Imiquimod is a strong inhibitor of tumor cell‐induced angiogenesis

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Cloning of a new cytokine that induces IFN-γ production by T cells

1995 • 2,584 citations

Inhibition of Angiogenesis In Vivo by Interleukin 12

1995 • 734 citations

Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein.

1996 • 635 citations

Interferon‐γ‐inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin‐12 for interferon‐γ production

1996 • 606 citations

Inhibition of angiogenesis by interferons: effects on tumor- and lymphocyte-induced vascular responses.

1987 • 491 citations

Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10

1996 • 480 citations

IFN-gamma-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones.

1996 • 425 citations

Angiogenesis and angiogenesis inhibition: An overview

1997 • 419 citations

Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis.

1998 • 419 citations

Review Article Imiquimod applied topically: a novel immune response modifier and new class of drug

1999 • 412 citations

Therapeutic response of basal cell carcinoma to the immune response modifier imiquimod 5% cream

1999 • 375 citations

Treatment of genital warts with an immune-response modifier (imiquimod)

1998 • 308 citations

Imiquimod, a Topical Immune Response Modifier, Induces Migration of Langerhans Cells11The authors have declared a conflict of interest.

2000 • 295 citations

Lymphocyte-induced angiogenesis: a quantitative and sensitive assay of the graft-vs.-host reaction.

1975 • 285 citations

Imiquimod 5% cream in the treatment of Bowen's disease

2001 • 269 citations

Cytokine induction by the immunomodulators imiquimod and S-27609

1995 • 268 citations

A Randomized, Controlled, Molecular Study of Condylomata Acuminata Clearance during Treatment with Imiquimod

1998 • 255 citations

The relationship between angiogenesis and the immune response in carcinogenesis and the progression of malignant disease

2000 • 199 citations

Imiquimod 5% cream for the treatment of superficial and nodular basal cell carcinoma: randomized studies comparing low-frequency dosing with and without occlusion

2002 • 192 citations

Inhibition of murine tumor growth by an interferon-inducing imidazoquinolinamine.

1992 • 174 citations

Biological implications of macrophage infiltration in human tumor angiogenesis

1999 • 160 citations

Modification of immunological responses and clinical disease during topical R-837 treatment of genital HSV-2 infection

1988 • 158 citations

In vivo antitumor effects of murine interferon- γ -inducing factor/interleukin-18 in mice bearing syngeneic Meth A sarcoma malignant ascites

1997 • 154 citations

Successful treatment of actinic keratosis with imiquimod cream 5%: a report of six cases

2001 • 138 citations

Cycle therapy of actinic keratoses of the face and scalp with 5% topical imiquimod cream: An open-label trial

2002 • 130 citations

Synergistic effect of retinoids and interferon α on tumor‐induced angiogenesis: Anti‐angiogenic effect on HPV‐harboring tumor‐cell lines

1994 • 123 citations

Imiquimod 5% cream (Aldara™)

1998 • 115 citations

Both E6 and E7 Oncoproteins of Human Papillomavirus 16 Inhibit IL-18-Induced IFN-γ Production in Human Peripheral Blood Mononuclear and NK Cells

2001 • 111 citations

Molecular foundations of cancer: New targets for intervention

1995 • 98 citations

Down modulation of IL‐18 expression by human papillomavirus type 16 E6 oncogene via binding to IL‐18

2001 • 96 citations

Effects of the immunomodulating agent R837 on acute and latent herpes simplex virus type 2 infections

1989 • 80 citations

Imiquimod: A cytokine inducer

2002 • 74 citations

Clinical effect of imiquimod 5% cream in the treatment of actinic keratosis

2002 • 72 citations

Retinoids, Interferon α, 1,25-dihydroxyvitamin D3 and their combination inhibit angiogenesis induced by non-HPV-harboring tumor cell lines. RARα mediates the antiangiogenic effect of retinoids

1995 • 71 citations

Bowen's Disease (Squamous Cell Carcinoma In Situ) in Immunosuppressed Patients Treated with Imiquimod 5% Cream and a COX Inhibitor, Sulindac: Potential Applications for This Combination of Immunotherapy

2001 • 69 citations

Interleukin-12 Inhibits Angiogenesis Induced by Human Tumor Cell Lines In Vivo

1996 • 67 citations

Autocrine growth limitation of human papillomavirus type 16-harboring keratinocytes by constitutively released tumor necrosis factor-alpha.

1992 • 63 citations

Self-administered topical imiquimod treatment of vulvar intraepithelial neoplasia. A report of four cases.

2000 • 57 citations

Imiquimod: a potential role in dermatology?

2002 • 46 citations

Successful treatment of anogenital Bowen's disease with the immunomodulator imiquimod, and monitoring of therapy by DNA image cytometry

2002 • 43 citations

Topical imiquimod treatment of superficial and nodular basal cell carcinomas in patients affected by basal cell nevus syndrome: a preliminary report

2002 • 39 citations

Imiquimod stimulates innate and cell mediated immunity which controls virus infections and tumors

2002 • 33 citations

Expression of the human papillomavirus type 16 genome in SK-v cells, a line derived from a vulvar intraepithelial neoplasia

1990 • 25 citations

Imiquimod

1999 • 19 citations

Imiquimod in the treatment of actinic keratoses and other intraepithelial neoplasms

2002 • 18 citations

[Recurrent Bowen's disease of the nail: treatment by topical imiquimod (Aldara)].

2003 • 18 citations