A Comparative Study of the Expression of Cytotoxic Proteins in Allergic Contact Dermatitis and Psoriasis

Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity

1998 • 518 citations

T cell–mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis

2000 • 473 citations

T cell populations primed by hapten sensitization in contact sensitivity are distinguished by polarized patterns of cytokine production: interferon gamma-producing (Tc1) effector CD8+ T cells and interleukin (Il) 4/Il-10-producing (Th2) negative regulatory CD4+ T cells.

1996 • 398 citations

A family of serine esterases in lytic granules of cytolytic T lymphocytes

1987 • 393 citations

Perforin: structure and function

1995 • 361 citations

Major histocompatibility complex class I‐restricted CD8⁺ T cells and class II‐restricted CD4⁺ T cells, respectively, mediate and regulate contact sensitivity to dinitrofluorobenzene

1995 • 291 citations

Cytotoxicity Is Mandatory for CD8+ T Cell–mediated Contact Hypersensitivity

1999 • 258 citations

CD4+ Th1 and CD8+ Type 1 Cytotoxic T Cells Both Play a Crucial Role in the Full Development of Contact Hypersensitivity

2000 • 229 citations

Patients with Allergic Contact Dermatitis to Nickel and Nonallergic Individuals Display Different Nickel-Specific T Cell Responses. Evidence for the Presence of Effector CD8+ and Regulatory CD4+ T Cells

1998 • 192 citations

Infiltration of cytotoxic T cells in drug‐induced cutaneous eruptions

2000 • 185 citations

T‐cell‐mediated cytotoxicity against keratinocytes in sulfamethoxazol‐induced skin reaction

1998 • 145 citations

Perforin and serine esterase gene expression in stimulated human T cells. Kinetics, mitogen requirements, and effects of cyclosporin A.

1989 • 144 citations

Granule exocytosis, and not the Fas/Fas ligand system, is the main pathway of cytotoxicity mediated by alloantigen-specific CD4+ as well as CD8+ cytotoxic T lymphocytes in humans

2000 • 133 citations

A high proportion of T lymphocytes that infiltrate H-2-incompatible heart allografts in vivo express genes encoding cytotoxic cell-specific serine proteases, but do not express the MEL-14-defined lymph node homing receptor.

1988 • 130 citations

Human autoreactive CD4+ T cell clones use perforin- or Fas/Fas ligand-mediated pathways for target cell lysis.

1997 • 100 citations

The cell biology of CTL killing

1995 • 99 citations

Contact Hypersensitivity in MHC Class II-Deficient Mice Depends on CD8 T Lymphocytes Primed by Immunostimulating Langerhans Cells

1998 • 74 citations

Contact dermatitis I. Pathophysiology of contact sensitivity.

1999 • 74 citations

Target cell apoptosis induced by cytotoxic T cells and natural killer cells involves synergy between the pore‐forming protein, perforin, and the serine protease, granzyme B

1995 • 63 citations

MHC-Dependent and -Independent Activation of Human Nickel-Specific CD8+ Cytotoxic T Cells from Allergic Donors11This work was presented in part at the 26th Annual Meeting of the European Society of Dermatologic Research, Amsterdam, September 19–22, 1996

1998 • 59 citations

Cell-mediated cytotoxic mechanisms

1994 • 53 citations

Cytolytic effector mechanisms of human CD4+ cytotoxic T lymphocytes

1996 • 39 citations

Pathophysiology of Drug- Elicited Exanthems

2000 • 9 citations