A single dose of passive immunotherapy has extended benefits on synapses and neurites in an Alzheimer's disease mouse model

The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

2002 • 13,092 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

2008 • 3,404 citations

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1999 • 3,112 citations

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

1992 • 2,520 citations

Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

2000 • 1,954 citations

Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

2000 • 1,498 citations

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

2008 • 948 citations

Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model

2002 • 858 citations

Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

2009 • 768 citations

Aβ Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the Proteasome

2004 • 760 citations

Early Aβ accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain

2004 • 617 citations

Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches

2004 • 548 citations

Dendritic Spine Abnormalities in Amyloid Precursor Protein Transgenic Mice Demonstrated by Gene Transfer and Intravital Multiphoton Microscopy

2005 • 544 citations

Imaging of amyloid-β deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy

2001 • 453 citations

Reversible Memory Loss in a Mouse Transgenic Model of Alzheimer's Disease

2002 • 423 citations

Imaging Aβ Plaques in Living Transgenic Mice with Multiphoton Microscopy and Methoxy-X04, a Systemically Administered Congo Red Derivative

2002 • 380 citations

Neuritic pathology and dementia in alzheimer's disease

1991 • 362 citations

Visual memory predicts Alzheimer’s disease more than a decade before diagnosis

2003 • 244 citations

Dendrite and dendritic spine alterations in alzheimer models

2004 • 243 citations

Plaque-induced neurite abnormalities: Implications for disruption of neural networks in Alzheimer’s disease

1999 • 228 citations

Cortical Synaptic IntegrationIn VivoIs Disrupted by Amyloid-β Plaques

2004 • 203 citations

Anti-Aβ antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice

2005 • 190 citations

Impaired Spine Stability Underlies Plaque-Related Spine Loss in an Alzheimer's Disease Mouse Model

2007 • 182 citations

Deglycosylated Anti-Amyloid-β Antibodies Eliminate Cognitive Deficits and Reduce Parenchymal Amyloid with Minimal Vascular Consequences in Aged Amyloid Precursor Protein Transgenic Mice

2006 • 151 citations

Amyloid-β Antibody Treatment Leads to Rapid Normalization of Plaque-Induced Neuritic Alterations

2003 • 150 citations

Intracerebroventricular amyloid-β antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice

2009 • 120 citations

Neuronal Structure is Altered by Amyloid Plaques

2004 • 111 citations

Imaging Amyloid-β Deposits In Vivo

2002 • 107 citations

Plaque-Derived Oxidative Stress Mediates Distorted Neurite Trajectories in the Alzheimer Mouse Model

2006 • 96 citations

Plaque-Induced Abnormalities in Neurite Geometry in Transgenic Models of Alzheimer Disease: Implications for Neural System Disruption

2001 • 94 citations

In Vivo Multiphoton Imaging of a Transgenic Mouse Model of Alzheimer Disease Reveals Marked Thioflavine-S-Associated Alterations in Neurite Trajectories

2003 • 89 citations

Amyloid proteins : methods and protocols

2005 • 82 citations

Aβ Associated Neuropil Changes

1998 • 77 citations

Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease

2008 • 66 citations

In Vivo Imaging of Amyloid-β Deposits in Mouse Brain With Multiphoton Microscopy

2005 • 46 citations