Lipid Products of Phosphoinositide 3-Kinase Interact with Rac1 GTPase and Stimulate GDP Dissociation

Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase

1991 • 1,779 citations

Signalling through the lipid products of phosphoinositide-3-OH kinase

1997 • 1,314 citations

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

1997 • 1,190 citations

A rapid and sensitive sub-micro phosphorus determination

1961 • 951 citations

Phosphoinositide 3-kinases: A conserved family of signal transducers

1997 • 944 citations

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

1989 • 933 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

1995 • 665 citations

Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase.

1996 • 560 citations

PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase

1995 • 542 citations

Rho Family GTPases Bind to Phosphoinositide Kinases

1995 • 469 citations

Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling.

1994 • 360 citations

A Role for Phosphoinositide 3-Kinase in Bacterial Invasion

1996 • 331 citations

Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins

1995 • 311 citations

Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin

1996 • 290 citations

Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways

1996 • 285 citations

Gelsolin is a downstream effector of rac for fibroblast motility

1998 • 267 citations

Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase.

1995 • 229 citations

Biologically active lipids are regulators of Rac.GDI complexation.

1993 • 206 citations

The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue

1997 • 192 citations

[1] Purification of recombinant Rho/Rac/G25K from Escherichia coli

1995 • 190 citations

Role of Protein-Phospholipid Interactions in the Activation of ARF1 by the Guanine Nucleotide Exchange Factor Arno

1997 • 169 citations

Regulation of GRP1-catalyzed ADP Ribosylation Factor Guanine Nucleotide Exchange by Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 151 citations

Identification and Cloning of Centaurin-α

1996 • 142 citations

Involvement of Phosphatidylinositide 3′-Kinase and Rac in Platelet-Derived Growth Factor-Induced Actin Reorganization and Chemotaxis

1997 • 120 citations

Effects of acid phospholipids on nucleotide exchange properties of ADP-ribosylation factor 1. Evidence for specific interaction with phosphatidylinositol 4,5-bisphosphate.

1994 • 104 citations

Phosphoinositide 3-kinase activation and platelet function

1996 • 103 citations

Tyrosine Phosphorylation and Relocation of SHIP Are Integrin-mediated in Thrombin-stimulated Human Blood Platelets

1997 • 99 citations

Regulation of AP-3 Function by Inositides

1997 • 99 citations

Phosphatidylinositol 4,5-bisphosphate Provides an Alternative to Guanine Nucleotide Exchange Factors by Stimulating the Dissociation of GDP from Cdc42Hs

1996 • 92 citations

Functional Interaction of ADP-ribosylation Factor 1 with Phosphatidylinositol 4,5-Bisphosphate

1997 • 91 citations

Activation and Translocation of Rho (and ADP Ribosylation Factor) by Insulin in Rat Adipocytes

1997 • 90 citations

Phosphoinositide 3-Kinase as an Upstream Regulator of the Small GTP-Binding Protein Rac in the Insulin Signaling of Membrane Ruffling

1995 • 78 citations

Mutational Analysis of Novel Effector Domains in Rac1 Involved in the Activation of Nicotinamide Adenine Dinucleotide Phosphate (Reduced) Oxidase

1998 • 60 citations

Intracellular Signalling: PI 3-kinase puts GTP on the Rac

1995 • 53 citations

Interaction between Cdc42Hs and RhoGDI Is Mediated through the Rho Insert Region

1997 • 46 citations

Selective Recognition of Phosphatidylinositol 3,4,5-Trisphosphate by a Synthetic Peptide

1997 • 40 citations

Down-regulation of G-protein-mediated Ca2+ sensitization in smooth muscle.

1997 • 33 citations

Phosphoinositide 3‐phosphatase segregates from phosphatidylinositol 3‐kinase in EGF‐stimulated A431 cells and fails to in vitro hydrolyse phosphatidylinositol(3,4,5)trisphosphate

1994 • 12 citations

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