases

1996 • 526 citations

A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein

1997 • 484 citations

Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome

1997 • 451 citations

Regulation of Interferon-γ-Activated STAT1 by the Ubiquitin-Proteasome Pathway

1996 • 405 citations

Inactivation of the HR6B Ubiquitin-Conjugating DNA Repair Enzyme in Mice Causes Male Sterility Associated with Chromatin Modification

1996 • 402 citations

The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene

1993 • 379 citations

Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia

1997 • 359 citations

The cell-death machine

1996 • 351 citations

Form and Function in Protein Dephosphorylation

1996 • 334 citations

Proteasomes play an essential role in thymocyte apoptosis.

1996 • 316 citations

The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor.

1996 • 307 citations

Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T

1995 • 292 citations

Identification of p130^cas as a Substrate for the Cytosolic Protein Tyrosine Phosphatase PTP-PEST

1996 • 263 citations

Control of Cell Fate by a Deubiquitinating Enzyme Encoded by the fat facets Gene

1995 • 262 citations

Ubiquitin-specific proteases of Saccharomyces cerevisiae. Cloning of UBP2 and UBP3, and functional analysis of the UBP gene family

1992 • 250 citations

In vivo degradation of a transcriptional regulator: The yeast α2 repressor

1990 • 243 citations

In vivo disassembly of free polyubiquitin chains by yeast Ubp14 modulates rates of protein degradation by the proteasome

1997 • 235 citations

Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 Å resolution

1997 • 229 citations

A Deubiquitinating Enzyme Interacts with SIR4 and Regulates Silencing in S. cerevisiae

1996 • 228 citations

Activation-Induced Ubiquitination of the T Cell Antigen Receptor

1992 • 213 citations

A 25-kilodalton ubiquitin carrier protein (E2) catalyzes multi-ubiquitin chain synthesis via lysine 48 of ubiquitin.

1990 • 212 citations

Substrate Binding and Catalysis by Ubiquitin C-Terminal Hydrolases: Identification of Two Active Site Residues

1996 • 211 citations

Regulatory subunits of cAMP-dependent protein kinases are degraded after conjugation to ubiquitin: a molecular mechanism underlying long-term synaptic plasticity.

1993 • 208 citations

Ubiquitin carboxyl-terminal hydrolase acts on ubiquitin carboxyl-terminal amides.

1985 • 187 citations

The fat facets gene is required for Drosophila eye and embryo development

1992 • 187 citations

Ligand-induced polyubiquitination of the platelet-derived growth factor beta-receptor.

1992 • 173 citations

DUB-1, a deubiquitinating enzyme with growth-suppressing activity.

1996 • 170 citations

c-Cbl Is Transiently Tyrosine-phosphorylated, Ubiquitinated, and Membrane-targeted following CSF-1 Stimulation of Macrophages

1996 • 163 citations

A ubiquitin C-terminal isopeptidase that acts on polyubiquitin chains. Role in protein degradation.

1992 • 161 citations

Cloning and functional analysis of the ubiquitin-specific protease gene UBP1 of Saccharomyces cerevisiae

1991 • 161 citations

Comparisons of neuronal (PGP 9.5) and non-neuronal ubiquitin C-terminal hydrolases

1992 • 130 citations

Detection, resolution and nomenclature of multiple ubiquitin carboxyl-terminal esterases from bovine calf thymus

1989 • 129 citations

Ligand-dependent polyubiquitination of c-kit gene product: a possible mechanism of receptor down modulation in M07e cells

1994 • 119 citations

A novel transcriptional unit of the tre oncogene widely expressed in human cancer cells.

1992 • 117 citations

DUB-2 Is a Member of a Novel Family of Cytokine-inducible Deubiquitinating Enzymes

1997 • 111 citations

Growth Hormone-induced Signal Transduction Depends on an Intact Ubiquitin System

1997 • 69 citations

Molecular cloning and expression of a multiubiquitin chain binding subunit of the human 26S protease

1996 • 68 citations

The Unp proto-oncogene encodes a nuclear protein.

1994 • 66 citations

Kinetic studies of isopeptidase T: modulation of peptidase activity by ubiquitin

1995 • 65 citations

The MurineDUB-1Gene Is Specifically Induced by the βc Subunit of the Interleukin-3 Receptor

1996 • 54 citations

The Dose of a Putative Ubiquitin-Specific Protease Affects Position-Effect Variegation in Drosophila melanogaster

1996 • 51 citations

Molecular Cloning of a Novel Ubiquitin-specific Protease, UBP41, with Isopeptidase Activity in Chick Skeletal Muscle

1997 • 45 citations

Multiple Ubiquitin C-terminal Hydrolases from Chick Skeletal Muscle

1995 • 34 citations

Kinetic Studies on the Inhibition of Isopeptidase T by Ubiquitin Aldehyde

1996 • 32 citations

Cloning and Analysis of Expression of a Ubiquitin Carboxyl Terminal Hydrolase Expressed during Oogenesis in Drosophila melanogaster

1993 • 32 citations

Purification of a ubiquitin protein peptidase from yeast with efficient in vitro assays

1989 • 26 citations

Human TRE17 Oncogene Is Generated from a Family of Homologous Polymorphic Sequences by Single-Base Changes

1993 • 21 citations