Dextromethorphan and sigma ligands: Common sites but diverse effects

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

1976 • 2,883 citations

Psychotomimesis Mediated by κ Opiate Receptors

1986 • 822 citations

Pharmacology of opioids.

1983 • 627 citations

Neuro‐Psychopharmacology

1962 • 595 citations

Evidence for sigma opioid receptor: binding of [3H]SKF-10047 to etorphine-inaccessible sites in guinea-pig brain.

1982 • 409 citations

Autoradiographic localization of sigma receptor binding sites in guinea pig and rat central nervous system with (+)3H-3-(3-hydroxyphenyl)-N-(1- propyl)piperidine

1986 • 385 citations

Pharmacological and autoradiographic discrimination of sigma and phencyclidine receptor binding sites in brain with (+)-[3H]SKF 10,047, (+)-[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine and [3H]-1-[1-(2-thienyl)cyclohexyl]piperidine.

1986 • 339 citations

The human pharmacology and abuse potential of N-allylnoroxymorphone (naloxone).

1967 • 278 citations

Classification and nomenclature of phencyclidine and sigma receptor sites

1987 • 272 citations

Sigma and phencyclidine-like compounds as molecular probes in biology

1988 • 251 citations

3-PPP, a new centrally acting DA-receptor agonist with selectivity for autoreceptors

1981 • 229 citations

The analgesic effectiveness of nalorphine and nalorphine-morphine combinations in man.

1954 • 190 citations

Naltrexone fails to antagonize the σ effects of PCP and SKF 10,047 in the dog

1983 • 187 citations

Differential effects of dextrorphan and levorphanol on the excitation of rat spinal neurons by amino acids

1985 • 153 citations

Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a specific, competitive antagonist of sigma sites in brain

1986 • 152 citations

Demonstration of [3H]cyclazocine binding to multiple opiate receptor sites.

1981 • 151 citations

Dextrorphan and dextromethorphan, common antitussives, are antiepileptic and antagonize in brain slices

1988 • 137 citations

Structural determinants of sigma receptor affinity.

1987 • 124 citations

Subjective effects of narcotic antagonists cyclazocine and nalorphine on the Addiction Research Center Inventory (ARCI)

1970 • 124 citations

Phencyclidine and σ opiate receptors in brain: Biochemical and autoradiographical differentiation

1985 • 124 citations

Antagonism of the subjective, behavioral, pupillary, and respiratory depressant effects of cyclazocine by naloxone

1968 • 117 citations

Anticonvulsant effects of phencyclidine-like drugs: relation to N-methyl-d-aspartic acid antagonism

1988 • 99 citations

Dextromethorphan protects against cerebral infarction in a rat model of hypoxia-ischemia

1988 • 92 citations

The sigma receptor: a novel site implicated in psychosis and antipsychotic drug efficacy.

1988 • 83 citations

Effects of dextromethorphan site ligands and allosteric modifiers on the binding of (+)-[3H]3-(-3-hydroxyphenyl)-N-(1-propyl)piperidine.

1989 • 82 citations

The Sigma Receptor

1988 • 76 citations

Dextromethorphan and carbetapentane: centrally acting non-opioid antitussive agents with novel anticonvulsant properties

1986 • 74 citations

Demonstration of tolerance to and physical dependence of N-allylnormorphine (nalorphine).

1965 • 73 citations

High-affinity dextromethorphan binding sites in guinea pig brain. I. Initial characterization.

1983 • 71 citations

Psychotomimetic σ-opiates and PCP

1986 • 56 citations

Biochemical, behavioral, and electrophysiologic actions of the selective sigma receptor ligand (+)-pentazocine.

1988 • 55 citations

A very high affinity opioid binding site in rat brain: Demonstration by computer modeling

1984 • 54 citations

High affinity dextromethorphan binding sites in guinea pig brain: further characterization and allosteric interactions.

1988 • 49 citations

The Polymorphic Metabolism of Dextromethorphan

1987 • 48 citations

Characterization of specific binding sites for [3H](d)-N-allylnormetazocine in rat brain membranes.

1985 • 46 citations

Cyclazocine treatment of opiate dependence: A progress report

1971 • 43 citations

Dextromethorphan, a common antitussive, reduces kindled amygdala seizures in the rat

1988 • 41 citations

Psychotogenic drugs as models for schizophrenia *1Comments on ?the current status of the dopamine hypothesis of schizophrenia?

1988 • 37 citations

Caramiphen: a non-opioid antitussive with potent anticonvulsant properties in rats

1988 • 34 citations

Pharmacological specificity of some psychotomimetic and antipsychotic agents for the sigma and PCP binding sites

1988 • 30 citations

Analgesic and other effects of the d‐ and l‐isomers of pentazocine

1969 • 30 citations

STUDIES OF DRUGS GIVEN BEFORE ANAESTHESIA XIII: PENTAZOCINE AND OTHER OPIATE ANTAGONISTS

1967 • 26 citations

Studies of analgesic drugs. VII. Morphine antagonists as analgesics.

1961 • 24 citations

Allosteric modulation of dextromethorphan binding sites

1987 • 23 citations

Subjective effects of nalorphine in hospitalized patients.

1957 • 21 citations

[3H]PCP-3-OH and (+)[3H]SKF 10047 binding sites in rat brain membranes: evidence of multiplicity

1987 • 19 citations

Antitussive agents and their sites of action

1980 • 19 citations

SOME EFFECTS OF N–ALLYLNORMORPHINE ON NORMAL SUBJECTS AND A REVIEW OF THE LITERATURE

1955 • 15 citations

Autoradiographic localization of [³H]dextromethorphan in guinea pig brain: Allosteric enhancement by ropizine

1989 • 14 citations

High affinity binding of the antitussive dextromethorphan to guinea-pig brain

1980 • 12 citations

Quantitative conformational analyses predict distinct receptor sites for PCP-like and σ drugs

1987 • 12 citations

Twin Crossover Relative Potency Analgesic Assays in Man. II. Morphine Vs. 8‐Methoxycyclazocine

1977 • 7 citations