Opipramol, a potent sigma ligand, is an anti-ischemic agent: Neurochemical evidence for an interaction with the N-methyl-D-aspartate receptor complex in vivo by cerebellar cGMP measurements

Excitatory amino acids in the brain - focus on NMDA receptors

1987 • 641 citations

Cerebellar Dentate Nucleus

1977 • 571 citations

Uptake inhibition of biogenic amines by newer antidepressant drugs: Relevance to the dopamine hypothesis of depression

1977 • 264 citations

Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia.

1988 • 237 citations

N-methyl-D-aspartate-induced neuronal activation is selectively modulated by σ receptors

1990 • 225 citations

Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. II. Evidence for N-methyl-D-aspartate receptor antagonist properties.

1988 • 189 citations

Tricyclic antidepressants block N‐methyl‐D‐aspartate receptors: similarities to the action of zinc

1988 • 189 citations

Dextrorphan and levorphanol selectively block N-methyl-D-aspartate receptor-mediated neurotoxicity on cortical neurons.

1987 • 154 citations

Potential antipsychotic BMY 14802 selectively binds to sigma sites

1987 • 128 citations

Pharmacologically induced changes in the 3':5'-cyclic guanosine monophosphate content of rat cerebellar cortex: difference between apomorphine, haloperidol and harmaline.

1977 • 107 citations

In Vivo Modulation of the N‐Methyl‐D‐Aspartate Receptor Complex by D‐Serine: Potentiation of Ongoing Neuronal Activity as Evidenced by Increased Cerebellar Cyclic GMP

1989 • 100 citations

Dextromethorphan protects against cerebral infarction in a rat model of hypoxia-ischemia

1988 • 92 citations

Sigma receptors modulate both A9 and A10 dopaminergic neurons in the rat brain: functional interaction with NMDA receptors

1990 • 88 citations

Effects of dextromethorphan site ligands and allosteric modifiers on the binding of (+)-[3H]3-(-3-hydroxyphenyl)-N-(1-propyl)piperidine.

1989 • 82 citations

Tricyclic antidepressants and dextromethorphan bind with higher affinity to the phencyclidine receptor in the absence of magnesium and L-glutamate.

1989 • 72 citations

A review of the in vitro and in vivo neurochemical characterization of the NMDA/PCP/Glycine/Ion channel receptor macrocomplex

1990 • 70 citations

Sigma receptors modulate the hypothalamic-pituitary-adrenal (HPA) axis centrally: evidence for a functional interaction with NMDA receptors, in vivo

1990 • 67 citations

Ifenprodil and SL 82.0715 potently inhibit binding of [3H](+)-3-PPP to σ binding sites in rat brain

1990 • 60 citations

Mathematical analysis of concentration-response relationships. Method for the evaluation of the ED50 and the number of binding sites per receptor molecule using the logit transformation.

1977 • 60 citations

Antidepressants and metabolites that block GABAA receptors coupled to 35S-t-butylbicyclophosphorothionate binding sites in rat brain

1988 • 56 citations

Effects of antidepressant drugs on dopamine uptake and metabolism

1982 • 53 citations

Biological and methodological implications of prostaglandin involvement in mouse brain lipid peroxidation measurements

1989 • 52 citations

Tricyclic antidepressants block N‐methyl‐<scp>d</scp>‐aspartic acid‐induced lethality in mice

1989 • 35 citations

Blockade of hippocampal dopamine (da) receptors: A tool for antipsychotics with low extrapyramidal side effects

1988 • 30 citations

Neurochemical characterization of dopaminergic effects of opipramol, a potent sigma receptor ligand, in vivo

1990 • 24 citations

Ifenprodil and SL 82.0715 antagonize N-methyl-D-aspartate (NMDA)-coupled glycine receptor responses in vivo

1989 • 16 citations

In vivo antagonism of agonist actions at N-methyl-d-aspartate and N-methyl-d-aspartate-associated glycine receptors in mouse cerebellum: Studies of 1-hydroxy-3-aminopyrrolidone-2

1990 • 12 citations

Noradrenaline Antagonizes and Ouabain Potentiates the Effects of iV‐Methyl‐D‐Aspartate on Rat Cerebellar Cyclic GMP Production

1988 • 11 citations

The effect of antidepressants on L-5HTP-induced changes in rat plasma corticosteroids.

1980 • 9 citations

Inhibition of climbing and mossy fiber, and basket and stellate cell inputs to mouse cerebellar purkinje cells by novel anti-ischemic agents, ifenprodil and BMY-14802

1990 • 5 citations